中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2014年
9期
1058-1061
,共4页
王林%帅平%刘玉萍%程幼夫%杨华%李婷欣%龚立荣%任姣姣%王洪佳
王林%帥平%劉玉萍%程幼伕%楊華%李婷訢%龔立榮%任姣姣%王洪佳
왕림%수평%류옥평%정유부%양화%리정흔%공립영%임교교%왕홍가
血脂异常%脉搏波传导速度%脂蛋白比值%血压正常高值%动脉僵硬度
血脂異常%脈搏波傳導速度%脂蛋白比值%血壓正常高值%動脈僵硬度
혈지이상%맥박파전도속도%지단백비치%혈압정상고치%동맥강경도
[Key words] Abnormal blood lipid%Pulse wave velocity%Lipoprotein ration%Prehypertension%Arterial stiffness
目的 探讨血脂和脂蛋白比值对血压正常高值人群脉搏波传导速度的影响.方法 选择11 611名血压正常的健康体检者,分为正常血压值组(血压＜ 120/80 mmHg)和血压正常高值组(血压为120 ～ 139/80 ～ 89 mmHg).应用全自动动脉硬化仪测定人选者肱踝脉搏波传导速度(baPWV),同时测量身高、体重、FPG、TC、TG、HDL-C、LDL-C等指标,并计算HDL-C和TC/HDL-C比值、LDL-C/HDL-C比值.分析血脂和脂蛋白比值异常情况对不同血压组脉搏波传导速度的影响.结果 血压正常高值组的baPWV异常率均高于血压正常组.血压正常组中除HDL-C外,TC、TG、LDL-C、TC/HDL-C、LDL-C/HDL-C的升高均使baPWV的异常率显著增加(P＜0.001).血压正常高值组中,TC和LDL-C的升高使baPWV的异常率显著增加(P＜0.001).多元logistic回归分析显示,除年龄、BMI、FPG外,TC/HDL-C异常是血压正常组动脉僵硬度增高的独立危险因子(OR=1.732),TG异常是血压正常高值组的独立危险因素(OR=1.301).结论 在正常血压不同水平下,血脂和脂蛋白比值的异常是动脉僵硬度增高的独立危险因素.
目的 探討血脂和脂蛋白比值對血壓正常高值人群脈搏波傳導速度的影響.方法 選擇11 611名血壓正常的健康體檢者,分為正常血壓值組(血壓＜ 120/80 mmHg)和血壓正常高值組(血壓為120 ～ 139/80 ～ 89 mmHg).應用全自動動脈硬化儀測定人選者肱踝脈搏波傳導速度(baPWV),同時測量身高、體重、FPG、TC、TG、HDL-C、LDL-C等指標,併計算HDL-C和TC/HDL-C比值、LDL-C/HDL-C比值.分析血脂和脂蛋白比值異常情況對不同血壓組脈搏波傳導速度的影響.結果 血壓正常高值組的baPWV異常率均高于血壓正常組.血壓正常組中除HDL-C外,TC、TG、LDL-C、TC/HDL-C、LDL-C/HDL-C的升高均使baPWV的異常率顯著增加(P＜0.001).血壓正常高值組中,TC和LDL-C的升高使baPWV的異常率顯著增加(P＜0.001).多元logistic迴歸分析顯示,除年齡、BMI、FPG外,TC/HDL-C異常是血壓正常組動脈僵硬度增高的獨立危險因子(OR=1.732),TG異常是血壓正常高值組的獨立危險因素(OR=1.301).結論 在正常血壓不同水平下,血脂和脂蛋白比值的異常是動脈僵硬度增高的獨立危險因素.
목적 탐토혈지화지단백비치대혈압정상고치인군맥박파전도속도적영향.방법 선택11 611명혈압정상적건강체검자,분위정상혈압치조(혈압＜ 120/80 mmHg)화혈압정상고치조(혈압위120 ～ 139/80 ～ 89 mmHg).응용전자동동맥경화의측정인선자굉과맥박파전도속도(baPWV),동시측량신고、체중、FPG、TC、TG、HDL-C、LDL-C등지표,병계산HDL-C화TC/HDL-C비치、LDL-C/HDL-C비치.분석혈지화지단백비치이상정황대불동혈압조맥박파전도속도적영향.결과 혈압정상고치조적baPWV이상솔균고우혈압정상조.혈압정상조중제HDL-C외,TC、TG、LDL-C、TC/HDL-C、LDL-C/HDL-C적승고균사baPWV적이상솔현저증가(P＜0.001).혈압정상고치조중,TC화LDL-C적승고사baPWV적이상솔현저증가(P＜0.001).다원logistic회귀분석현시,제년령、BMI、FPG외,TC/HDL-C이상시혈압정상조동맥강경도증고적독립위험인자(OR=1.732),TG이상시혈압정상고치조적독립위험인소(OR=1.301).결론 재정상혈압불동수평하,혈지화지단백비치적이상시동맥강경도증고적독립위험인소.
Objective To explore the effect of blood lipid and lipoprotein ratios on the change of brachial-ankle pulse wave velocity (baPWV) among prehypertensive subjects.Methods 11 611 subjects with normal blood pressure (BP) were divided into two groups,which was one with optimal blood pressure (B P ＜ 120/80 mmHg) and the other with prehypertension (BP:120-139/80-89 mmHg).Height,weight,baPWV,fasting blood-glucose,TC,TG,LDL-C and HDL-C were detected.Results The abnormal rate ofbaPWV in prehypertension group was obviously higher than that in the optimal blood pressure group.For optimal blood pressure group,the abnormality of TG,TC,LDL-C,TC/HDL-C as well as LDL-C/HDL-C,caused the increase of baPWV significantly (P＜0.001).For prehypertensive group,the abnormality of TC and LDL-C caused the significant increase of baPWV (P＜0.001).Results from logistic regression analysis showed that except for age,BMI and fasting blood-glucose,TC/HDL-C increasing was the independent risk factor in optimal blood pressure group,while TG increasing was for the prehypertension group.Conclusion With different normal BP level,both abnormality of blood lipid and lipoprotein ratio were the independent risk factors for baPWV increasing.
