ERBB2、p-ERK、p-AKT、p-JNK在嗜铬细胞瘤中的表达及意义
ERBB2、p-ERK、p-AKT、p-JNK재기락세포류중적표체급의의
The expression and significance of ERBB2、p-ERK、p-AKT、p-JNK in pheochromocytomas
  • 万方数据
    中华内分泌代谢杂志 중화내분비대사잡지
    CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
    2009年 5期 493-495 ,共3页

    张霞%王峰%袁文祺%何欣%戈岩%苏颋为%周薇薇%崔斌%宁光%王卫庆

    장하%왕봉%원문기%하흔%과암%소정위%주미미%최빈%저광%왕위경

    嗜铬细胞瘤%表皮生长因子受体2%细胞外信号调节激酶%蛋白激酶B%c-Jun氨基端激酶 嗜鉻細胞瘤%錶皮生長因子受體2%細胞外信號調節激酶%蛋白激酶B%c-Jun氨基耑激酶
    기락세포류%표피생장인자수체2%세포외신호조절격매%단백격매B%c-Jun안기단격매
    Pheochromocytomas%ERBB2%Extracellular signal-regulated kinase%Protein kinase B%c-Jan N-terminal kinase
    用免疫组织化学染色方法检测表皮生长因子受体2(ERBB2)在8例恶性嗜铬细胞瘤和31例良性嗜铬细胞瘤组织中的表达.用Western印迹法检测5例ERBB2表达阳性的嗜铬细胞瘤和5例ERBB2表达阴性的嗜铬细胞瘤组织中细胞外信号调节激酶(ERK)、蛋白激酶B(AKT)、c-Jun氨基端激酶(JNK)信号分子的激活情况.结果 提示ERBB2蛋白在恶性嗜铬细胞瘤中高表达(P＜0.01)且可能通过丝裂原活化蛋白激酶(MAPK)/ERK途径,磷脂酰肌醇3激酶(PBK)/AKT途径以及应激活化蛋白激酶(SAPK)/JNK途径导致恶性嗜铬细胞瘤的发生.
    용면역조직화학염색방법검측표피생장인자수체2(ERBB2)재8례악성기락세포류화31례량성기락세포류조직중적표체.용Western인적법검측5례ERBB2표체양성적기락세포류화5례ERBB2표체음성적기락세포류조직중세포외신호조절격매(ERK)、단백격매B(AKT)、c-Jun안기단격매(JNK)신호분자적격활정황.결과 제시ERBB2단백재악성기락세포류중고표체(P＜0.01)차가능통과사렬원활화단백격매(MAPK)/ERK도경,린지선기순3격매(PBK)/AKT도경이급응격활화단백격매(SAPK)/JNK도경도치악성기락세포류적발생.
    The expression of ERBB2 was detected by immunohistochemistry in tissues from 8 patients with malignant pheochromocytoma and 31 with benign pheochromocytoma.Western blotting was used to detect the activation of ERK、 AKT、 JNK in ERBB2-positive as well as ERBB2-negative pheochromocytomas.The results strongly suggest that ERBB2 is overexpressed in malignant pheochromocytoma (P＜0.01),which may lead to malignant pheochromocytoma through MAPK/ERK and PI3K/AKT,and JNK/SPAK pathway.
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