中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2012年
2期
123-126
,共4页
陈鑫%李宇峰%王萍%岳东民%叶青%杨卓%臧伟清%王广浩%曲晓光%高福金
陳鑫%李宇峰%王萍%嶽東民%葉青%楊卓%臧偉清%王廣浩%麯曉光%高福金
진흠%리우봉%왕평%악동민%협청%양탁%장위청%왕엄호%곡효광%고복금
前列腺特异抗原%前列腺液%前列腺肿瘤%细胞诊断学%白细胞
前列腺特異抗原%前列腺液%前列腺腫瘤%細胞診斷學%白細胞
전렬선특이항원%전렬선액%전렬선종류%세포진단학%백세포
Prostate-specific antigen%Prostatic fluid%Prostatic neoplasms%Cytodiagnosis%Leukocytes
目的 研究PSA值增高患者前列腺液脱落细胞学检查诊断前列腺癌的临床分析及前列腺液中白细胞状态对血清PSA的影响.方法 130例PSA值增高患者在行经直肠前列腺穿刺活检前,行直肠指检按摩获取前列腺液,进行瑞氏染色和脱落细胞学分级,并行前列腺液中的白细胞计数.方差分析PSA水平在不同脱落细胞学分级之间的差异,采用Spearman相关分析检验前列腺液体积、白细胞密度和白细胞总数与患者的tPSA、fPSA、年龄、前列腺体积的相关性,行t检验或Wilcoxon 秩和检验比较前列腺癌和非前列腺癌组tPSA、fPSA、年龄、前列腺液体积、前列腺液中的白细胞密度、白细胞总数、前列腺体积的差异. 结果 病理学结果显示前列腺癌77例(59.2％),非前列腺癌53例(40.8％).脱落细胞分级Ⅰ ～Ⅴ级分别为28例(21.5％),32例(24.6％),22例(16.9％),36例(27.7％),12例(9.2％).脱落细胞学检查特异性为100％.在PSA≥20 μg/L的患者中,具有较高的敏感性(10/16,62.5％).在脱落细胞学分级Ⅰ～Ⅳ级之间PSA值差异无统计学意义(P＞0.05),Ⅰ～Ⅳ级与Ⅴ级之间PSA值比较差异有统计学意义(P＜0.05).前列腺液体积和白细胞总数与前列腺体积呈显著性相关,非前列腺癌患者的前列腺体积、白细胞密度和总数显著高于前列腺癌患者,且其血清PSA值与前列腺液中的白细胞密度呈正相关性. 结论 PSA值增高患者行前列腺液脱落细胞学检查诊断前列腺癌是一种有效的方法,尤其在患者PSA值较高时.非前列腺癌患者的PSA值增高可能与前列腺液中的白细胞增高有关.
目的 研究PSA值增高患者前列腺液脫落細胞學檢查診斷前列腺癌的臨床分析及前列腺液中白細胞狀態對血清PSA的影響.方法 130例PSA值增高患者在行經直腸前列腺穿刺活檢前,行直腸指檢按摩穫取前列腺液,進行瑞氏染色和脫落細胞學分級,併行前列腺液中的白細胞計數.方差分析PSA水平在不同脫落細胞學分級之間的差異,採用Spearman相關分析檢驗前列腺液體積、白細胞密度和白細胞總數與患者的tPSA、fPSA、年齡、前列腺體積的相關性,行t檢驗或Wilcoxon 秩和檢驗比較前列腺癌和非前列腺癌組tPSA、fPSA、年齡、前列腺液體積、前列腺液中的白細胞密度、白細胞總數、前列腺體積的差異. 結果 病理學結果顯示前列腺癌77例(59.2％),非前列腺癌53例(40.8％).脫落細胞分級Ⅰ ～Ⅴ級分彆為28例(21.5％),32例(24.6％),22例(16.9％),36例(27.7％),12例(9.2％).脫落細胞學檢查特異性為100％.在PSA≥20 μg/L的患者中,具有較高的敏感性(10/16,62.5％).在脫落細胞學分級Ⅰ～Ⅳ級之間PSA值差異無統計學意義(P＞0.05),Ⅰ～Ⅳ級與Ⅴ級之間PSA值比較差異有統計學意義(P＜0.05).前列腺液體積和白細胞總數與前列腺體積呈顯著性相關,非前列腺癌患者的前列腺體積、白細胞密度和總數顯著高于前列腺癌患者,且其血清PSA值與前列腺液中的白細胞密度呈正相關性. 結論 PSA值增高患者行前列腺液脫落細胞學檢查診斷前列腺癌是一種有效的方法,尤其在患者PSA值較高時.非前列腺癌患者的PSA值增高可能與前列腺液中的白細胞增高有關.
