中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2010年
3期
220-222
,共3页
低钾性周期性麻痹%低钾血症%因果律
低鉀性週期性痳痺%低鉀血癥%因果律
저갑성주기성마비%저갑혈증%인과률
Hypokalemic periodic paralysis%Hypokalamia%Causality
目的 分析影响低钾型周期性瘫痪(HOPP)患者肢体瘫痪程度的相关因素.方法 回顾分析80例HOPP患者的病历.应用单因素及多元回归分析探讨影响肢体瘫痪程度的相关因素.结果 单因素分析显示:伴发胸闷、心悸、恶心、呕吐以及肌肉酸痛患者,血清镁离子水平降低、血清钾离子水平极低、血清肌酸激酶水平升高以及伴心电图异常的患者瘫痪程度明显严重.多元回归分析发现血清镁<0.8 mmol/L(OR 8.3, 95% CI 1.0～68.4, P<0.05)、血清肌酸激酶>200 U/L(OR 1.1,95% CI 1.0～1.1, P<0.01)及血清钾1.5～1.8 mmol/L(OR1.3,95% CI 1.1～16.0, P<0.01)是影响HOPP患者瘫痪程度的独立危险因素.结论 血清镁离子水平降低、血清肌酸激酶水平升高及血清钾离子水平极低是HOPP患者重度肢体瘫痪的独立危险因素.
目的 分析影響低鉀型週期性癱瘓(HOPP)患者肢體癱瘓程度的相關因素.方法 迴顧分析80例HOPP患者的病歷.應用單因素及多元迴歸分析探討影響肢體癱瘓程度的相關因素.結果 單因素分析顯示:伴髮胸悶、心悸、噁心、嘔吐以及肌肉痠痛患者,血清鎂離子水平降低、血清鉀離子水平極低、血清肌痠激酶水平升高以及伴心電圖異常的患者癱瘓程度明顯嚴重.多元迴歸分析髮現血清鎂<0.8 mmol/L(OR 8.3, 95% CI 1.0～68.4, P<0.05)、血清肌痠激酶>200 U/L(OR 1.1,95% CI 1.0～1.1, P<0.01)及血清鉀1.5～1.8 mmol/L(OR1.3,95% CI 1.1～16.0, P<0.01)是影響HOPP患者癱瘓程度的獨立危險因素.結論 血清鎂離子水平降低、血清肌痠激酶水平升高及血清鉀離子水平極低是HOPP患者重度肢體癱瘓的獨立危險因素.
목적 분석영향저갑형주기성탄탄(HOPP)환자지체탄탄정도적상관인소.방법 회고분석80례HOPP환자적병력.응용단인소급다원회귀분석탐토영향지체탄탄정도적상관인소.결과 단인소분석현시:반발흉민、심계、악심、구토이급기육산통환자,혈청미리자수평강저、혈청갑리자수평겁저、혈청기산격매수평승고이급반심전도이상적환자탄탄정도명현엄중.다원회귀분석발현혈청미<0.8 mmol/L(OR 8.3, 95% CI 1.0～68.4, P<0.05)、혈청기산격매>200 U/L(OR 1.1,95% CI 1.0～1.1, P<0.01)급혈청갑1.5～1.8 mmol/L(OR1.3,95% CI 1.1～16.0, P<0.01)시영향HOPP환자탄탄정도적독립위험인소.결론 혈청미리자수평강저、혈청기산격매수평승고급혈청갑리자수평겁저시HOPP환자중도지체탄탄적독립위험인소.
Objectives To analyze the independent factors for the severity of paralysis in the patients with hypokalemie periodic paralysis (HOPP). Methods Eishty patients admitted with HOPP were reviewed. Using univariate analysis and multivariate analysis. the independent factors for the severity of paralysis were revealed. Results A total of 76 cases were male and 4 female with a mean age of (26.3±4.5) years. Univariate analysis showed that patients with low serum magnesium level, low serum potassium level, high serum creatine kinase level, changes of electrocardiogram, chest distress and palpitation, nausea and vomiting as well as muscular soreness had more severe paralysis, while multivariate analysis revealed that serum magnesium <0.8 mmol/L (OR 8.3,95% CI 1.0-68.4, P<0.05), serum potassium 1.5-1.8mmol/L (OR 1.3.95% CI 1.1-16.0, P<0.01) and serum creatine kinase >200 U/L (OR1.1.95% CI 1.0-1.1, P<0.01) were the independent factors for the severity of paralysis. Conclusion Low serum magnesium level. low serum potassium level and high serum creatine kinase level are the independent risk factors for more severe paralysis in patients with HOPP.
