中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2014年
4期
397-400
,共4页
何玥%文师吾%谭红专%周书进%郭亚伟%王莎亚%沈琳%柳祎%胡丽
何玥%文師吾%譚紅專%週書進%郭亞偉%王莎亞%瀋琳%柳祎%鬍麗
하모%문사오%담홍전%주서진%곽아위%왕사아%침림%류의%호려
妊娠高血压综合征%低体重儿%巨大儿%交互作用
妊娠高血壓綜閤徵%低體重兒%巨大兒%交互作用
임신고혈압종합정%저체중인%거대인%교호작용
Pregnancy-induced hypertension%Low birth weight%Macrosomia%Interaction
目的 研究妊娠高血压综合征(妊高症)对低体重儿与巨大儿的影响及其与其他因素的交互作用.方法 应用回顾性队列研究方法,从湖南省浏阳市37个乡镇中随机抽取14个乡镇,收集2008年4月1日至2011年3月31日所有孕产妇孕期保健手册和分娩病历记录.内容包括基本信息、孕期血压和新生儿出生体重.多因素分析采用多项logistic回归分析.交互作用分析选择相加模型.结果 共获得有效数据6 102份.其中妊高症418例,发生率为6.9％;低体重儿166例(2.7％),巨大儿333例(5.5％).多因素研究显示妊高症、早产、孕前BMI＜ 18.5 kg/m2、孕期增重≥16 kg与新生儿体重的关联具有统计学意义.交互作用研究显示妊高症与早产对低体重儿存在较为明显的正交互作用[超额相对危险度(RERI) =35.08,交互作用归因比(API) =0.435,交互作用指数(S)=1.7],妊高症与孕前消瘦(孕前BMI＜ 18.5 kg/m2)对低体重儿存在正交互作用(RERI=1.426,API=0.291,S=1.575),妊高症与孕期体重增加对胎儿出生体重无明显的交互作用.结论 低体重儿和巨大儿的发生与妊高症、早产、孕前BMI、孕期体重的变化有关;且妊高症与早产及孕前BMI对新生儿体重的影响还存在明显的交互作用.
目的 研究妊娠高血壓綜閤徵(妊高癥)對低體重兒與巨大兒的影響及其與其他因素的交互作用.方法 應用迴顧性隊列研究方法,從湖南省瀏暘市37箇鄉鎮中隨機抽取14箇鄉鎮,收集2008年4月1日至2011年3月31日所有孕產婦孕期保健手冊和分娩病歷記錄.內容包括基本信息、孕期血壓和新生兒齣生體重.多因素分析採用多項logistic迴歸分析.交互作用分析選擇相加模型.結果 共穫得有效數據6 102份.其中妊高癥418例,髮生率為6.9％;低體重兒166例(2.7％),巨大兒333例(5.5％).多因素研究顯示妊高癥、早產、孕前BMI＜ 18.5 kg/m2、孕期增重≥16 kg與新生兒體重的關聯具有統計學意義.交互作用研究顯示妊高癥與早產對低體重兒存在較為明顯的正交互作用[超額相對危險度(RERI) =35.08,交互作用歸因比(API) =0.435,交互作用指數(S)=1.7],妊高癥與孕前消瘦(孕前BMI＜ 18.5 kg/m2)對低體重兒存在正交互作用(RERI=1.426,API=0.291,S=1.575),妊高癥與孕期體重增加對胎兒齣生體重無明顯的交互作用.結論 低體重兒和巨大兒的髮生與妊高癥、早產、孕前BMI、孕期體重的變化有關;且妊高癥與早產及孕前BMI對新生兒體重的影響還存在明顯的交互作用.
목적 연구임신고혈압종합정(임고증)대저체중인여거대인적영향급기여기타인소적교호작용.방법 응용회고성대렬연구방법,종호남성류양시37개향진중수궤추취14개향진,수집2008년4월1일지2011년3월31일소유잉산부잉기보건수책화분면병력기록.내용포괄기본신식、잉기혈압화신생인출생체중.다인소분석채용다항logistic회귀분석.교호작용분석선택상가모형.결과 공획득유효수거6 102빈.기중임고증418례,발생솔위6.9％;저체중인166례(2.7％),거대인333례(5.5％).다인소연구현시임고증、조산、잉전BMI＜ 18.5 kg/m2、잉기증중≥16 kg여신생인체중적관련구유통계학의의.교호작용연구현시임고증여조산대저체중인존재교위명현적정교호작용[초액상대위험도(RERI) =35.08,교호작용귀인비(API) =0.435,교호작용지수(S)=1.7],임고증여잉전소수(잉전BMI＜ 18.5 kg/m2)대저체중인존재정교호작용(RERI=1.426,API=0.291,S=1.575),임고증여잉기체중증가대태인출생체중무명현적교호작용.결론 저체중인화거대인적발생여임고증、조산、잉전BMI、잉기체중적변화유관;차임고증여조산급잉전BMI대신생인체중적영향환존재명현적교호작용.
Objective To research the influence of pregnancy-induced hypertension (PIH) on neonatal birth weight and its interaction with other factors.Methods A retrospective cohort study was conducted in this study.14 townships were randomly selected by cluster random sampling method from 37 townships in Liuyang city,Hunan province.All pregnant women from these 14 townships with pregnancy care manual and delivery record,during April 1st,2008 to March 31st,2011 were selected as subjects of this study.Blood pressure during pregnancy and neonatal birth weight were recorded.Multinomial logistic regression model was used to adjust the confounding factors.Addictive effects model was used for interaction analysis.Results Data from 6 102 subjects were collected,including 418 (6.9％) pregnant women with PIH,166 (2.7％) infants with low birth weight and 333(5.5％)with fetal macrosomia.Results from the Multinomial logistic regression analysis showed significant association between neonatal birth weight and PIH,premature birth,BMI ＜ 18.5before pregnancy,and weight gain ≥ 16 kg during pregnancy.Data from the Interaction analysis showed that there was strong positive interactions between PIH and premature birth to low birth weight infants (RERI=35.08,API=0.435,S=1.7),and between PIH and BMI＜18.5 before pregnancy to low birth weight infants.However,no significant interaction was found between PIH and weight gain.Conclusion Factors as PIH,premature birth,BMI before pregnancy and weight gain showed impact on low birth weight or fetal macrosomia.PIH also showed significant interaction on neonatal birth weight with premature birth as well as BMI before pregnancy,respectively.
