中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2009年
5期
496-497
,共2页
孟晋%蒋怡然%袁文祺%周薇薇%苏颋为%崔斌%王卫庆%宁光
孟晉%蔣怡然%袁文祺%週薇薇%囌颋為%崔斌%王衛慶%寧光
맹진%장이연%원문기%주미미%소정위%최빈%왕위경%저광
嗜铬细胞瘤%鉴别诊断%基因表达谱分析%基因表达
嗜鉻細胞瘤%鑒彆診斷%基因錶達譜分析%基因錶達
기락세포류%감별진단%기인표체보분석%기인표체
Pheochromocytoma%Differential diagnosis%Gene expression profiling%Gene expression
用GeXP(基因表达谱分析)方法,对16例良性嗜铬细胞瘤、14例恶性嗜铬细胞瘤患者的基因表达进行定量分析,发现肽处理相关基因在恶性嗜铬细胞瘤组表达低于良性嗜铬细胞瘤组表达,其中QPCT、HSPA4L、RNF6、RNF128基因表达较低可能提示嗜铬细胞瘤的恶性潜能更大.
用GeXP(基因錶達譜分析)方法,對16例良性嗜鉻細胞瘤、14例噁性嗜鉻細胞瘤患者的基因錶達進行定量分析,髮現肽處理相關基因在噁性嗜鉻細胞瘤組錶達低于良性嗜鉻細胞瘤組錶達,其中QPCT、HSPA4L、RNF6、RNF128基因錶達較低可能提示嗜鉻細胞瘤的噁性潛能更大.
용GeXP(기인표체보분석)방법,대16례량성기락세포류、14례악성기락세포류환자적기인표체진행정량분석,발현태처리상관기인재악성기락세포류조표체저우량성기락세포류조표체,기중QPCT、HSPA4L、RNF6、RNF128기인표체교저가능제시기락세포류적악성잠능경대.
By means of GeXP (gene expression profiling),quantitative analysis was carried out to investigate the gene expression on pheochromocytoma/paraganglioma specimens.30 samples were collectcd from 16 patients with benign pheochromocytoma and 14 with malignant pheochromocytoma/paraganglioma.Our results suggest that lower expressions of genes encoding peptide processing factors including QPCT,HSPA4L,RNF6 and RNF128 in pheochromocytomas/paragangliomas may point to a malignant diagnosis.
