CAJ | 학술논문

糖尿病可损害周围神经和中枢神经系统,是老年人认知功能障碍的危险因素.老年糖尿病认知功能障碍发生机制复杂,目前认为主要与高胰岛素血症和(或)胰岛素缺乏、血糖控制水平、糖基化产物、炎症介质、下丘脑-垂体-肾上腺轴功能失调、血-脑脊液屏障功能障碍等因素密切相关.良好的综合性代谢控制有助于预防老年糖尿病患者认知功能障碍及其进展.
당뇨병가손해주위신경화중추신경계통,시노년인인지공능장애적위험인소.노년당뇨병인지공능장애발생궤제복잡,목전인위주요여고이도소혈증화(혹)이도소결핍、혈당공제수평、당기화산물、염증개질、하구뇌-수체-신상선축공능실조、혈-뇌척액병장공능장애등인소밀절상관.량호적종합성대사공제유조우예방노년당뇨병환자인지공능장애급기진전.
Diabetes could damage the peripheral and central nervous system,and was the risk factor of cognitive impairment in the elderly.The pathogenesis of cognitive dysfunction caused by diabetes was complex.At present,hyperinsulinemia and/or insulin deficiency,glycemic control,glycation end-products,inflammatorv mediators,hypothalamic-pituitary-adrenal axis dysfunction,blood-brain barrier dysfunction and other factors were considered to be the major causes of cognitive impairment in elderly patients with diabetes.Good metabolic control may help prevent its occurrence and/or progression.