CAJ | 학술논문

目的建立SD大鼠孕期不伴有贫血的铁缺乏和轻度缺铁性贫血(IDA)的模型,并观察母体甲状腺功能的动态变化.方法检测血红蛋白、血清铁、肝铁、甲状腺激素水平和甲状腺过氧化物酶(TPO)活性以及显微镜下甲状腺结构.结果孕期轻度IDA和不伴有贫血的铁缺乏可以导致母鼠的TPO活性明显降低和母鼠低甲状腺素血症.铁缺乏导致甲状腺滤泡腔缩小,但没有破坏滤泡腔结构.结论孕期铁缺乏可能是孕期母体低甲状腺素血症的病因之一,而孕期铁缺乏导致的低甲状腺素血症可能是孕期铁缺乏导致后代脑发育障碍的机制之一.
목적 건립SD대서잉기불반유빈혈적철결핍화경도결철성빈혈(IDA)적모형,병관찰모체갑상선공능적동태변화.방법 검측혈홍단백、혈청철、간철、갑상선격소수평화갑상선과양화물매(TPO)활성이급현미경하갑상선결구.결과 잉기경도IDA화불반유빈혈적철결핍가이도치모서적TPO활성명현강저화모서저갑상선소혈증.철결핍도치갑상선려포강축소,단몰유파배려포강결구.결론 잉기철결핍가능시잉기모체저갑상선소혈증적병인지일,이잉기철결핍도치적저갑상선소혈증가능시잉기철결핍도치후대뇌발육장애적궤제지일.
Objective To establish animal models of iron deficiency without anemia and mild iron deficiency anemia (IDA) in rat during pregnancy and to explore the dynamic changes in maternal thyroid function.Methods Hemoglobin,serum iron,liver iron,thyroid hormone,and thyroid peroxidase (TPO) activity were measured,and thyroid structure was examined under microscope.Results Both mild IDA and iron deficiency without anemia resulted in maternal hypothyroxinemia from mid-gestation to the end of pregnancy.TPO activity was significantly decreased even before reduction of liver iron concentrations in iron deficiency groups.Iron deficiency resulted in shrinkage of follicular cavities,but did not result in destruction of follicular structure.Conclusions Iron deficiency may be one of the etiological factors of maternal hypothyroxinemia,which could be one of the mechanisms of brain dysfunction caused by maternal iron deficiency.