中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2009年
6期
604-607
,共4页
张杉杉%顾雪明%刘宏%周云飞%蔡慧丽%顾俊义%施建元%徐茜%汤正义%宁光
張杉杉%顧雪明%劉宏%週雲飛%蔡慧麗%顧俊義%施建元%徐茜%湯正義%寧光
장삼삼%고설명%류굉%주운비%채혜려%고준의%시건원%서천%탕정의%저광
糖尿病足%白蛋白%血红蛋白%甲状腺功能
糖尿病足%白蛋白%血紅蛋白%甲狀腺功能
당뇨병족%백단백%혈홍단백%갑상선공능
Diabetic foot%Albumin%Hemoglobin%Thyroid function
目的 分析糖尿病足病病情严重件与全身状态和甲状腺功能指标的相关性,探讨足病不同状态的严重性和需要注意的指标.方法 95例糖尿病足病和31例足病高危患者,根据Wagner分级分为6组,分别统计分析他们的糖尿病病情、血浆白蛋白、 血液中血红蛋白、尿蛋白、血清肌酐和甲状腺功能指标,观察这些指标与Wagner分级的关系.结果 随着糖尿病足病Wagner级别增加,平均HbA_(1C)水平上升,内源性胰岛素分泌减少,血液中自蛋白与血红蛋白含量逐渐下降,尿蛋白排出逐级上升,血液中T_3、T_4、FT_3水平也不断下降.这些指标在各Wagner级别组间有显著差别(均P<0.05):到Wagner4级以上,它们具体数值改变更显著,与Wagner0和1级的比较差异有统计学意义(均P<0.05);等级相父性分析显示这些指标与Wagner分级呈显著相关性(均P<0.05);其中HbA_(1C)和甲状腺功能是糖尿病足病病情严重性的主要相关因素.结论 Wagner4级以上糖尿病足病患者病情已经达到危重状态,提示需要全面干预.
目的 分析糖尿病足病病情嚴重件與全身狀態和甲狀腺功能指標的相關性,探討足病不同狀態的嚴重性和需要註意的指標.方法 95例糖尿病足病和31例足病高危患者,根據Wagner分級分為6組,分彆統計分析他們的糖尿病病情、血漿白蛋白、 血液中血紅蛋白、尿蛋白、血清肌酐和甲狀腺功能指標,觀察這些指標與Wagner分級的關繫.結果 隨著糖尿病足病Wagner級彆增加,平均HbA_(1C)水平上升,內源性胰島素分泌減少,血液中自蛋白與血紅蛋白含量逐漸下降,尿蛋白排齣逐級上升,血液中T_3、T_4、FT_3水平也不斷下降.這些指標在各Wagner級彆組間有顯著差彆(均P<0.05):到Wagner4級以上,它們具體數值改變更顯著,與Wagner0和1級的比較差異有統計學意義(均P<0.05);等級相父性分析顯示這些指標與Wagner分級呈顯著相關性(均P<0.05);其中HbA_(1C)和甲狀腺功能是糖尿病足病病情嚴重性的主要相關因素.結論 Wagner4級以上糖尿病足病患者病情已經達到危重狀態,提示需要全麵榦預.
목적 분석당뇨병족병병정엄중건여전신상태화갑상선공능지표적상관성,탐토족병불동상태적엄중성화수요주의적지표.방법 95례당뇨병족병화31례족병고위환자,근거Wagner분급분위6조,분별통계분석타문적당뇨병병정、혈장백단백、 혈액중혈홍단백、뇨단백、혈청기항화갑상선공능지표,관찰저사지표여Wagner분급적관계.결과 수착당뇨병족병Wagner급별증가,평균HbA_(1C)수평상승,내원성이도소분비감소,혈액중자단백여혈홍단백함량축점하강,뇨단백배출축급상승,혈액중T_3、T_4、FT_3수평야불단하강.저사지표재각Wagner급별조간유현저차별(균P<0.05):도Wagner4급이상,타문구체수치개변경현저,여Wagner0화1급적비교차이유통계학의의(균P<0.05);등급상부성분석현시저사지표여Wagner분급정현저상관성(균P<0.05);기중HbA_(1C)화갑상선공능시당뇨병족병병정엄중성적주요상관인소.결론 Wagner4급이상당뇨병족병환자병정이경체도위중상태,제시수요전면간예.
Objective To analyze the relations of thyroid function and general body status to the Wagner grades of diabetic foot disease(DFD),and to investigate the indicators of severity to DFD.Methods Ninety-five patients with confirmed DFD and 31 patients with high risk factors to DFD were classified into 6 groups according to Wagner grades.Their HbA_(1C),C-peptides,serum albumin,blood hemoglobin,24 h urine protein excretion,serum creatinine,functional parameters of thyroid,and dependability to Wagner grades were analyzed.Results With increasing of Wagner grades,HbA_(1C) and 24 h urine albumin excretion were increased gradually.Intrinsic insulin secretion,serum albumin,blood hemoglobin,T_3,T_4,and FT_3 were decreased.These indicators had significant differences among Wagner grades(all P<0.05).In the patients of Wagner 4 and 5,these indicators were apparently abnormal,which had remarkable discrepancies compared to Wagner 0 and 1(all P<0.05).They had distinct dependability to Wagner grades(all P<0.05).Among them,HbA_(1C) and parameters of thyroid function were the main correlation factors.Conclusion In patients with Wagner 4 and 5,DFD has attained a highly severe status and the treatment of DFD should be imminent and intensive.
