中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2011年
1期
36-39
,共4页
马晓宇%倪继红%刘玥隽%陈少科%王伟
馬曉宇%倪繼紅%劉玥雋%陳少科%王偉
마효우%예계홍%류모준%진소과%왕위
Kisspeptin%特发性中枢性性早熟%单纯性乳房早发育%Tanner分期%女性
Kisspeptin%特髮性中樞性性早熟%單純性乳房早髮育%Tanner分期%女性
Kisspeptin%특발성중추성성조숙%단순성유방조발육%Tanner분기%녀성
Kisspeptin%Idiopathic central precocious puberty%Premature thelarche%Tanner stages%Female
目的 研究女童特发性中枢性性早熟(ICPP)及正常女性青春发育各期血浆kisspeptin水平,并探讨以此鉴别ICPP和单纯性乳房早发育(premature thelarche,PT)的意义.方法 女童共92名,女青年18名,其中ICPP 10例、PT12例、正常青春发育Tanner Ⅰ～Ⅴ期各16～19名.采用酶联免疫吸附方法(ELISA)检测血浆kisspeptin.结果 血浆kisspeptin水平ICPP组明显高于PT组[(1.73±0.23对1.43±0.29)ng/ml,P＜0.05];正常青春发育kisspeptin水平从Tanner Ⅱ期至Tanner Ⅴ期逐渐下降,其中以Tanner Ⅱ期最高;Tanner Ⅳ、Ⅴ期明显低于TannerⅠ、Ⅲ期(P＜0.01).结论 正常女性青春发育期血浆kisspeptin 水平以TannerⅡ期最高,检测其水平对于临床鉴别ICPP与PT有一定意义.
目的 研究女童特髮性中樞性性早熟(ICPP)及正常女性青春髮育各期血漿kisspeptin水平,併探討以此鑒彆ICPP和單純性乳房早髮育(premature thelarche,PT)的意義.方法 女童共92名,女青年18名,其中ICPP 10例、PT12例、正常青春髮育Tanner Ⅰ～Ⅴ期各16～19名.採用酶聯免疫吸附方法(ELISA)檢測血漿kisspeptin.結果 血漿kisspeptin水平ICPP組明顯高于PT組[(1.73±0.23對1.43±0.29)ng/ml,P＜0.05];正常青春髮育kisspeptin水平從Tanner Ⅱ期至Tanner Ⅴ期逐漸下降,其中以Tanner Ⅱ期最高;Tanner Ⅳ、Ⅴ期明顯低于TannerⅠ、Ⅲ期(P＜0.01).結論 正常女性青春髮育期血漿kisspeptin 水平以TannerⅡ期最高,檢測其水平對于臨床鑒彆ICPP與PT有一定意義.
목적 연구녀동특발성중추성성조숙(ICPP)급정상녀성청춘발육각기혈장kisspeptin수평,병탐토이차감별ICPP화단순성유방조발육(premature thelarche,PT)적의의.방법 녀동공92명,녀청년18명,기중ICPP 10례、PT12례、정상청춘발육Tanner Ⅰ～Ⅴ기각16～19명.채용매련면역흡부방법(ELISA)검측혈장kisspeptin.결과 혈장kisspeptin수평ICPP조명현고우PT조[(1.73±0.23대1.43±0.29)ng/ml,P＜0.05];정상청춘발육kisspeptin수평종Tanner Ⅱ기지Tanner Ⅴ기축점하강,기중이Tanner Ⅱ기최고;Tanner Ⅳ、Ⅴ기명현저우TannerⅠ、Ⅲ기(P＜0.01).결론 정상녀성청춘발육기혈장kisspeptin 수평이TannerⅡ기최고,검측기수평대우림상감별ICPP여PT유일정의의.
Objective To investigate the pattern of plasma kisspeptin levels in normal female during various pubertal Tanner stages and the girls with idiopathic central precocious puberty(ICPP) or with premature thelarche(PT), and to evaluate the significance of detecting plasma kisspeptin levels as a new criterion for early differentiation between ICPP and PT.Methods Each study group of normal pubertal females with Tanner stage Ⅰ to Ⅴ comprised 16 to 19 individuals.The levels of plasma kisspeptin were also detected in girls with ICPP(n= 10)or PT(n = 12).The plasma kisspeptin levels were detected by enzyme-linked immunosorbent assay (ELISA).Results The level of kisspeptin was significantly higher in ICPP group than in that of PT group [(1.73±0.23 vs1.43±0.29) ng/ml, P＜0.05].Among the normal pubertal females, the level of kisspeptin decreased gradually from Tanner stage Ⅱ to Tanner stage Ⅴ, being highest in Tanner stage Ⅱ [(1.73±0.22) ag/ml] ,lower in stage Ⅳ and Ⅴ than in stage Ⅰ and Ⅲ (P＜0.01).Conclusions Plasma kisspeptin level was the highest during Tanner stage Ⅱ in normal female pubertal development.It is significant to detect plasma kisspeptin level for the differential diagnosis of ICPP and PT.
