CAJ | 학술논문

运动可改善糖尿病和肥胖等代谢性疾病的机制一直不甚明了,直到肌肉组织分泌的一种新激素Irisin被发现.目前的研究已表明,Irisin可以促进脂肪组织消耗能量,降低体重,并减轻饮食诱发的胰岛素抵抗,改善血糖.耐力运动可以明显增加血浆中Irisin水平,这也表明运动与代谢之间存在明确的联系.鉴于其对肥胖和胰岛素抵抗的作用,Irisin有可能用于治疗肥胖和2型糖尿病.
운동가개선당뇨병화비반등대사성질병적궤제일직불심명료,직도기육조직분비적일충신격소Irisin피발현.목전적연구이표명,Irisin가이촉진지방조직소모능량,강저체중,병감경음식유발적이도소저항,개선혈당.내력운동가이명현증가혈장중Irisin수평,저야표명운동여대사지간존재명학적련계.감우기대비반화이도소저항적작용,Irisin유가능용우치료비반화2형당뇨병.
The mechanisms underlying the therapeutic effects of exercise on obesity and type 2 diabetes remained unknown until irisin,a novel hormone secreted from muscle tissue,was identified.Irisin increases total energy expenditure,reduces body weight,and mitigates diet-induced insulin resistance,thus improving glycemic control.Interestingly,the concentration of irisin increases significantly after endurance exercise,suggesting there is an association between exercise and metabolism.Given its antiobesity and antidiabetic effects,irisin has been postulated to serve as an injectable treatment for metabolic disease including obesity and type 2 diabetes.