中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2013年
5期
387-389
,共3页
江颖%皮红英%闫雅凤%侯惠如%刘敏燕%方福生%裴育%李春霖
江穎%皮紅英%閆雅鳳%侯惠如%劉敏燕%方福生%裴育%李春霖
강영%피홍영%염아봉%후혜여%류민연%방복생%배육%리춘림
骨质疏松%病人依从%男性%阿仑膦酸钠
骨質疏鬆%病人依從%男性%阿崙膦痠鈉
골질소송%병인의종%남성%아륜련산납
Osteoporosis%Patient compliance%Male%Alendronate
目的 调查老年男性骨质疏松症患者口服阿仑膦酸钠的依从性,探讨影响服药依从性的相关因素.方法 入选2011年1-6月在解放军总医院门诊确诊骨质疏松症并开始口服阿仑膦酸钠治疗的老年男性患者145例,调查其服该药1年的依从性,根据药物占有率(MPR)分为依从性好组(MPR ≥80％)和差组(MPR＜ 80％),比较两组差异,分析影响依从性的因素.结果 随访到139例患者,其中依从性好者32例(23.02％),依从性差者107例(76.98％)；对筛选出的影响服药依从性的因素进行logistic回归分析,结果显示,骨痛(OR值0.69,P=0.043)、无人提醒用药(OR值1.37,P =0.025)、担心药物副作用(OR值1.49,P=0.018)、服药种类＞7种(OR值1.30,P=0.036)、不清楚远期疗效(OR值1.39,P=0.021)为影响服药依从性的因素.结论 老年男性骨质疏松症患者口服阿仑膦酸钠治疗的依从性差；降低服药依从性的因素有:无人提醒服药、担心药物副作用、服药种类＞7种和不清楚远期疗效；骨痛可提高患者服药依从性.
目的 調查老年男性骨質疏鬆癥患者口服阿崙膦痠鈉的依從性,探討影響服藥依從性的相關因素.方法 入選2011年1-6月在解放軍總醫院門診確診骨質疏鬆癥併開始口服阿崙膦痠鈉治療的老年男性患者145例,調查其服該藥1年的依從性,根據藥物佔有率(MPR)分為依從性好組(MPR ≥80％)和差組(MPR＜ 80％),比較兩組差異,分析影響依從性的因素.結果 隨訪到139例患者,其中依從性好者32例(23.02％),依從性差者107例(76.98％)；對篩選齣的影響服藥依從性的因素進行logistic迴歸分析,結果顯示,骨痛(OR值0.69,P=0.043)、無人提醒用藥(OR值1.37,P =0.025)、擔心藥物副作用(OR值1.49,P=0.018)、服藥種類＞7種(OR值1.30,P=0.036)、不清楚遠期療效(OR值1.39,P=0.021)為影響服藥依從性的因素.結論 老年男性骨質疏鬆癥患者口服阿崙膦痠鈉治療的依從性差；降低服藥依從性的因素有:無人提醒服藥、擔心藥物副作用、服藥種類＞7種和不清楚遠期療效；骨痛可提高患者服藥依從性.
목적 조사노년남성골질소송증환자구복아륜련산납적의종성,탐토영향복약의종성적상관인소.방법 입선2011년1-6월재해방군총의원문진학진골질소송증병개시구복아륜련산납치료적노년남성환자145례,조사기복해약1년적의종성,근거약물점유솔(MPR)분위의종성호조(MPR ≥80％)화차조(MPR＜ 80％),비교량조차이,분석영향의종성적인소.결과 수방도139례환자,기중의종성호자32례(23.02％),의종성차자107례(76.98％)；대사선출적영향복약의종성적인소진행logistic회귀분석,결과현시,골통(OR치0.69,P=0.043)、무인제성용약(OR치1.37,P =0.025)、담심약물부작용(OR치1.49,P=0.018)、복약충류＞7충(OR치1.30,P=0.036)、불청초원기료효(OR치1.39,P=0.021)위영향복약의종성적인소.결론 노년남성골질소송증환자구복아륜련산납치료적의종성차；강저복약의종성적인소유:무인제성복약、담심약물부작용、복약충류＞7충화불청초원기료효；골통가제고환자복약의종성.
Objective To explore the compliance in elderly male with osteoporosis treated with oral alendronate and analyze the factors which affect the therapeutic compliance.Methods A total of 145elderly male patients diagnosed with osteoporosis who had been initiated the treatment of oral alendronate in our clinic during January to June in 2011 were enrolled in the study.The medication compliance of one year was investigated.According to the different medication possession ratio (MPR),MPR ≥ 80％ was considered as adherent and MPR ＜ 80％ was considered as non-adherent.The difference in the two groups was compared and the factors which affect the therapeutic compliance were analyzed.Results A total of 139 patients had been followed up with 32 adherent cases (23.02％) and 107 non-adherent cases (76.98％).Logistic regression analysis showed the factors which affected the therapeutic compliance as the following:ostealgia (OR =0.69,P =0.043),no-reminder (OR =1.37,P =0.025),concern about drug related side effect (OR =1.49,P =0.018),more than 7 kinds of drugs (OR =1.30,P =0.036) and uncertain long-term effect (OR =1.39,P =0.021).Conclusions Compliance of oral alendronate to treat osteoporosis in elderly male patients is poor.Ostealgia can promote the drug compliance.The factors which could decrease the drug compliance are no-reminder,concern about drug related side effect,more than 7 kinds of drugs and uncertain long-term efficacy.
