CAJ | 학술논문

目的探讨散发性肌萎缩侧索硬化(sALS)患者血清肌酐(SCr)水平及其与临床指标的关系.方法测定sALS、多系统萎缩(MSA)和紧张型头痛(TTH)各80例患者的SCr水平,分析sALS患者SCr水平与肌萎缩侧索硬化功能评分(ALSFRS-R)、用力肺活量(FVC)占预计值百分比、起病部位、病程和疾病进展速率之间的关系.结果 sALS组SCr水平低于MSA组和TTH组,差异有统计学意义[(60.86±16.80)μmol/L比(70.05±12.79) μmol/L和(66.97±14.14)μmol/L,P＜0.01];MSA组与TTH组SCr水平的差异无统计学意义(P =0.141).sALS患者SCr水平与ALSFRS-R呈正相关(r =0.315,P=0.005),而与FVC占预计值百分比、起病部位、病程和疾病进展速率无明显相关性(P值均＞0.05).结论 SCr水平是sALS的一项重要生化指标,对监测疾病进展可能具有重要的作用.
목적 탐토산발성기위축측색경화(sALS)환자혈청기항(SCr)수평급기여림상지표적관계.방법 측정sALS、다계통위축(MSA)화긴장형두통(TTH)각80례환자적SCr수평,분석sALS환자SCr수평여기위축측색경화공능평분(ALSFRS-R)、용력폐활량(FVC)점예계치백분비、기병부위、병정화질병진전속솔지간적관계.결과 sALS조SCr수평저우MSA조화TTH조,차이유통계학의의[(60.86±16.80)μmol/L비(70.05±12.79) μmol/L화(66.97±14.14)μmol/L,P＜0.01];MSA조여TTH조SCr수평적차이무통계학의의(P =0.141).sALS환자SCr수평여ALSFRS-R정정상관(r =0.315,P=0.005),이여FVC점예계치백분비、기병부위、병정화질병진전속솔무명현상관성(P치균＞0.05).결론 SCr수평시sALS적일항중요생화지표,대감측질병진전가능구유중요적작용.
Objective To investigate the serum creatinine (SCr) level in patients with sporadic amyotrophic lateral sclerosis (sALS) and to explore the relationship between the SCr level and the clinical characteristics.Methods A total of 80 patients with sALS,80 patients with multiple system atrophy (MSA) and 80 patients with tension-type headache (TTH) were enrolled in the study.The SCr levels were compared among the three groups.The association between the SCr level and the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R),the forced vital capacity (FVC) percentage of predicted (FVC％ pred),the site of symptom onset,the duration of disease and the rate of disease progression was evaluated in the sALS group.Results The SCr level was significantly decreased in the sALS group than the other two groups [(60.86 ± 16.80) μmol/L vs (70.05 ± 12.79) μmol/L and (66.97-± 14.14) μmol/L,P ＜ 0.01].In the sALS group,the SCr level was positively correlated with the ALSFRS-R (r =0.315,P =0.005),while no correlation was found between the SCr level and the FVC％ pred,the site of symptom onset,the duration of disease and the rate of disease progression (all P ＞ 0.05).Conclusion The SCr level is an important biochemical index in the patients with sALS and might play an important role in monitoring the disease progression.