CAJ | 학술논문

链脲佐菌素注射制备SD大鼠糖尿病模型,分为正常血糖对照组、糖尿病对照组、胰岛素治疗组.12周后,糖尿病组左心室压力上升最大速率和下降最大速率均明显降低(P＜0.05),而胰岛素治疗组则较糖尿病组增高(P＜0.05).糖尿病组心肌局部血流量明显低于对照组[(3.39±0.48对3.90±0.45)ml·g-1·min-1,p＜0.05],而胰岛素治疗组明显高于糖尿病组[(4.46±0.52对3.39±0.48)ml·g-1·min-1,P＜0.05].糖尿病组毛细血管密度比值低于对照组[0.429±0.091对0.545 ±0.082,P＜0.05],胰岛素治疗组则高于糖尿病组[0.494 ±0.076对0.429 ±0.091,P＜0.05].胰岛素治疗组的VEGF和Ang-1表达较其他两组明显增多(P＜0.05).提示胰岛素治疗可以提高糖尿病心肌病大鼠心肌组织的血管生成及增加局部心肌组织的血流量.
련뇨좌균소주사제비SD대서당뇨병모형,분위정상혈당대조조、당뇨병대조조、이도소치료조.12주후,당뇨병조좌심실압력상승최대속솔화하강최대속솔균명현강저(P＜0.05),이이도소치료조칙교당뇨병조증고(P＜0.05).당뇨병조심기국부혈류량명현저우대조조[(3.39±0.48대3.90±0.45)ml·g-1·min-1,p＜0.05],이이도소치료조명현고우당뇨병조[(4.46±0.52대3.39±0.48)ml·g-1·min-1,P＜0.05].당뇨병조모세혈관밀도비치저우대조조[0.429±0.091대0.545 ±0.082,P＜0.05],이도소치료조칙고우당뇨병조[0.494 ±0.076대0.429 ±0.091,P＜0.05].이도소치료조적VEGF화Ang-1표체교기타량조명현증다(P＜0.05).제시이도소치료가이제고당뇨병심기병대서심기조직적혈관생성급증가국부심기조직적혈류량.
Diabetic SD rats were established by injection of streptozotocin,and were divided into normal blood sugar control group(NC),diabetic control group(DM),and the insulin treatment group(IDM).12 weeks later,the maximum rates of increasing and decreasing pressure in left ventricle were both decreased in DM group(P＜ 0.05),and those in IDM group were higher than those in DM group(P＜0.05).Regional myocardial blood flow in DM group was lower than that in NC group [(3.39 ± 0.48 vs 3.90 ± 0.45) ml · g-1 · min-1,P＜ 0.05],and that in IDM group was higher than that in DM group [(4.46 ± 0.52 vs 3.39 ± 0.48) ml · g-1 · min-1,P＜0.05].The capillary density ratio in DM group was lower than that of NC group [0.429 ± 0.091 vs 0.545 ± 0.082,P＜0.05],but that in IDM group was higher than DM group [0.494 ± 0.076 vs 0.429 ± 0.091,P＜0.05].VEGF and Ang-1 expression in DM group were the highest in 3 groups (P＜0.05).Insulin therapy may improve the angiogenesis and myocardial blood flow in diabetic rats with cardiomyopathy.