CAJ | 학술논문

目的评价慢性暴露于亚麻醉浓度七氟醚对小鼠记忆功能和内环境稳态的影响.方法清洁级健康昆明种雄性小鼠36只,40 d龄,体重25～30 g,采用随机数字表法,将其分为3组(n=12):正常对照组(C组)、0.1％七氟醚组(L组)和0.5％七氟醚组(H组).每天18:00至6:00吸入七氟醚,持续30 d,L组和H组浓度分别为0.1％和0.5％,吸入27-30 d期间进行水迷宫实验.然后经左心室采集血样,进行血气分析和电解质指标检测.结果 3组小鼠水迷宫实验中游出时间、错误次数及血气分析、电解质指标差异无统计学意义(P＞0.05).结论慢性暴露于亚麻醉浓度七氟醚对小鼠记忆功能及内环境稳态无明显影响.
목적 평개만성폭로우아마취농도칠불미대소서기억공능화내배경은태적영향.방법 청길급건강곤명충웅성소서36지,40 d령,체중25～30 g,채용수궤수자표법,장기분위3조(n=12):정상대조조(C조)、0.1％칠불미조(L조)화0.5％칠불미조(H조).매천18:00지6:00흡입칠불미,지속30 d,L조화H조농도분별위0.1％화0.5％,흡입27-30 d기간진행수미궁실험.연후경좌심실채집혈양,진행혈기분석화전해질지표검측.결과 3조소서수미궁실험중유출시간、착오차수급혈기분석、전해질지표차이무통계학의의(P＞0.05).결론 만성폭로우아마취농도칠불미대소서기억공능급내배경은태무명현영향.
Objective To evaluate the effects of chronic exposure to sub-anesthetic concentrations of sevoflurane on memory function and homeostasis of mice.Methods Thirty-six healthy male Kunming mice,aged 40 days,weighing 25-30 g,were randomly assigned into 3 groups (n =12 each):control group (group C),0.1％ sevoflurane group (group L) and 0.5 ％ sevoflurane group (group H).The mice inhaled 0.1％ (group L) or 0.5％ sevoflurane (group H) between 18:00-6:00 (the next day) every night for 30 days.Water maze test was performed at 27-30 days of inhalation.Blood samples were collected from the left ventricle for blood gas analysis and for determination of blood electrolytes.Results There was no significant difference in swimming time in Water maze test,number of errors and blood gas analysis and blood electrolytes.Conclusion Chronic exposure to subanesthetic concentrations of sevoflurane has no significant effects on memory function and homeostasis of mice.