CAJ | 학술논문

目的探讨血清尿酸(UA)水平的变化与腹型肥胖及代谢综合征(MS)的相关性.方法 875例40 ～ 65岁杭州社区居民进入研究,其中男350例,女525例.对所有研究对象均进行问卷调查、体检和血清学检查,并进行腹部MRI扫描,测量腹内脂肪面积和皮下脂肪面积,分析UA水平与腹型肥胖和MS的相关性,并确定UA作为MS诊断的参考指标的最佳界值.结果该人群中随着UA水平增加,腹型肥胖(男性OR =4.35,95％ CI 1.91 ～9.90;女性OR=5.44,95％CI2.41 ～ 12.31)和MS(男性OR=4.47,95％ CI2.08 ～9.62;女性OR=11.62,95％ CI 3.43 ～ 39.37)风险增加.多项logistic回归分析显示,UA是TG升高(男性OR =2.23,95％ CI 1.02 ～4.87;女性OR=3.04,95％ CI1.49 ～6.23)、女性腹型肥胖(OR=3.23,95％ CI 1.32～7.91)和血压升高(OR=2.35,95％ CI1.37～4.05)的独立危险因素.在女性中,根据腹内脂肪面积建立多元线性回归模型,UA的最佳切点为244.0 μmol/L,而通过受试者ROC曲线获得MS诊断的最佳界值为258.8 μmol/L.结论在我国中年人群中,UA与腹型肥胖和MS密切相关.UA水平升高是女性腹型肥胖和MS的独立危险因素.
목적 탐토혈청뇨산(UA)수평적변화여복형비반급대사종합정(MS)적상관성.방법 875례40 ～ 65세항주사구거민진입연구,기중남350례,녀525례.대소유연구대상균진행문권조사、체검화혈청학검사,병진행복부MRI소묘,측량복내지방면적화피하지방면적,분석UA수평여복형비반화MS적상관성,병학정UA작위MS진단적삼고지표적최가계치.결과 해인군중수착UA수평증가,복형비반(남성OR =4.35,95％ CI 1.91 ～9.90;녀성OR=5.44,95％CI2.41 ～ 12.31)화MS(남성OR=4.47,95％ CI2.08 ～9.62;녀성OR=11.62,95％ CI 3.43 ～ 39.37)풍험증가.다항logistic회귀분석현시,UA시TG승고(남성OR =2.23,95％ CI 1.02 ～4.87;녀성OR=3.04,95％ CI1.49 ～6.23)、녀성복형비반(OR=3.23,95％ CI 1.32～7.91)화혈압승고(OR=2.35,95％ CI1.37～4.05)적독립위험인소.재녀성중,근거복내지방면적건립다원선성회귀모형,UA적최가절점위244.0 μmol/L,이통과수시자ROC곡선획득MS진단적최가계치위258.8 μmol/L.결론 재아국중년인군중,UA여복형비반화MS밀절상관.UA수평승고시녀성복형비반화MS적독립위험인소.
Objective To investigate the relationship between serum uric acid (UA) level and abdominal obesity or metabolic syndrome (MS).Methods A total of 875 subjects,with 350 males and 525 females,aged 40-65 years old,were enrolled in this study.The clinical and biochemical data were collected and MRI was used to assess the visceral and subcutaneous adipose tissues.The relationships between UA level and abdominal obesity or MS were analyzed,and the cut-off values of UA for abdominal obesity and MS were determined.Results Raised risks of abdominal obesity (OR =4.35,95％ CI 1.91-9.90 in males; OR =5.44,95％ CI 2.41-12.31 in females) and MS (OR =4.47,95 ％ CI 2.08-9.62 in males; OR =11.62,95％ CI 3.43-39.37 in females) were observed with the increase of UA level.The multiple logistic regression analysis showed that UA was an independent risk factor for hypertriglyceridemia (OR =2.23,95％ CI 1.02-4.87 in males ; OR =3.04,95％ CI 1.49-6.23 in females) in all subjects and for abdominal obesity(OR =3.23,95％ CI 1.32-7.91) and hypertension (OR =2.35,95％ CI 1.37-4.05)in the females.Among the females,the regression line analyzed by simple correlation indicated that the UA level of 244.0 μmol/L was corresponded to the visceral adipose tissue area of 80 cm2.The optimal cut-off point of UA for the diagnosis of MS was 258.8 μmol/L determined by the receiver operating characteristic curve.Conclusions The level of UA is closely correlated with abdominal obesity and MS in the middleaged Chinese.The elevated UA level is an independent risk factor for abdominal obesity and MS in the female.