中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2013年
4期
309-312
,共4页
黄秋霞%朱鹏立%黄峰%林帆%郜忠海%陈发林%黄建刚
黃鞦霞%硃鵬立%黃峰%林帆%郜忠海%陳髮林%黃建剛
황추하%주붕립%황봉%림범%고충해%진발림%황건강
高血压%蛋白尿%视网膜中央动脉直径
高血壓%蛋白尿%視網膜中央動脈直徑
고혈압%단백뇨%시망막중앙동맥직경
Hypertension%Proteinuria%Retinal artery
目的 探讨福建省沿海地区高血压人群尿微量白蛋白肌酐比值(UACR)与眼底血管直径的相关性.方法 免散瞳眼底照相测得视网膜中央动/静脉直径(CRAE/CRVE),并测定尿微量白蛋白及尿肌酐.结果 (1)正常对照组、高血压非蛋白尿组、高血压蛋白尿组间CRAE差异有统计学意义[(135.68±10.10) μm、(129.79±10.48) μm、(125.29±11.17) μm,P＜0.01];(2)CRAE与UACR呈负相关(r=-0.29,P＜0.01)；(3)线性回归分析显示高血压人群UACR与CRAE相关(β=-5.0,P＜0.01)；(4) logistic回归分析显示收缩压为CRAE异常的危险因素(β=1.08,P=0.02),正常对照、高血压非蛋白尿、高血压伴蛋白尿三者CRAE异常率依次增高(P＜0.01).结论 视网膜中央动脉直径的缩小与高血压肾损害存在相关性,UACR和CRAE可共同评估高血压微小血管病变,成为评价高血压靶器官损害的指标.
目的 探討福建省沿海地區高血壓人群尿微量白蛋白肌酐比值(UACR)與眼底血管直徑的相關性.方法 免散瞳眼底照相測得視網膜中央動/靜脈直徑(CRAE/CRVE),併測定尿微量白蛋白及尿肌酐.結果 (1)正常對照組、高血壓非蛋白尿組、高血壓蛋白尿組間CRAE差異有統計學意義[(135.68±10.10) μm、(129.79±10.48) μm、(125.29±11.17) μm,P＜0.01];(2)CRAE與UACR呈負相關(r=-0.29,P＜0.01)；(3)線性迴歸分析顯示高血壓人群UACR與CRAE相關(β=-5.0,P＜0.01)；(4) logistic迴歸分析顯示收縮壓為CRAE異常的危險因素(β=1.08,P=0.02),正常對照、高血壓非蛋白尿、高血壓伴蛋白尿三者CRAE異常率依次增高(P＜0.01).結論 視網膜中央動脈直徑的縮小與高血壓腎損害存在相關性,UACR和CRAE可共同評估高血壓微小血管病變,成為評價高血壓靶器官損害的指標.
목적 탐토복건성연해지구고혈압인군뇨미량백단백기항비치(UACR)여안저혈관직경적상관성.방법 면산동안저조상측득시망막중앙동/정맥직경(CRAE/CRVE),병측정뇨미량백단백급뇨기항.결과 (1)정상대조조、고혈압비단백뇨조、고혈압단백뇨조간CRAE차이유통계학의의[(135.68±10.10) μm、(129.79±10.48) μm、(125.29±11.17) μm,P＜0.01];(2)CRAE여UACR정부상관(r=-0.29,P＜0.01)；(3)선성회귀분석현시고혈압인군UACR여CRAE상관(β=-5.0,P＜0.01)；(4) logistic회귀분석현시수축압위CRAE이상적위험인소(β=1.08,P=0.02),정상대조、고혈압비단백뇨、고혈압반단백뇨삼자CRAE이상솔의차증고(P＜0.01).결론 시망막중앙동맥직경적축소여고혈압신손해존재상관성,UACR화CRAE가공동평고고혈압미소혈관병변,성위평개고혈압파기관손해적지표.
Objective To investigate the association of urinary albumin-to-creatinine ratio (UACR) and the diameter of retinal vessel in population with essential hypertension in Fujian coastal area.Methods Central retinal artery and vein equivalents (CRAE and CRVE) were measured from the avoiding mydriatic digitized photographs and semi-automatic fundus analysis software,as well as albumin and urine creatinine.Results There were significant differences in CRAE levels among the normal control group,normoalbuminuria with essential hypertension group and microalbuminuria with essential hypertension group [(135.68 ± 10.10) μm,(129.79 ± 10.48) μm,(125.29 ± 11.17) μm,all P values ＜0.01].The CRAE levels were significantly negative correlated with UACR (r =-0.29,P ＜ 0.01).Linear regression analysis showed CRAE was associated with UACR in the patients with hypertension(β =-5.0,P ＜ 0.01).Logistic regression analysis showed,systolic blood pressure (β =1.08,P =0.02) was risk factor for CRAE abnormality.The CRAE abnormality was increased in turn in the normal control group,normoalbuminuria with the essential hypertension group and microalbuminuria with essential hypertension group (P ＜ 0.01).Conclusion The reduction of central retinal artery diameter are associated with the hypertensive renal damage.UACR and CRAE could be used to evaluate the microvascular lesions and be used as an indicator to assess the target organs damage in essential hypertension patients.
