中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
10期
836-839
,共4页
马笑堃%李志臻%秦贵军%刘会苗%任高飞
馬笑堃%李誌臻%秦貴軍%劉會苗%任高飛
마소곤%리지진%진귀군%류회묘%임고비
糖尿病,2型%维生素D%甲状旁腺激素%动脉硬化
糖尿病,2型%維生素D%甲狀徬腺激素%動脈硬化
당뇨병,2형%유생소D%갑상방선격소%동맥경화
Diabetes mellitus,type 2%Vitamin D%Parathyroid hormone%Arterial stiffness
目的 评价血清25-羟维生素D3 [25(OH)D3]、甲状旁腺激素(PTH)水平与2型糖尿病动脉硬化的相关性.方法 选取2011年10月至2012年2月住院,年龄大于30岁的2型糖尿病患者258例,测定血清25(OH)D3、PTH以及HbA1C、血脂、血清钙、超敏C反应蛋白等指标.动脉硬化的评价指标采用自动波分析仪VP-1000测定踝臂指数、脉搏波传导速度.结果 (1)2型糖尿病25(OH)D3缺乏的患病率为79.84％ (206/258)；(2)维生素D缺乏组较非维生素D缺乏组脉搏波传导速度高[(1610.76±142.70对1527.95±58.02) cm/s,P＜0.05]；(3)多元线性逐步回归分析显示,25(OH)D3是独立于年龄、收缩压、糖尿病病程,影响脉搏波传导速度的危险因素(β=-0.256,P＜0.01)；(4)PTH与脉搏波传导速度、收缩压正相关(r分别为0.210,0.229,P＜0.05),与25(OH)D3负相关(r=-0.153,P＜0.05).结论 2型糖尿病患者25(OH)D3缺乏的情况较为普遍,其25 (OH)D3水平与动脉硬化独立相关.PTH可能是通过25 (OH)D3和血压与动脉硬化相关.
目的 評價血清25-羥維生素D3 [25(OH)D3]、甲狀徬腺激素(PTH)水平與2型糖尿病動脈硬化的相關性.方法 選取2011年10月至2012年2月住院,年齡大于30歲的2型糖尿病患者258例,測定血清25(OH)D3、PTH以及HbA1C、血脂、血清鈣、超敏C反應蛋白等指標.動脈硬化的評價指標採用自動波分析儀VP-1000測定踝臂指數、脈搏波傳導速度.結果 (1)2型糖尿病25(OH)D3缺乏的患病率為79.84％ (206/258)；(2)維生素D缺乏組較非維生素D缺乏組脈搏波傳導速度高[(1610.76±142.70對1527.95±58.02) cm/s,P＜0.05]；(3)多元線性逐步迴歸分析顯示,25(OH)D3是獨立于年齡、收縮壓、糖尿病病程,影響脈搏波傳導速度的危險因素(β=-0.256,P＜0.01)；(4)PTH與脈搏波傳導速度、收縮壓正相關(r分彆為0.210,0.229,P＜0.05),與25(OH)D3負相關(r=-0.153,P＜0.05).結論 2型糖尿病患者25(OH)D3缺乏的情況較為普遍,其25 (OH)D3水平與動脈硬化獨立相關.PTH可能是通過25 (OH)D3和血壓與動脈硬化相關.
목적 평개혈청25-간유생소D3 [25(OH)D3]、갑상방선격소(PTH)수평여2형당뇨병동맥경화적상관성.방법 선취2011년10월지2012년2월주원,년령대우30세적2형당뇨병환자258례,측정혈청25(OH)D3、PTH이급HbA1C、혈지、혈청개、초민C반응단백등지표.동맥경화적평개지표채용자동파분석의VP-1000측정과비지수、맥박파전도속도.결과 (1)2형당뇨병25(OH)D3결핍적환병솔위79.84％ (206/258)；(2)유생소D결핍조교비유생소D결핍조맥박파전도속도고[(1610.76±142.70대1527.95±58.02) cm/s,P＜0.05]；(3)다원선성축보회귀분석현시,25(OH)D3시독립우년령、수축압、당뇨병병정,영향맥박파전도속도적위험인소(β=-0.256,P＜0.01)；(4)PTH여맥박파전도속도、수축압정상관(r분별위0.210,0.229,P＜0.05),여25(OH)D3부상관(r=-0.153,P＜0.05).결론 2형당뇨병환자25(OH)D3결핍적정황교위보편,기25 (OH)D3수평여동맥경화독립상관.PTH가능시통과25 (OH)D3화혈압여동맥경화상관.
Objective To evaluate the association between serum 25-hydroxyvitamin D3 [25 (OH) D3],parathyroid hormone,and arterial stiffness in patients with type 2 diabetes.Methods Serum 25 (OH) D3 and parathyroid hormone(PTH) were determined in a cross-sectional sample of 258 patients aged 30 years and over.Arterial stiffness was assessed by pulse wave velocity(PWV) obtained with a VP-1000 pulse wave unit.Fasting plasma HbA1c,lipid profile,calcium,and high sensitive-C reactive protein were determined.Results (1)The prevalence of vitamin D3 deficiency was high(79.84％) in patients with type 2 diabetes.(2) Those with lowered serum vitamin D3 levels had raised PWV [(1610.76 ± 142.70 vs 1527.95 ± 58.02) cm/s,P＜0.05].(3) Multiple stepwise regression analysis showed that 25 (OH) D3 was an impact factor of PWV risk score,which was independent of age,duration of diabetes,and systolic blood pressure(β =-0.256,P＜0.01).(4) Serum PTH was positively correlated with PWV (r =0.210,P ＜ 0.05) and systolic blood pressure (r =0.229,P ＜ 0.05),but negatively correlated with 25 (OH) D3 (r =-0.153,P ＜ 0.05).Conclusions 25 (OH) D3 deficiency is common in patients with type 2diabetes,and a low serum 25 (OH) D3 level is significantly associated with increased arterial stiffness in these patients.The association of serum PTH with arterial stiffness may result via changes in vitamin D and blood pressure.
