CAJ | 학술논문

目的评价高血压与年龄增长叠加对左心房大小与功能的影响.方法使用738例社区心血管疾病高危人群横断面资料,按年龄分组(41～ 59岁、60 ～ 69岁、≥70岁)并划分高血压与非高血压亚组.测量左心房容积指数,并使用二维斑点追踪超声心动图技术测量舒张晚期(心房收缩期)左心房应变(Sa)、舒张早期应变(Se)、总应变(Stot=Sa+Se),及舒张晚期应变率(SRa)、收缩期应变率(SRs)、舒张早期应变率(SRe),比较各组上述指标.结果左心房容积指数非高血压组各年龄段差异无统计学意义,高血压组随年龄增长而增大;左心房通道功能指标(Se、SRe)两组均随年龄增长降低,但各年龄组高血压组均显著低于非高血压组,测值在41～59岁高血压组与60 ～ 69岁非高血压组接近[Se:(11.0±4.4)％比(11.6±4.7)％,SRe:(1.0±0.4)s-1比(1.0±0.3)s-1]、高血压60 ～ 69岁组与非高血压≥70岁组接近[Se:(10.1±4.0)％比(9.5±5.4)％,SRe:(0.9 ±0.3)s-1比(0.8±0.4)s-].左心房储存功能指标(Stot、SRs)、收缩功能指标(Sa、SRa)高血压组随年龄增长而降低,非高血压组无显著变化.结论单纯年龄增长不导致左心房扩大,高血压与年龄增长叠加造成左心房扩大.高血压加速年龄增长所致左心房时相功能障碍.
목적 평개고혈압여년령증장첩가대좌심방대소여공능적영향.방법 사용738례사구심혈관질병고위인군횡단면자료,안년령분조(41～ 59세、60 ～ 69세、≥70세)병화분고혈압여비고혈압아조.측량좌심방용적지수,병사용이유반점추종초성심동도기술측량서장만기(심방수축기)좌심방응변(Sa)、서장조기응변(Se)、총응변(Stot=Sa+Se),급서장만기응변솔(SRa)、수축기응변솔(SRs)、서장조기응변솔(SRe),비교각조상술지표.결과 좌심방용적지수비고혈압조각년령단차이무통계학의의,고혈압조수년령증장이증대;좌심방통도공능지표(Se、SRe)량조균수년령증장강저,단각년령조고혈압조균현저저우비고혈압조,측치재41～59세고혈압조여60 ～ 69세비고혈압조접근[Se:(11.0±4.4)％비(11.6±4.7)％,SRe:(1.0±0.4)s-1비(1.0±0.3)s-1]、고혈압60 ～ 69세조여비고혈압≥70세조접근[Se:(10.1±4.0)％비(9.5±5.4)％,SRe:(0.9 ±0.3)s-1비(0.8±0.4)s-].좌심방저존공능지표(Stot、SRs)、수축공능지표(Sa、SRa)고혈압조수년령증장이강저,비고혈압조무현저변화.결론 단순년령증장불도치좌심방확대,고혈압여년령증장첩가조성좌심방확대.고혈압가속년령증장소치좌심방시상공능장애.
Objective To assess the effect of combined hypertension (HT) and aging on left atrial (LA) size and phasic function.Methods This evaluation was based on the data from a cross-sectional study including 738 subjects with high risk for cardiovascular disease from an urban community in Beijing.Subjects were divided into 3 groups according to age (41-59,60-69 and ≥70 years) and further into HT and non-HT sub-groups.LA volume index were calculated and LA global longitudinal strain in late diastole (Sa),early diastole (Se),and total strain (Stot =Sa + Se),and strain rate in late diastole (SRa),systole (SRs),and early diastole (SRe) were measured using off-line speckle-tracking echocardiography.Results LA volume index increased significantly in HT groups with aging,whereas no changes could be viewed in non-HT subjects among all age groups.LA conduit index (Se and SRe) decreased with aging in both HT and non-HT subjects with more sever in HT subjects than in non-HT subjects in all age groups.The LA conduit index in 41-59 year-HT,and in 60-69 year-HT subjects were comparable with that in 60-69 year-non-HT subjects [Se (11.0 ±4.4)％ vs (11.6 ±4.7)％,SRe (1.0 ±0.4) s-1 vs (1.0 ±-0.3) s-1],and in ≥70 year-non-HT subjects [Se(10.1 ±4.0)％ vs (9.5 ±5.4)％,SRe (0.9 ±0.3)s-1 vs (0.8 ± 0.4) s-1],respectively.LA reservoir (Stot and SRs) and contraction (Sa and SRa) index also decreased with aging in HT but not in non-HT subjects.Conclusions Aging along does not lead to LA enlargement in subjctes,but it does when combined HT.There is synergistic effect of HT and aging on LA volume and phasic function.