CAJ | 학술논문

目的分析1型糖尿病患者维生素D的水平,并探讨维生素D与1型糖尿病患者胰岛β细胞功能的关系.方法选取2011年1月至2012年4月就诊的1型糖尿病患者65例、正常糖耐量者78例,以及HbA1C、血糖水平及糖尿病病程与1型糖尿病组匹配的2型糖尿病患者87例,比较3组之间血清25-羟维生素D3[25(OH) D3]水平的差别.将1型糖尿病组的空腹C肽水平与其他变量进行Pearson相关分析,然后将所有P＜0.05的因素纳入多元逐步直线回归分析.结果 1型糖尿病患者血清25 (OH) D3水平显著低于正常糖耐量组及2型糖尿病组[7.7(4.8 ～14.9)对13.9(10.0 ～ 17.9),12.5(9.3 ～17.4)ng/mg,均P＜0.O1].多元逐步直线回归分析显示1型糖尿病组空腹C肽浓度与25 (OH)D3水平独立相关.结论 1型糖尿病患者维生素D水平显著低于正常糖耐量人群和2型糖尿病患者,1型糖尿病患者维生素D水平与β细胞功能呈独立正相关,对1型糖尿病患者是否需补充维生素D是一个值得研究的课题.
목적 분석1형당뇨병환자유생소D적수평,병탐토유생소D여1형당뇨병환자이도β세포공능적관계.방법 선취2011년1월지2012년4월취진적1형당뇨병환자65례、정상당내량자78례,이급HbA1C、혈당수평급당뇨병병정여1형당뇨병조필배적2형당뇨병환자87례,비교3조지간혈청25-간유생소D3[25(OH) D3]수평적차별.장1형당뇨병조적공복C태수평여기타변량진행Pearson상관분석,연후장소유P＜0.05적인소납입다원축보직선회귀분석.결과 1형당뇨병환자혈청25 (OH) D3수평현저저우정상당내량조급2형당뇨병조[7.7(4.8 ～14.9)대13.9(10.0 ～ 17.9),12.5(9.3 ～17.4)ng/mg,균P＜0.O1].다원축보직선회귀분석현시1형당뇨병조공복C태농도여25 (OH)D3수평독립상관.결론 1형당뇨병환자유생소D수평현저저우정상당내량인군화2형당뇨병환자,1형당뇨병환자유생소D수평여β세포공능정독립정상관,대1형당뇨병환자시부수보충유생소D시일개치득연구적과제.
Objective To determine vitamin D levels in patients with type 1 diabetes mellitus (T1DM),and to explore the relationship of vitamin D and pancreatic β-cell function in these patients.Methods Sixty-five patients with T1DM,78 controls with normal glucose tolerance (NGT),as well as 87 type 2 diabetes mellitus (T2DM) patients,whose HbA1C,blood glucose levels,and duration of diabetes were matched with those in the T1 DM group,were enrolled from January 2011 to April 2012.The differences in serum 25-hydroxyvitamin D3 [25 (OH) D3] levels among the three groups were compared.Pearson correlation analysis was used for investigating the relationship between fasting C-peptide levels and other variables in T1DM group,all P＜0.05 variables then were included in a stepwise multiple linear regression analysis.Results Serum 25 (OH) D3 levels were significantly lower in T1 DM group than those in NGT and T2DM groups [7.7 (4.8-14.9)vs 13.9 (10.0-17.9),12.5 (9.3-17.4)ng/mg,both P＜0.01].Stepwise multiple linear regression analysis showed that fasting serum C-peptide concentration was independently associated with serum 25 (OH) D3 level in T1 DM group.Conclusions T1DM patients had lower vitamin D levels than NGT and T2DM subjects,vitamin D status showed independently a positive association with β-cell function in T1DM patients.Whether supplement of vitamin D to TIDM patients is a topic worth studying.