中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2009年
5期
498-500
,共3页
刘玉辉%李玲%高杰清%石英%厉平%姜冉华%刘聪
劉玉輝%李玲%高傑清%石英%厲平%薑冉華%劉聰
류옥휘%리령%고걸청%석영%려평%강염화%류총
糖尿病%2型%一级亲属%胰岛素抵抗%胰岛β细胞功能%葡萄糖钳夹技术
糖尿病%2型%一級親屬%胰島素牴抗%胰島β細胞功能%葡萄糖鉗夾技術
당뇨병%2형%일급친속%이도소저항%이도β세포공능%포도당겸협기술
Diabetes mellitus，type 2%First-degree relatives%Insulin resistance%Islet β-cell function%Glucose clamp technique
目的 研究2型糖尿病患者非糖尿病一级亲属的胰岛素抵抗和胰岛β细胞功能的变化.方法 选取2型糖尿病患者一级亲属23名,其中糖耐量正常者10名(NGT组),糖耐量受损者13名(IGT组).以无糖尿病家族史的糖耐量正常者9名(NC组)为对照.应用高胰岛素-正葡萄糖钳夹技术和静脉葡萄糖耐量试验评估胰岛素抵抗和胰岛β细胞功能.结果 NGT组和IGT组的葡萄糖输注率(mg·kg-1·min-1)分别为(7.04±0.62)和(6.16±0.73),与NC组(10.22±0.93)相比明显降低(均P＜0.05).NGT组的第一时相胰岛素分泌量(对数转换)高于IGT组(3.87±0.24 vs 3.03±0.28,P＜0.05),NC组为(3.37±0.30).NGT组(1.43±0.22)与NC组(1.18±0.41)的葡萄糖处置指数(对数转换)明显高于IGT组(0.32±0.20,P＜0.01或P＜0.05),NC组与NGT组之间差异无统计学意义.结论 2型糖尿病患者非糖尿病一级亲属已经存在胰岛素抵抗,当胰岛素分泌不能代偿抵抗时开始出现糖耐量减退.
目的 研究2型糖尿病患者非糖尿病一級親屬的胰島素牴抗和胰島β細胞功能的變化.方法 選取2型糖尿病患者一級親屬23名,其中糖耐量正常者10名(NGT組),糖耐量受損者13名(IGT組).以無糖尿病傢族史的糖耐量正常者9名(NC組)為對照.應用高胰島素-正葡萄糖鉗夾技術和靜脈葡萄糖耐量試驗評估胰島素牴抗和胰島β細胞功能.結果 NGT組和IGT組的葡萄糖輸註率(mg·kg-1·min-1)分彆為(7.04±0.62)和(6.16±0.73),與NC組(10.22±0.93)相比明顯降低(均P＜0.05).NGT組的第一時相胰島素分泌量(對數轉換)高于IGT組(3.87±0.24 vs 3.03±0.28,P＜0.05),NC組為(3.37±0.30).NGT組(1.43±0.22)與NC組(1.18±0.41)的葡萄糖處置指數(對數轉換)明顯高于IGT組(0.32±0.20,P＜0.01或P＜0.05),NC組與NGT組之間差異無統計學意義.結論 2型糖尿病患者非糖尿病一級親屬已經存在胰島素牴抗,噹胰島素分泌不能代償牴抗時開始齣現糖耐量減退.
목적 연구2형당뇨병환자비당뇨병일급친속적이도소저항화이도β세포공능적변화.방법 선취2형당뇨병환자일급친속23명,기중당내량정상자10명(NGT조),당내량수손자13명(IGT조).이무당뇨병가족사적당내량정상자9명(NC조)위대조.응용고이도소-정포도당겸협기술화정맥포도당내량시험평고이도소저항화이도β세포공능.결과 NGT조화IGT조적포도당수주솔(mg·kg-1·min-1)분별위(7.04±0.62)화(6.16±0.73),여NC조(10.22±0.93)상비명현강저(균P＜0.05).NGT조적제일시상이도소분비량(대수전환)고우IGT조(3.87±0.24 vs 3.03±0.28,P＜0.05),NC조위(3.37±0.30).NGT조(1.43±0.22)여NC조(1.18±0.41)적포도당처치지수(대수전환)명현고우IGT조(0.32±0.20,P＜0.01혹P＜0.05),NC조여NGT조지간차이무통계학의의.결론 2형당뇨병환자비당뇨병일급친속이경존재이도소저항,당이도소분비불능대상저항시개시출현당내량감퇴.
Objective To investigate the insulin resistance and β-cell function in non-diabetic first-degree relatives (FDR) of patients with type 2 diabetes.Methods Of the first-degree relatives of type 2 diabetic patients,10 subjects with normal glucose tolerance(NGT) and 13 with impaired glucose tolerance(IGT) were included.The other 9 healthy subjects without family history of diabetes served as the controls.Insulin resistance was measured by hyperinsulin-euglycemic clamp,and islet β-cell function by intravenous glucose tolerance test (IVGTY).Results NC group(7.04±0.62 and 6.16±0.73 vs 10.22±0.93,both P＜0.05).There was no difference in GIR between the former two groups.The first phase insulin secretion (natural logarithm transformed data) of the NGT group was higher than that of IGT group(3.87±0.24 vs 3.03±0.28,P＜0.05),but not significant with that of NC group (3.37±0.30).The results of the disposition index (DI,natural logarithm transformed data)in NGT group (1.43 ±0.22) and NC group(1.18±0.41) were greater than that in IGT group (0.32±0.20,P＜0.01 or P＜0.05).No difference existed between IGT and NC groups.Conclusions Insulin resistance emerges in non-diabetic firstdegree relatives of patients with type 2 diabetes while glucose tolerance remains normal.Blood glucose rises only when β-cell function fails to compensate.
