中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
10期
840-845
,共6页
林寰东%高键%马慧%李小明%宋斌斌%潘柏申%盛建华%陈旭昇%高鑫
林寰東%高鍵%馬慧%李小明%宋斌斌%潘柏申%盛建華%陳旭昇%高鑫
림환동%고건%마혜%리소명%송빈빈%반백신%성건화%진욱승%고흠
25-羟维生素D%代谢综合征%甲状旁腺素%骨矿含量
25-羥維生素D%代謝綜閤徵%甲狀徬腺素%骨礦含量
25-간유생소D%대사종합정%갑상방선소%골광함량
25-hydroxyvitamin D%Metabolic syndrome%Parathyroid hormone%Bone mineral content
目的 探讨维生素D与代谢综合征之间的关系.方法 对536名45岁以上来自上海长风社区人群进行横断面问卷调查,形体测量,检测血脂、空腹血糖、糖负荷后2h血糖,25-羟维生素D[25(OH)D]和甲状旁腺素(PTH).采用双能X线吸收法测定骨矿含量.代谢综合征诊断采用国际糖尿病联盟(IDF)标准.结果 代谢综合征的检出率为35.6％.与非代谢综合征组相比,代谢综合征组的25(OH)D水平降低[(42.53±13.58对46.72±16.83)nmol/L,P=0.004],PTH水平升高[(41.61±14.06对39.25±12.93)mmol/L,P=0.050].按25(OH)D水平由高到低三分位分组后,代谢综合征的检出率逐步增高(分别为29.1％,38.9％和40.0％,趋势P=0.035).与最高组(≥49.75 nmol/L)相比,中间组(37.38 ～49.75 nmol/L)和最低组(≤37.38 nmol/L)发生代谢综合征的比值比(OR)分别为1.049(95％ CI0.683～1.610)和1.621(95％ CI1.040～2.532).Logistic回归分析分别校正代谢综合征组分、PTH和骨矿含量后显示25(OH)D水平与代谢综合征呈负相关(OR=0.975,95％ CI0.957 ～0.994).结论 25(OH)D水平降低是除腰围、空腹血糖和甘油三酯等传统因素以及PTH和骨矿含量以外,可能为发生代谢综合征的独立危险因素.
目的 探討維生素D與代謝綜閤徵之間的關繫.方法 對536名45歲以上來自上海長風社區人群進行橫斷麵問捲調查,形體測量,檢測血脂、空腹血糖、糖負荷後2h血糖,25-羥維生素D[25(OH)D]和甲狀徬腺素(PTH).採用雙能X線吸收法測定骨礦含量.代謝綜閤徵診斷採用國際糖尿病聯盟(IDF)標準.結果 代謝綜閤徵的檢齣率為35.6％.與非代謝綜閤徵組相比,代謝綜閤徵組的25(OH)D水平降低[(42.53±13.58對46.72±16.83)nmol/L,P=0.004],PTH水平升高[(41.61±14.06對39.25±12.93)mmol/L,P=0.050].按25(OH)D水平由高到低三分位分組後,代謝綜閤徵的檢齣率逐步增高(分彆為29.1％,38.9％和40.0％,趨勢P=0.035).與最高組(≥49.75 nmol/L)相比,中間組(37.38 ～49.75 nmol/L)和最低組(≤37.38 nmol/L)髮生代謝綜閤徵的比值比(OR)分彆為1.049(95％ CI0.683～1.610)和1.621(95％ CI1.040～2.532).Logistic迴歸分析分彆校正代謝綜閤徵組分、PTH和骨礦含量後顯示25(OH)D水平與代謝綜閤徵呈負相關(OR=0.975,95％ CI0.957 ～0.994).結論 25(OH)D水平降低是除腰圍、空腹血糖和甘油三酯等傳統因素以及PTH和骨礦含量以外,可能為髮生代謝綜閤徵的獨立危險因素.
목적 탐토유생소D여대사종합정지간적관계.방법 대536명45세이상래자상해장풍사구인군진행횡단면문권조사,형체측량,검측혈지、공복혈당、당부하후2h혈당,25-간유생소D[25(OH)D]화갑상방선소(PTH).채용쌍능X선흡수법측정골광함량.대사종합정진단채용국제당뇨병련맹(IDF)표준.결과 대사종합정적검출솔위35.6％.여비대사종합정조상비,대사종합정조적25(OH)D수평강저[(42.53±13.58대46.72±16.83)nmol/L,P=0.004],PTH수평승고[(41.61±14.06대39.25±12.93)mmol/L,P=0.050].안25(OH)D수평유고도저삼분위분조후,대사종합정적검출솔축보증고(분별위29.1％,38.9％화40.0％,추세P=0.035).여최고조(≥49.75 nmol/L)상비,중간조(37.38 ～49.75 nmol/L)화최저조(≤37.38 nmol/L)발생대사종합정적비치비(OR)분별위1.049(95％ CI0.683～1.610)화1.621(95％ CI1.040～2.532).Logistic회귀분석분별교정대사종합정조분、PTH화골광함량후현시25(OH)D수평여대사종합정정부상관(OR=0.975,95％ CI0.957 ～0.994).결론 25(OH)D수평강저시제요위、공복혈당화감유삼지등전통인소이급PTH화골광함량이외,가능위발생대사종합정적독립위험인소.
Objective To explore the relationship between vitamin D and metabolic syndrome.Methods A total of 536 subjects aged over 45 years old from Shanghai Changfeng community were included.A standard questionnaire,anthropometric parameters,and blood analysis,including lipid,fasting plasma glucose,2 h plasma glucose after oral glucose tolerance test,25-hydroxyvitamin D [25 (OH) D],and parathyroid hormone (PTH) were conducted.Bone mineral content was examined using dual energy X-ray assay.Metabolic syndrome was diagnosed according to the International Diabetes Federation (IDF) criteria.Results Altogelher,35.6％ of 536 subjects developed metabolic syndrome.Subjects with metabolic syndrome had lower 25 (OH) D and higher PTH concentration than those individuals without metabolic syndrome [25 (OH) D:(42.53 ± 13.58 vs 46.72 ± 16.83) nmol/L,P =0.004; PTH:(41.61 ± 14.06 vs 39.25 ± 12.93) mmol/L,P =0.050].From the highest to the lowest tertile of 25(OH)D,29.1％,38.9％,and 40.0％ of participants,respectively,had metabolic syndrome (Ptrend =0.035).Compared with the highest tertile of 25 (OH) D,the odds ratios (OR) for metabolic syndrome in the middle and lowest tertile were 1.049 (95％ CI 0.683-1.610) and 1.621 (95％ CI 1.040-2.532) respectively.Logistic regression analysis revealed that metabolic syndrome was associated with lowered 25 (OH) D (OR =0.975,95％ CI 0.957-0.994) after adjusted for simple component of metabolic syndrome,PTH,and bone mineral content.Conclusions Lowered 25 (OH) D level seems to be a risk factor for metabolic syndrome,independent of traditional risk factor,such as waist circumference,fasting glucose,triglyceride,PTH,and bone mineral content.
