中华麻醉学杂志
中華痳醉學雜誌
중화마취학잡지
CHINESE JOURNAL OF ANESTHESIOLOGY
2013年
2期
214-216
,共3页
酰胺类%坐骨神经%神经传导阻滞%剂量效应关系,药物%超声检查%老年人
酰胺類%坐骨神經%神經傳導阻滯%劑量效應關繫,藥物%超聲檢查%老年人
선알류%좌골신경%신경전도조체%제량효응관계,약물%초성검사%노년인
Amides%Sciatic nerve%Nerve block%Dose-response relationship,drug%Ultrasonography%Aged
目的 确定0.375％罗哌卡因用于超声引导臀肌下径路老年患者坐骨神经阻滞的半数有效剂量(ED50).方法 择期在坐骨神经阻滞下行足部或踝部手术的老年患者30例,性别不限,ASA分级Ⅰ～Ⅲ级,年龄65 ～ 85岁,患者取Sims位,于超声引导臀肌下径路实施行坐骨神经阻滞,第1例患者0.375％罗哌卡因初始剂量为14.5 ml,各相邻剂量之间的比值为1.2,采用序贯法计算ED50及95％可信区间.结果 0.375％罗哌卡因用于超声引导臀肌下径路老年患者坐骨神经阻滞的ED50为13.4 ml,95％可信区间为11.5～16.2 ml.结论 0.375％罗哌卡因用于超声引导臀肌下径路老年患者坐骨神经阻滞的ED50为13.4 ml.
目的 確定0.375％囉哌卡因用于超聲引導臀肌下徑路老年患者坐骨神經阻滯的半數有效劑量(ED50).方法 擇期在坐骨神經阻滯下行足部或踝部手術的老年患者30例,性彆不限,ASA分級Ⅰ～Ⅲ級,年齡65 ～ 85歲,患者取Sims位,于超聲引導臀肌下徑路實施行坐骨神經阻滯,第1例患者0.375％囉哌卡因初始劑量為14.5 ml,各相鄰劑量之間的比值為1.2,採用序貫法計算ED50及95％可信區間.結果 0.375％囉哌卡因用于超聲引導臀肌下徑路老年患者坐骨神經阻滯的ED50為13.4 ml,95％可信區間為11.5～16.2 ml.結論 0.375％囉哌卡因用于超聲引導臀肌下徑路老年患者坐骨神經阻滯的ED50為13.4 ml.
목적 학정0.375％라고잡인용우초성인도둔기하경로노년환자좌골신경조체적반수유효제량(ED50).방법 택기재좌골신경조체하행족부혹과부수술적노년환자30례,성별불한,ASA분급Ⅰ～Ⅲ급,년령65 ～ 85세,환자취Sims위,우초성인도둔기하경로실시행좌골신경조체,제1례환자0.375％라고잡인초시제량위14.5 ml,각상린제량지간적비치위1.2,채용서관법계산ED50급95％가신구간.결과 0.375％라고잡인용우초성인도둔기하경로노년환자좌골신경조체적ED50위13.4 ml,95％가신구간위11.5～16.2 ml.결론 0.375％라고잡인용우초성인도둔기하경로노년환자좌골신경조체적ED50위13.4 ml.
Objective To determine the median effective dose (ED50) of 0.375 ％ ropivacaine for ultrasound-guided subgluteus approach to the sciatic nerve block in the elderly patients.Methods Thirty ASA Ⅰ-Ⅲ patients of both sexes,aged 65-85 yr,scheduled for foot or ankle surgery under the sciatic nerve block,were enrolled in this study.The patients were placed in the Sim's position and received the sciatic nerve block using the posterior subgluteus approach guided by ultrasound.The initial dose of 0.375％ ropivacaine was 14.5 ml in the first patient and the ratio between the 2 successive doses was 1.2.The ED50 and 95 ％ confidence interval of ropivacaine were calculated by up-and-down technique.Results The ED50 and 95％ confidence interval of 0.375％ ropivacaine resulting in complete block of the sciatic nerve by using the ultrasound-guided subgluteus approach were 13.4 and 11.5-16.2 ml,respectively.Conclusion The ED50 of 0.375 ％ ropivacaine for ultrasound-guided subgluteus approach to the sciatic nerve block is 13.4 ml in the elderly patients.
