CAJ | 학술논문

目的探讨高血压病患者颈动脉斑块及冠心病与血压变异性的关系.方法选取原发性高血压患者126例,行24h动态血压、颈动脉超声、冠状动脉造影或冠状动脉CT检查.根据颈动脉超声结果分为颈动脉斑块组(64例)和非斑块组(62例),根据冠状动脉造影或冠状动脉CT检查结果分为冠心病组(77例)和非冠心病组(49例),分别比较血压变异系数与颈动脉斑块及冠心病的关系.结果 ①颈动脉斑块组SBP平均值及变异系数与非斑块组的差异有统计学意义[SBP平均值:(145±15) mm Hg比(116±10)mm Hg(1 mm Hg=0.133 kPa),变异系数:(0.09±0.03)比(0.07±0.01),P＜0.05],而组间DBP平均值及变异系数的差异无统计学意义(P＞0.05).②冠心病组SBP变异系数和DBP平均值与非冠心病组的差异有统计学意义[SBP变异系数:(0.09±0.02)比(0.07±0.02),DBP平均值:(68±6)mm Hg比(71±6)mm Hg,P＜0.05],组间SBP平均值及DBP变异系数的差异无统计学意义(P＞0.05).③SBP变异系数与冠心病相关(r=3.719,P=0.025).结论血压变异系数尤其是SBP变异系数是颈动脉斑块及冠心病发病的危险因素.
목적 탐토고혈압병환자경동맥반괴급관심병여혈압변이성적관계.방법 선취원발성고혈압환자126례,행24h동태혈압、경동맥초성、관상동맥조영혹관상동맥CT검사.근거경동맥초성결과분위경동맥반괴조(64례)화비반괴조(62례),근거관상동맥조영혹관상동맥CT검사결과분위관심병조(77례)화비관심병조(49례),분별비교혈압변이계수여경동맥반괴급관심병적관계.결과 ①경동맥반괴조SBP평균치급변이계수여비반괴조적차이유통계학의의[SBP평균치:(145±15) mm Hg비(116±10)mm Hg(1 mm Hg=0.133 kPa),변이계수:(0.09±0.03)비(0.07±0.01),P＜0.05],이조간DBP평균치급변이계수적차이무통계학의의(P＞0.05).②관심병조SBP변이계수화DBP평균치여비관심병조적차이유통계학의의[SBP변이계수:(0.09±0.02)비(0.07±0.02),DBP평균치:(68±6)mm Hg비(71±6)mm Hg,P＜0.05],조간SBP평균치급DBP변이계수적차이무통계학의의(P＞0.05).③SBP변이계수여관심병상관(r=3.719,P=0.025).결론 혈압변이계수우기시SBP변이계수시경동맥반괴급관심병발병적위험인소.
Objective To investigate the association between blood pressure variability and carotid/coronary artery atherosclerosis in hypertension patients.Methods All 126 primary hypertension patients admitted in our hospital from October 2010 to October 2012 were enrolled; results of 24 h ambulatory blood pressure,carotid artery ultrasound and coronary arteriography were recorded and analysed.Results ①24 h ambulatory blood pressure and carotid artery plaque:the average systolic pressure and systolic variation were significantly higher compared with carotid artery atherosclerosis negative group [(145 ± 15)mm Hg vs (116 ± 10)mm Hg (1 mm Hg =0.133 kPa),(0.09 ±0.03) vs (0.07 ±0.01),all P ＜0.05],while the average diastolic pressure and diastolic variation were not different between the two groups(P ＞ 0.05) ; ②24 h ambulatory blood pressure and coronary artery diseas:systolic variation and diastolic pressure were significantly higher compared with group without coronary artery disease [(0.09 ±0.02) vs (0.07 ±0.02),(68 ±6)mm Hg vs (71 ±6)mm Hg,all P ＜0.05],while the diastolic variation were not different between these two groups(P ＞ 0.05) ; logistic regression analysis indicated that systolic variation was associated with coronary artery disease(r =3.719,P =0.025).Conclusion Blood pressure variability especially systolic variation is associated with carotid artery atherosclerosis and coronary disease.