中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2014年
1期
9-12
,共4页
顾云娟%崔世维%于浩泳%胡承%陆俊茜%马晓静%包玉倩%贾伟平
顧雲娟%崔世維%于浩泳%鬍承%陸俊茜%馬曉靜%包玉倩%賈偉平
고운연%최세유%우호영%호승%륙준천%마효정%포옥천%가위평
肥胖症%膳食,低碳水化合物%心血管疾病%危险因素
肥胖癥%膳食,低碳水化閤物%心血管疾病%危險因素
비반증%선식,저탄수화합물%심혈관질병%위험인소
Obesity%Diet,carbohydrate-restricted%Cardiovascular disease%Risk factor
目的 观察极低碳水化合物饮食(VLCD)治疗对单纯性肥胖患者心血管危险因素的影响.方法 观察35例肥胖患者经VLCD治疗8周后,体重、腰围及血压改善的同时,空腹血糖(FPG)、空腹胰岛素(FIns)、血脂谱、尿微量白蛋白/肌酐(UACR)、C反应蛋白(CRP)、TNFα、脂联素(adiponectin)等心血管危险因素的改变.另采集35例健康志愿者作为基线对照组.结果 基线时肥胖组较正常对照组有更显著的心血管危险因素(P值均＜0.05).试验结束时肥胖患者的体重与腰围分别减少了(8.5 ±0.7)kg与(6.6±1.1)cm(P值均＜0.01);收缩压、舒张压、FIns、TC、TG等指标均较前显著降低(P值均＜0.05);FPG、LDL-C及HDL-C等的改变无统计学意义;UACR、CRP、TNFα分别减少了(1.86 ±0.86) μg/mg、(1.15 ±0.45) mg/L及(0.94 ±0.21)ng/L(P值均＜0.05);脂联素水平增加了(2.12 ±0.59)mg/L(P ＜0.01).结论 8周的VLCD治疗肥胖症可有效减重并显著改善多种心血管危险因素.
目的 觀察極低碳水化閤物飲食(VLCD)治療對單純性肥胖患者心血管危險因素的影響.方法 觀察35例肥胖患者經VLCD治療8週後,體重、腰圍及血壓改善的同時,空腹血糖(FPG)、空腹胰島素(FIns)、血脂譜、尿微量白蛋白/肌酐(UACR)、C反應蛋白(CRP)、TNFα、脂聯素(adiponectin)等心血管危險因素的改變.另採集35例健康誌願者作為基線對照組.結果 基線時肥胖組較正常對照組有更顯著的心血管危險因素(P值均＜0.05).試驗結束時肥胖患者的體重與腰圍分彆減少瞭(8.5 ±0.7)kg與(6.6±1.1)cm(P值均＜0.01);收縮壓、舒張壓、FIns、TC、TG等指標均較前顯著降低(P值均＜0.05);FPG、LDL-C及HDL-C等的改變無統計學意義;UACR、CRP、TNFα分彆減少瞭(1.86 ±0.86) μg/mg、(1.15 ±0.45) mg/L及(0.94 ±0.21)ng/L(P值均＜0.05);脂聯素水平增加瞭(2.12 ±0.59)mg/L(P ＜0.01).結論 8週的VLCD治療肥胖癥可有效減重併顯著改善多種心血管危險因素.
목적 관찰겁저탄수화합물음식(VLCD)치료대단순성비반환자심혈관위험인소적영향.방법 관찰35례비반환자경VLCD치료8주후,체중、요위급혈압개선적동시,공복혈당(FPG)、공복이도소(FIns)、혈지보、뇨미량백단백/기항(UACR)、C반응단백(CRP)、TNFα、지련소(adiponectin)등심혈관위험인소적개변.령채집35례건강지원자작위기선대조조.결과 기선시비반조교정상대조조유경현저적심혈관위험인소(P치균＜0.05).시험결속시비반환자적체중여요위분별감소료(8.5 ±0.7)kg여(6.6±1.1)cm(P치균＜0.01);수축압、서장압、FIns、TC、TG등지표균교전현저강저(P치균＜0.05);FPG、LDL-C급HDL-C등적개변무통계학의의;UACR、CRP、TNFα분별감소료(1.86 ±0.86) μg/mg、(1.15 ±0.45) mg/L급(0.94 ±0.21)ng/L(P치균＜0.05);지련소수평증가료(2.12 ±0.59)mg/L(P ＜0.01).결론 8주적VLCD치료비반증가유효감중병현저개선다충심혈관위험인소.
Objective To investigate the effects of a very low carbohydrate diet (VLCD) on improving cardiovascular risk factors in obese individuals.Methods A 8-week VLCD was given to 35 healthy obese subjects and the control group was consisted of 35 healthy volunteers.Multi-cardiovascular risk factors were investigated,including weight,waist circumference,BMI,blood pressure,fasting plasma glucose (FPG),fasting insulin (FIns),lipid profiles,urinary albumin-creatinine ratio (UACR),C-reactive protein(CRP),TNFα and adiponectin.Results At the baseline of the study,compared with the healthy control group,all the cardiovascular risk factors were significantly more deteriorated in the obese subjects (all P values ＜ 0.05).At the end of the study,the obese subjects showed significant decrease in their mean weight and waist circumference [(8.5 ± 0.7) kg and (6.6 ± 1.1) cm,respectively; all P values ＜ 0.01].Significant decrease was also found in the levels of systolic blood pressure (SBP),diastolic blood pressure (DBP),FIns,TC and TG (all P values ＜ 0.05),while no significant change of FPG,HDL-C and LDL-C.The levels of UACR,CRP and TNFα were all significantly decreased [(1.86 ± 0.86) μg/mg,(1.15 ± 0.45) mg/L and (0.94 ± 0.21) ng/L,respectively; all P values ＜ 0.05],while the level of adiponectin was significantly increased [(2.12 ± 0.59) mg/L,P ＜ 0.01].Conclusion VLCD is an effective intervention in obese subjects which could improve the cardiovascular risk factors by the modest weight loss.
