中华麻醉学杂志
中華痳醉學雜誌
중화마취학잡지
CHINESE JOURNAL OF ANESTHESIOLOGY
2013年
3期
293-295
,共3页
林多茂%卢家凯%闫旭明%兰琼%李泽%王慧敏%赵丽云%王义军%卿恩明
林多茂%盧傢凱%閆旭明%蘭瓊%李澤%王慧敏%趙麗雲%王義軍%卿恩明
림다무%로가개%염욱명%란경%리택%왕혜민%조려운%왕의군%경은명
胆碱能拮抗剂%冠状动脉旁路移植术,非体外循环%手术后并发症
膽堿能拮抗劑%冠狀動脈徬路移植術,非體外循環%手術後併髮癥
담감능길항제%관상동맥방로이식술,비체외순배%수술후병발증
Cholinergic antagonists%Coronary artery bypass,off-pump%Postoperative complications
目的 评价术前静脉注射盐酸戊乙奎醚对非停跳冠状动脉搭桥术后患者肺部并发症(PPC)发生的预防效果.方法 非停跳冠状动脉搭桥术患者140例,性别不限,年龄35 ～ 80岁,体重55 ～ 80 kg,ASA分级Ⅱ或Ⅲ级.采用随机数字表法,将其分为2组(n=70):对照组(C组)和盐酸戊乙奎醚组(P组).于气管插管后即刻P组缓慢静脉注射盐酸戊乙奎醚20 μg/kg(5 ml),C组以等容量生理盐水替代.记录术后72 h内患者PPC的发生情况.结果 C组和P组PPC发生率分别为33％和16％.与C组比较,P组PPC发生率降低(P＜0.05).结论 术前静脉注射盐酸戊乙奎醚20 μg/kg可预防非停跳冠状动脉搭桥术患者PPC的发生.
目的 評價術前靜脈註射鹽痠戊乙奎醚對非停跳冠狀動脈搭橋術後患者肺部併髮癥(PPC)髮生的預防效果.方法 非停跳冠狀動脈搭橋術患者140例,性彆不限,年齡35 ～ 80歲,體重55 ～ 80 kg,ASA分級Ⅱ或Ⅲ級.採用隨機數字錶法,將其分為2組(n=70):對照組(C組)和鹽痠戊乙奎醚組(P組).于氣管插管後即刻P組緩慢靜脈註射鹽痠戊乙奎醚20 μg/kg(5 ml),C組以等容量生理鹽水替代.記錄術後72 h內患者PPC的髮生情況.結果 C組和P組PPC髮生率分彆為33％和16％.與C組比較,P組PPC髮生率降低(P＜0.05).結論 術前靜脈註射鹽痠戊乙奎醚20 μg/kg可預防非停跳冠狀動脈搭橋術患者PPC的髮生.
목적 평개술전정맥주사염산무을규미대비정도관상동맥탑교술후환자폐부병발증(PPC)발생적예방효과.방법 비정도관상동맥탑교술환자140례,성별불한,년령35 ～ 80세,체중55 ～ 80 kg,ASA분급Ⅱ혹Ⅲ급.채용수궤수자표법,장기분위2조(n=70):대조조(C조)화염산무을규미조(P조).우기관삽관후즉각P조완만정맥주사염산무을규미20 μg/kg(5 ml),C조이등용량생리염수체대.기록술후72 h내환자PPC적발생정황.결과 C조화P조PPC발생솔분별위33％화16％.여C조비교,P조PPC발생솔강저(P＜0.05).결론 술전정맥주사염산무을규미20 μg/kg가예방비정도관상동맥탑교술환자PPC적발생.
Objective To evaluate the efficacy of penehyelidine hydrochloride for prevention of postoperative pulmonary complications (PPCs) in patients undergoing off-pump coronary artery bypass grafting (OPCABG).Methods One hundred and forty ASAⅡ or Ⅲ patients of both sexes,aged 35-80 yr,weighing 55-80 kg,undergoing OPCABG,were randomly divided into 2 groups (n =70 each):control group (group C) and penehyelidine hydrochloride group (group P).Anesthesia was induced with iv injection of midazolam,etomidate,sufentanil and rocuronium.The patients were mechanically ventilated after tracheal intubation.PET CO2 was maintained at 35-40 mm Hg.Penehyelidine hydrochloride 20μg/kg (5 ml) was injected intravenously and slowly immediately after tracheal intubation in group P.While the equal volume of normal saline was administered instead in group C.Anesthesia was maintained with iv infusion of propofol,intermittent iv boluses of sufentanil and pipecuronium,and inhalation of sevoflurane.BIS value was maintained at 40-50.The occurrence of PPCs was recorded within 72 h after operation.Results The incidences of PPCs were 33％ and 16％ in groups P and C,respectively.The incidence of PPCs was significantly lower in group P than in group C (P ＜ 0.05).Conclusion Intravenous injection of penehyelidine hydrochloride 20μg/kg before operation can prevent the occurrence of PPCs in patients undergoing OPCABG.
