CAJ | 학술논문

目的探讨青年高血压患者静息心率与颈动脉结构的关系.方法选择2009年1月至2012年1月新疆医科大学第一附属医院高血压科663例年龄在18～45(38.01±5.78)岁的青年原发性高血压住院患者.按每分钟静息心率水平分为3组:A组(＜70次,n=163),B组(70次≤心率＜80次,n=268),C组(≥80次,n=232).超声检查双侧颈动脉内膜中层厚度和动脉内径,观察颈动脉血管壁斑块发生情况;对比各组颈动脉结构相关参数,进行方差分析和双变量相关分析.结果 (1)3组患者入院时SBP、DBP总体差异均有统计学意义(P＜0.01),A组DBP高于B组(P＜0.05),C组SBP和DBP高于B组(P＜0.01);(2)3组患者颈动脉结构比较,右侧颈动脉内径A组高于C组(P＜0.05),左侧颈动脉内径A组高于B组(P＜0.05),左侧颈动脉内径A组高于C组(P＜0.05);(3)静息心率与入院SBP、DBP在0.01水平(双侧)上显著正相关(r值分别为0.112、0.118),而与左颈动脉内径在0.05水平(双侧)上显著负相关(r=-0.89),与右侧颈动脉内径呈负相关,但相关性不甚密切(r=-0.075,P=0.068).结论青年高血压患者静息心率增快可出现血压增高、颈动脉内径减少的趋势.
목적 탐토청년고혈압환자정식심솔여경동맥결구적관계.방법 선택2009년1월지2012년1월신강의과대학제일부속의원고혈압과663례년령재18～45(38.01±5.78)세적청년원발성고혈압주원환자.안매분종정식심솔수평분위3조:A조(＜70차,n=163),B조(70차≤심솔＜80차,n=268),C조(≥80차,n=232).초성검사쌍측경동맥내막중층후도화동맥내경,관찰경동맥혈관벽반괴발생정황;대비각조경동맥결구상관삼수,진행방차분석화쌍변량상관분석.결과 (1)3조환자입원시SBP、DBP총체차이균유통계학의의(P＜0.01),A조DBP고우B조(P＜0.05),C조SBP화DBP고우B조(P＜0.01);(2)3조환자경동맥결구비교,우측경동맥내경A조고우C조(P＜0.05),좌측경동맥내경A조고우B조(P＜0.05),좌측경동맥내경A조고우C조(P＜0.05);(3)정식심솔여입원SBP、DBP재0.01수평(쌍측)상현저정상관(r치분별위0.112、0.118),이여좌경동맥내경재0.05수평(쌍측)상현저부상관(r=-0.89),여우측경동맥내경정부상관,단상관성불심밀절(r=-0.075,P=0.068).결론 청년고혈압환자정식심솔증쾌가출현혈압증고、경동맥내경감소적추세.
Objective To investigate the relationship between resting heart rate (RHR)and carotid artery structure in young hypertensive patients.Methods A total of 663 primary hypertensive patients aged between 18 and 45 (38.01 ± 5.78) were chosen from the First Affiliated Hospital of Xinjiang Medical University from January,2009 to January,2012.Patients under this study were divided into three groups according to their RHRs:group A (RHR＜70 bpm,n=163),group B(70 bpm≤RHR＜80 bpm,n=268),group C (RHR≥80 bpm,n=232).Data on bilateral carotid artery intima-media thickness,common carotid artery diameter were detected by carotid ultra-sonography.Indexes of carotid artery were analyzed by both variance and bi-variate correlation analysis.Results 1)Differences in the blood pressure among three groups showed statistical significance (P＜0.01),with diastolic pressure in group A higher than in group B (P＜0.05),while both systolic and diastolic pressure in group C higher than in group B (P＜0.01).2)In group A,the right carotid artery diameter was higher than in group C(P＜0.05) and the left carotid artery diameter higher than in group B(P＜ 0.05) with the left carotid artery diameter higher than in group C (P＜0.05).3) Significant positive correlations were found between RHR and blood pressure (r =0.112,0.118) and negative correlation between RHR and left carotid artery diameter (r=-0.89).However,correlation between RHR and right carotid artery diameter was not significant (r=-0.075,P=0.068).Conclusion When blood pressure had an increase,we found that the carotid artery diameter was decreasing along with the increasing RHR among the young hypertensive patients.