中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2014年
4期
286-289
,共4页
闫慧娴%谷伟军%吕朝晖%杨国庆%巴建明%王先令%欧阳金芝%郭清华%杜锦
閆慧嫻%穀偉軍%呂朝暉%楊國慶%巴建明%王先令%歐暘金芝%郭清華%杜錦
염혜한%곡위군%려조휘%양국경%파건명%왕선령%구양금지%곽청화%두금
甲状腺结节%甲状腺肿瘤%性别特征
甲狀腺結節%甲狀腺腫瘤%性彆特徵
갑상선결절%갑상선종류%성별특정
Thyroid nodule%Thyroid neoplasms%Gender identity
目的 比较分析不同性别分化型甲状腺癌(DTC)患者的临床特征.方法 回顾性分析2001年10月至2011年5月在解放军总医院行甲状腺切除术并且术后经病理证实为DTC患者的临床资料,按性别分组对其临床特征进行比较分析.结果 (1)共纳入1 756例DTC患者,以女性患者更多见,男女之比为1∶2.32;男女DTC患者高峰年龄段均出现在35～45岁.男性单结节中DTC所占比例显著高于多结节者(36.42％比28.90％,P＜0.01),女性单结节与多结节中DTC所占比例差异无统计学意义(33.60％比31.77％,P＞0.05).(2)超声检查显示,发生微钙化的甲状腺结节中,女性患者DTC的比例高于男性患者(69.26％比62.62％,P＜0.05);边界不清晰的甲状腺结节中,女性组DTC的比例低于男性组(57.79％比72.01％,P ＜0.01).(3)男性组DTC患者肿瘤直径(1.8±1.5)cm大于女性组(1.6±1.3)cm(P ＜0.01),肿瘤分期为Ⅲ/Ⅳ期的比例高于女性组(21.74％比14.51％,P＜0.01),颈部淋巴结转移发生率更高(33.27％比23.80％,P＜0.01),甲状腺外侵袭发生率更高(10.59％比7.17％,P ＜0.01).结论 DTC患者的临床特征存在性别差异.
目的 比較分析不同性彆分化型甲狀腺癌(DTC)患者的臨床特徵.方法 迴顧性分析2001年10月至2011年5月在解放軍總醫院行甲狀腺切除術併且術後經病理證實為DTC患者的臨床資料,按性彆分組對其臨床特徵進行比較分析.結果 (1)共納入1 756例DTC患者,以女性患者更多見,男女之比為1∶2.32;男女DTC患者高峰年齡段均齣現在35～45歲.男性單結節中DTC所佔比例顯著高于多結節者(36.42％比28.90％,P＜0.01),女性單結節與多結節中DTC所佔比例差異無統計學意義(33.60％比31.77％,P＞0.05).(2)超聲檢查顯示,髮生微鈣化的甲狀腺結節中,女性患者DTC的比例高于男性患者(69.26％比62.62％,P＜0.05);邊界不清晰的甲狀腺結節中,女性組DTC的比例低于男性組(57.79％比72.01％,P ＜0.01).(3)男性組DTC患者腫瘤直徑(1.8±1.5)cm大于女性組(1.6±1.3)cm(P ＜0.01),腫瘤分期為Ⅲ/Ⅳ期的比例高于女性組(21.74％比14.51％,P＜0.01),頸部淋巴結轉移髮生率更高(33.27％比23.80％,P＜0.01),甲狀腺外侵襲髮生率更高(10.59％比7.17％,P ＜0.01).結論 DTC患者的臨床特徵存在性彆差異.
목적 비교분석불동성별분화형갑상선암(DTC)환자적림상특정.방법 회고성분석2001년10월지2011년5월재해방군총의원행갑상선절제술병차술후경병리증실위DTC환자적림상자료,안성별분조대기림상특정진행비교분석.결과 (1)공납입1 756례DTC환자,이녀성환자경다견,남녀지비위1∶2.32;남녀DTC환자고봉년령단균출현재35～45세.남성단결절중DTC소점비례현저고우다결절자(36.42％비28.90％,P＜0.01),녀성단결절여다결절중DTC소점비례차이무통계학의의(33.60％비31.77％,P＞0.05).(2)초성검사현시,발생미개화적갑상선결절중,녀성환자DTC적비례고우남성환자(69.26％비62.62％,P＜0.05);변계불청석적갑상선결절중,녀성조DTC적비례저우남성조(57.79％비72.01％,P ＜0.01).(3)남성조DTC환자종류직경(1.8±1.5)cm대우녀성조(1.6±1.3)cm(P ＜0.01),종류분기위Ⅲ/Ⅳ기적비례고우녀성조(21.74％비14.51％,P＜0.01),경부림파결전이발생솔경고(33.27％비23.80％,P＜0.01),갑상선외침습발생솔경고(10.59％비7.17％,P ＜0.01).결론 DTC환자적림상특정존재성별차이.
Objective To investigate the clinical characteristics of patients with different gender who diagnosed as differentiated thyroid cancers(DTC).Methods A cohort of patients with DTC underwent surgery in Chinese PLA General Hospital from October 2001 to may 2011 was retrospectively studied.Results (1) A total of 1 756 patients with DTC were enrolled in the study and a marked female preponderance was found with the female/male ratio of 2.32∶ 1.The peak incidence was 35-45 years old in both genders.Higher prevalence of DTC was observed in the male patients with a single nodule than in the males with multinodulars (36.42％ vs 28.90％,P ＜ 0.01),while no statistical difference was found in the female patients(33.60％ vs 31.77％,P ＞ 0.05).(2) Ultrasound examination revealed that,the female DTC patients with microcalcification thyroid nodules were more than the male patients (69.26％ vs 62.62％,P ＜0.05),while less in female patients with undefined boundary thyroid nodules (57.79％ vs 72.01％,P ＜ 0.01).The tumor size was shown to be smaller in the women than in the men [(1.6 ± 1.3) cm vs (1.8 ± 1.5) cm,P ＜ 0.01].(3) Higher rates of Ⅲ/Ⅳ TNM Stage,lymph node metastasis and extrathyroidal invasion were found in the men than in the women (21.74％ vs 14.51％,P ＜0.01,33.27％ vs 23.80％,P ＜0.01 and 10.59％ vs 7.17％,P ＜ 0.01).Conclusion There is significant gender-related difference of clinical characteristics in the patients with DTC.
