CAJ | 학술논문

以2 544名健康体检人群为研究对象,检测受试者血糖、血脂、血清谷丙转氨酶(ALT)、谷草转氨酶(AST)等相关生化指标.将研究对象按非酒精性脂肪肝纤维化评分(NAFLDFS)的低诊断阈值(-1.455)分成NAFLDFS＜-1.455组(A组)和NAFLDFS≥-1.455组(B组).结果显示,B组患者年龄、体重、体重指数、腰围、臀围、体脂率、收缩压、舒张压、空腹血糖、餐后2h血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、ALT、AST、腰臀比水平均高于A组(P＜0.05或P＜0.01).B组患者代谢综合征、肥胖、高血压、高血糖患病率较A组均明显升高(P＜0.01).肝纤维化发生率随着代谢综合征组分的增加而增加.提示NAFLDFS是临床较为实用的评估代谢综合征的指标.
이2 544명건강체검인군위연구대상,검측수시자혈당、혈지、혈청곡병전안매(ALT)、곡초전안매(AST)등상관생화지표.장연구대상안비주정성지방간섬유화평분(NAFLDFS)적저진단역치(-1.455)분성NAFLDFS＜-1.455조(A조)화NAFLDFS≥-1.455조(B조).결과현시,B조환자년령、체중、체중지수、요위、둔위、체지솔、수축압、서장압、공복혈당、찬후2h혈당、총담고순、감유삼지、저밀도지단백담고순、ALT、AST、요둔비수평균고우A조(P＜0.05혹P＜0.01).B조환자대사종합정、비반、고혈압、고혈당환병솔교A조균명현승고(P＜0.01).간섬유화발생솔수착대사종합정조분적증가이증가.제시NAFLDFS시림상교위실용적평고대사종합정적지표.
[Summary] A total of 2 544 subjects from a community-based health examination survey were included in the present study.Blood glucose,blood lipid,serum alanine aminotransferase (ALT),and aspartate aminotransferase (AST) were determined.The subjects were divided into nonalcoholic fatty liver disease fibrosis score (NAFLDFS) ＜-1.455 group (A group) and NAFLDFS ≥-1.455 group (B group) based on the low cutoff of NAFLDFS (-1.455).The results showed that age,body weight,body mass index,waist circumference,hip circumference,body fat,systolic blood pressure,diastolic blood pressure,fasting blood glucose,postprandial 2 h blood glucose,total cholesterol,triglyceride,low density lipoprotein-cholesterol,ALT,AST,and waist-hip ratio in B group were higher than those in A group (P＜0.05 or P＜0.01).The prevalences of metabolic syndrome,obesity,hypertension,and hyperglycemia were significantly increased in B group compared with A group (P＜0.01).The incidence of liver fibrosis increased with the increase of the components of metabolic syndrome.These results suggest that NAFLDFS is a useful clinical index in evaluating metabolic syndrome.