목적 연구PSA치증고환자전렬선액탈락세포학검사진단전렬선암적림상분석급전렬선액중백세포상태대혈청PSA적영향.방법 130례PSA치증고환자재행경직장전렬선천자활검전,행직장지검안마획취전렬선액,진행서씨염색화탈락세포학분급,병행전렬선액중적백세포계수.방차분석PSA수평재불동탈락세포학분급지간적차이,채용Spearman상관분석검험전렬선액체적、백세포밀도화백세포총수여환자적tPSA、fPSA、년령、전렬선체적적상관성,행t검험혹Wilcoxon 질화검험비교전렬선암화비전렬선암조tPSA、fPSA、년령、전렬선액체적、전렬선액중적백세포밀도、백세포총수、전렬선체적적차이. 결과 병이학결과현시전렬선암77례(59.2％),비전렬선암53례(40.8％).탈락세포분급Ⅰ ～Ⅴ급분별위28례(21.5％),32례(24.6％),22례(16.9％),36례(27.7％),12례(9.2％).탈락세포학검사특이성위100％.재PSA≥20 μg/L적환자중,구유교고적민감성(10/16,62.5％).재탈락세포학분급Ⅰ～Ⅳ급지간PSA치차이무통계학의의(P＞0.05),Ⅰ～Ⅳ급여Ⅴ급지간PSA치비교차이유통계학의의(P＜0.05).전렬선액체적화백세포총수여전렬선체적정현저성상관,비전렬선암환자적전렬선체적、백세포밀도화총수현저고우전렬선암환자,차기혈청PSA치여전렬선액중적백세포밀도정정상관성. 결론 PSA치증고환자행전렬선액탈락세포학검사진단전렬선암시일충유효적방법,우기재환자PSA치교고시.비전렬선암환자적PSA치증고가능여전렬선액중적백세포증고유관.
Objective To study the value of the exfoliative cytology of prostatic fluid obtained from patients with elevated PSA in prostate cancer diagnosis. Methods Prostatic fluid was obtained from 130 patients with elevated PSA before prostate biopsy and then the Wright's stain and cytological class were done.Each cytological class and patient's age,PSA,total prostate volume,prostatic fluid volume and the number of leukocyte in the prostatic fluid were recorded.The relationship of leukocyte number and patient's age,PSA and prostate volume was analyzed by Spearman correlation test. Results Prostate biopsy pathology results showed that there were 77 (59.2％) cancer cases and 53 (40.8％) non-cancer cases.Patient numbers in cytological class 1 to 5 were 28 (21.5％),32 (24.6％),22 (16.9％),36 (27.7％),12(9.2％),respectively.The prostate fluid cytology had a specificity of 100％ and high sensitivity of 62.5％(10/16) in patients with PSA≥20 μg/L.PSA value had significant difference between class 1,2,3,4and 5.Significant correlation was found among the prostatic fluid volume,total leukocyte number and prostate volume.Prostate volume,leukycyte density and total leukycyte number was significant higher in noncancer patients than in prostate cancer patients. Conclusions The exfoliative cytology of prostatic fluid is a valuable method in detecting prostate cancer,particularly in patients with high PSA levels.It has the advantages of non-invasion and less injury than prostate biopsy.There is a relationship between elevated PSA value and high leukocyte numbers.
