CAJ | 학술논문

目的探讨动脉粥样硬化性脑梗死(ACI)的脂蛋白相关性磷脂酶A2(Lp-PLA2)水平、分析其与相关因素的相关性.方法将56例ACI患者作为观察组,同期选择60例健康体检成人作为对照组,采用酶联免疫法测定两组患者的血浆脂Lp-PLA2水平,按照神经功能缺损程度情况分为轻、中及重型缺损三组,比较三组Lp-PLA2水平.结果观察组与对照组的Lp-PLA2水平分别为(63.39± 11.30) μg/L、(30.68±12.19) μ g/L;轻、中及重型神经功能缺损脑梗死患者的Lp-PLA2水平分别为(56.73±7.19)μg/L、(64.22±6.08)μg/L、(76.51±5.49) μg/L,两两比较P＜0.05.ACI患者血浆中Lp-PLA2水平与患者的性别、年龄、BMI、饮酒、TG、LDL-C呈显著的正相关性,与HDL-C水平呈显著的负相关性.结论 Lp-PLA2是ACI的重要危险因素,其水平可对ACI患者的神经功能缺损程度进行一定指导.
목적 탐토동맥죽양경화성뇌경사(ACI)적지단백상관성린지매A2(Lp-PLA2)수평、분석기여상관인소적상관성.방법 장56례ACI환자작위관찰조,동기선택60례건강체검성인작위대조조,채용매련면역법측정량조환자적혈장지Lp-PLA2수평,안조신경공능결손정도정황분위경、중급중형결손삼조,비교삼조Lp-PLA2수평.결과 관찰조여대조조적Lp-PLA2수평분별위(63.39± 11.30) μg/L、(30.68±12.19) μ g/L;경、중급중형신경공능결손뇌경사환자적Lp-PLA2수평분별위(56.73±7.19)μg/L、(64.22±6.08)μg/L、(76.51±5.49) μg/L,량량비교P＜0.05.ACI환자혈장중Lp-PLA2수평여환자적성별、년령、BMI、음주、TG、LDL-C정현저적정상관성,여HDL-C수평정현저적부상관성.결론 Lp-PLA2시ACI적중요위험인소,기수평가대ACI환자적신경공능결손정도진행일정지도.
Objective To explore the lipoprotein-associated phospholipase A2 (Lp-PLA2) levels in acute atherosclerotic cerebral infarction plasma lipid and their correlation analysis.Methods 56 patients with ACI as the observation group,were compared with 60 cases of healthy adults as control group.Lp-PLA2 levels of all patients were determined by enzyme-linked immunosorbent assay.Patients were divided into three groups of the light,medium and heavy defects in observation group according to the neurological deficits,and compared with Lp-PLA2 levels.Results Lp-PLA2 levels in the observation group and the control group were (63.39 ± 11.30) μ g/L vs (30.68 ± 12.19) μ g/L,Lp-PLA2 levels in light,mediam and heavy-duty brain defect were (56.73 ± 7.19) μ g/L vs (64.22 ± 6.08) μ g/L vs (76.51 ± 5.49) μ g/L,P ＜ 0.05,ACI patients' Lp-PLA2 levels were significantly positively correlated with age,gender,BMI index,alcohol consumption,and TG,LDL-C levels,and significantly negatively correlated with HDL-C level.Conclusion Lp-PLA2 level is an important risk factor for ACI patients,and can guide nerve function defect.