CAJ | 학술논문

目的评价喉罩用于幼猪动物实验中气道管理的效果.方法雄性幼猪72头,2～3月龄,体重22 ～ 32 kg,采用随机数字表法,将其分为2组(n=36):气管插管组(TI组)和喉罩组(LMA组).LMA组置入4#ProSeal喉罩,TI组插入7.0#气管导管.插管成功后,进行间歇正压通气,潮气量8 ～ 10 ml/kg,通气频率16次/min,吸呼比1.0∶1.5,吸入氧浓度50％,氧流量3L/min,维持PETCO2 35 ～ 45mm Hg.麻醉维持:静脉输注丙白酚15 mg·kg-1 ·h-1和瑞芬太尼40 μg·kg-1·h-1,间断静脉注射维库溴铵0.1 mg/kg,通气时间1.5 h.记录插管时间和一次插管成功情况.分别于气管插管或喉罩置入前、气管插管和喉罩置入成功和拔除气管导管或喉罩后即刻记录SpO2,并于上述时点采集动脉血样,进行血气分析.记录咽喉损伤和胃胀气的发生情况.结果与TI组比较,LMA组插管时间缩短,一次插管成功率、气管插管和喉罩置入成功时SpO2和PaO2升高,咽喉损伤发生率和PaCO2降低(P＜0.05),胃胀气发生率差异无统计学意义(P＞0.05).2组幼猪在机械通气期间,SpO2均＞95％,PaO2均＞ 150 mm Hg.结论喉罩通气用于幼猪动物实验气道管理是便捷、有效和安全的方法.
목적 평개후조용우유저동물실험중기도관리적효과.방법 웅성유저72두,2～3월령,체중22 ～ 32 kg,채용수궤수자표법,장기분위2조(n=36):기관삽관조(TI조)화후조조(LMA조).LMA조치입4#ProSeal후조,TI조삽입7.0#기관도관.삽관성공후,진행간헐정압통기,조기량8 ～ 10 ml/kg,통기빈솔16차/min,흡호비1.0∶1.5,흡입양농도50％,양류량3L/min,유지PETCO2 35 ～ 45mm Hg.마취유지:정맥수주병백분15 mg·kg-1 ·h-1화서분태니40 μg·kg-1·h-1,간단정맥주사유고추안0.1 mg/kg,통기시간1.5 h.기록삽관시간화일차삽관성공정황.분별우기관삽관혹후조치입전、기관삽관화후조치입성공화발제기관도관혹후조후즉각기록SpO2,병우상술시점채집동맥혈양,진행혈기분석.기록인후손상화위창기적발생정황.결과 여TI조비교,LMA조삽관시간축단,일차삽관성공솔、기관삽관화후조치입성공시SpO2화PaO2승고,인후손상발생솔화PaCO2강저(P＜0.05),위창기발생솔차이무통계학의의(P＞0.05).2조유저재궤계통기기간,SpO2균＞95％,PaO2균＞ 150 mm Hg.결론 후조통기용우유저동물실험기도관리시편첩、유효화안전적방법.
Objective To evaluate the efficacy of laryngeal mask airway (LMA) for airway management in an experimental piglet model.Methods Seventy-two male piglets,aged 2-3 months,weighing 22-32 kg,were randomly divided into 2 groups (n =36 each):tracheal intubation group (group TI) and LMA group.LMA ProSeal size 4# was placed after induction of anesthesia in group LMA.Endotracheal tube size 7.0# was placed after induction of anesthesia in group TI.Each piglet underwent 1.5 h of intermittent positive pressure ventilation.VT =8-10 ml/kg,RR =16 bpm,I∶ E =1.0∶ 1.5,FiO2 =50％,FGF =3 L/min,and partial pressure of end-tidal carbon dioxide was maintained at 35-45 mm Hg.Anesthesia was maintained with iv infusion of propofol 15 mg· kg-1·h-1 and remifentanil 40 μg· kg-1 · h-1 and intermittent iv boluses of vecuronium 0.1 mg/kg.The intubation time and success rate of intubation at first attempt were recorded.Before intubation or inserting LMA,after successful intubation or LMA placement,and immediately after removal of the endotracheal tube or LMA,SpO2 was recorded and arterial blood samples were collected for blood gas analysis.The injury to throat and flatulence were recorded.Results Compared with group TI,the intubation time was significantly shortened,and the success rate of intubation at first attempt,SpO2 and PaO2 were increased,and the incidence of injury to throat and PaCO2 were decreased in LMA group (P ＜ 0.05).SpO2 was ＞ 95％ and PaO2 ＞ 150 mm Hg during ventilation in both groups.Conclusion The LMA ProSeal can provide adequate ventilation with fewer complications and can be conveniently,safely and effectively used in an experimental piglet model.