中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2014年
4期
390-392
,共3页
刘秀荣%周艳茹%王建军%刘星%杨春伟%李俊娟%陈朔华%吴寿岭
劉秀榮%週豔茹%王建軍%劉星%楊春偉%李俊娟%陳朔華%吳壽嶺
류수영%주염여%왕건군%류성%양춘위%리준연%진삭화%오수령
糖尿病,2型%中心性肥胖%脑梗死%风险
糖尿病,2型%中心性肥胖%腦梗死%風險
당뇨병,2형%중심성비반%뇌경사%풍험
Diabetes mellitus,type 2%Central obesity%Cerebral infarction%Risk
目的 探讨中心性肥胖对2型糖尿病新发脑梗死事件的影响.方法 采用前瞻性队列研究方法,在2006-2007、2010-2011年开滦集团健康体检在职及离退休职工中,选择符合入选标准的8 306名2型糖尿病患者作为研究队列,依据基线WC水平分为中心性肥胖组和非肥胖组,应用多变量Cox比例风险回归模型分析中心性肥胖对2型糖尿病新发脑梗死事件的影响.平均随访38 ～ 53(48.05±3.09)个月.结果 (1)中心性肥胖组人群的平均年龄、BMI、SBP、DBP、脉压、FPG、TC、TG、LDL-C、UA水平均高于非肥胖组(P＜0.01).(2)中心性肥胖组脑梗死总累积发生率高于非肥胖组(3.1％VS.1.6％,P＜0.01);按性别分层后,男性中心性肥胖组仍高于非肥胖组(3.3％vs.1.7％,P＜0.01).(3)多变量Cox比例风险回归模型分析显示,校正其他危险因素后,中心性肥胖为2型糖尿病新发脑梗死事件的独立危险因素,RR=2.07(95％CI:1.39 ～ 3.09).结论 中心性肥胖增加2型糖尿病新发脑梗死事件的风险.
目的 探討中心性肥胖對2型糖尿病新髮腦梗死事件的影響.方法 採用前瞻性隊列研究方法,在2006-2007、2010-2011年開灤集糰健康體檢在職及離退休職工中,選擇符閤入選標準的8 306名2型糖尿病患者作為研究隊列,依據基線WC水平分為中心性肥胖組和非肥胖組,應用多變量Cox比例風險迴歸模型分析中心性肥胖對2型糖尿病新髮腦梗死事件的影響.平均隨訪38 ～ 53(48.05±3.09)箇月.結果 (1)中心性肥胖組人群的平均年齡、BMI、SBP、DBP、脈壓、FPG、TC、TG、LDL-C、UA水平均高于非肥胖組(P＜0.01).(2)中心性肥胖組腦梗死總纍積髮生率高于非肥胖組(3.1％VS.1.6％,P＜0.01);按性彆分層後,男性中心性肥胖組仍高于非肥胖組(3.3％vs.1.7％,P＜0.01).(3)多變量Cox比例風險迴歸模型分析顯示,校正其他危險因素後,中心性肥胖為2型糖尿病新髮腦梗死事件的獨立危險因素,RR=2.07(95％CI:1.39 ～ 3.09).結論 中心性肥胖增加2型糖尿病新髮腦梗死事件的風險.
목적 탐토중심성비반대2형당뇨병신발뇌경사사건적영향.방법 채용전첨성대렬연구방법,재2006-2007、2010-2011년개란집단건강체검재직급리퇴휴직공중,선택부합입선표준적8 306명2형당뇨병환자작위연구대렬,의거기선WC수평분위중심성비반조화비비반조,응용다변량Cox비례풍험회귀모형분석중심성비반대2형당뇨병신발뇌경사사건적영향.평균수방38 ～ 53(48.05±3.09)개월.결과 (1)중심성비반조인군적평균년령、BMI、SBP、DBP、맥압、FPG、TC、TG、LDL-C、UA수평균고우비비반조(P＜0.01).(2)중심성비반조뇌경사총루적발생솔고우비비반조(3.1％VS.1.6％,P＜0.01);안성별분층후,남성중심성비반조잉고우비비반조(3.3％vs.1.7％,P＜0.01).(3)다변량Cox비례풍험회귀모형분석현시,교정기타위험인소후,중심성비반위2형당뇨병신발뇌경사사건적독립위험인소,RR=2.07(95％CI:1.39 ～ 3.09).결론 중심성비반증가2형당뇨병신발뇌경사사건적풍험.
Objective To analyze the effect of central obesity on new-onset cerebral infarction events among type 2 diabetes mellitus patients in the Kailuan Group.Methods This was a prospective cohort study.In a total of 101 510 employees who had been carried out a healthy examination in Kailuan Group from Jul.2006 to Oct.2007.8 306 type 2 diabetes mellitus patients were selected.According to the baseline waist measurement,the observed population was divided into two groups—with central obesity or without.The total period of follow-up was 38-53 (48.05 ±3.09)months.Results 1) Mean age,BMI,the levels of SBP,DBP,pulse pressure,FPG,TC,LDL-C,uric acid significant increased in the central obesity group were higher than in the non-obese group (P＜0.01).2)The incidence of new onset cerebral infarction in obese group was higher than that in the non-obese group (3.1％ vs.1.6％,6.8％,P＜0.01 ; 3.3％ vs.1.7％,P＜0.01 in male respectively.3) Results from the multiple logistic regression analysis showed that,compared with the non-obese group,the obese group had an increase of relative risk (RR) on new onset cerebral infarction events after adjustment on age,gender and other risk factors,with RR value as 2.07 (95％CI:1.39-3.09,P＜0.01).Conclusion Type 2 diabetes mellitus patients with central obesity seemed to have increased the risk of new-onset cerebral infarction events.
