CAJ | 학술논문

目的探讨生命早期经历饥荒对成年后患糖尿病(DM)及IFG检出率的影响.方法在参加2006-2007年度开滦集团健康体检的101 510名职工中,选取1956-10-01至1964-09-30期间在河北省出生并排除研究资料缺失者,最终纳入统计分析为19 347人.依据出生日期将1959-10-01至1961-09-30出生的研究对象作为饥荒暴露组,1958-10-01至1959-09-30和1961-10-01至1962-09-30的研究对象作为饥荒半暴露组,1956-10-01至1958-09-30和1962-10-01至1964-09-30的研究对象作为对照组,比较三组DM患病率、IFG检出率,并采用logistic回归模型分析生命早期经历饥荒对两者的影响.结果饥荒暴露组DM患病率、IFG检出率分别为8.99％、8.96％,饥荒半暴露组分别为8.05％、9.35％,对照组分别为7.71％、8.20％.多因素logistic回归分析显示生命早期经历饥荒增加了成年后DM患病风险和IFG检出风险,OR值分别为1.218(95％CI:1.056 ～ 1.404,P=0.007)、1.142(95％CI:0.994～1.312,P=0.061).性别分层后,男性人群OR直分别为1.163(95％CI:1.001 ～ 1.350,P=0.048)、1.213(95％CI:1.039～1.417,P=0.015);女性人群OR值分别为1.319(95％CI:0.920～1.891,P=0.132)、0.990 (95％CI:0.679～ 1.444,P=0.959).结论生命早期经历饥荒增加了成年后DM患病、IFG检出风险,并主要表现在男性人群中.
목적 탐토생명조기경력기황대성년후환당뇨병(DM)급IFG검출솔적영향.방법 재삼가2006-2007년도개란집단건강체검적101 510명직공중,선취1956-10-01지1964-09-30기간재하북성출생병배제연구자료결실자,최종납입통계분석위19 347인.의거출생일기장1959-10-01지1961-09-30출생적연구대상작위기황폭로조,1958-10-01지1959-09-30화1961-10-01지1962-09-30적연구대상작위기황반폭로조,1956-10-01지1958-09-30화1962-10-01지1964-09-30적연구대상작위대조조,비교삼조DM환병솔、IFG검출솔,병채용logistic회귀모형분석생명조기경력기황대량자적영향.결과 기황폭로조DM환병솔、IFG검출솔분별위8.99％、8.96％,기황반폭로조분별위8.05％、9.35％,대조조분별위7.71％、8.20％.다인소logistic회귀분석현시생명조기경력기황증가료성년후DM환병풍험화IFG검출풍험,OR치분별위1.218(95％CI:1.056 ～ 1.404,P=0.007)、1.142(95％CI:0.994～1.312,P=0.061).성별분층후,남성인군OR직분별위1.163(95％CI:1.001 ～ 1.350,P=0.048)、1.213(95％CI:1.039～1.417,P=0.015);녀성인군OR치분별위1.319(95％CI:0.920～1.891,P=0.132)、0.990 (95％CI:0.679～ 1.444,P=0.959).결론 생명조기경력기황증가료성년후DM환병、IFG검출풍험,병주요표현재남성인군중.
Objective To investigate the effects of famine-experience during early life on diabetes mellitus and impaired fasting glucose in the adulthood.Methods In a total of 101 510 employees who took part in the health examination at the Kailuan Group between 2006 to 2007 were recruited.All the study subjects were born in Hebei province between 1956-10-01 and 1964-09-30 but those who had incomplete data were excluded.19 347 subjects were finally included for analysis.Members from the famine-exposed group were born between Oct.1,1959 and Sep.30,1961.There was a semi-exposed group with members born between Oct.1,1958 and Sept.30,1959 and from Oct.1,1961 to Sept.30,1962 but members from the control group were born from Oct.1,1956 to Sept.30,1958 and from Oct.1,1962 to Sept.30,1964.Prevalence rates on diabetes mellitus and the detection rate of impaired fasting glucose among the three groups were compared.Logistic regression model was used to analyze the effects of famine-experience during early life with the prevalence of diabetes mellitus and the detection rate of impaired fasting glucose during adulthood.Results Prevalence of diabetes mellitus and the detection rate of impaired fasting glucose in the famine-exposed adult-cohort groups were 8.99％,8.96％ while 8.05％ and 9.35％ in the semi-exposure groups,7.71％ and 8.20％ in the control group.Results from the multivariate logistic regression analysis showed that experiences of famine during early life increased the risk of diabetes mellitus and impaired fasting glucose in adulthood with the odds ratios as 1.218 (95％ CI:1.056-1.404,P=0.007) and 1.142 (95％ CI:0.994-1.312,P=0.061).After stratification by sex,odds ratios in males were 1.163 (95％ C I:1.001-1.350,P=0.048) and 1.213 (95％ CI:1.039-1.417,P=0.015).The odds ratios in females were 1.319 (95％ CI:0.920-1.891,P=0.132) and 0.990 (95％ CI:0.679-1.444,P=0.959).Conclusion Experiences of famine during early life increased the risk of diabetes mellitus and impaired fasting glucose in the adulthood.However,this negative effect existed mainly in the males,according to the results from our study.