中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
7期
917-918
,共2页
王志晔%张作念%潘振华%张进秋%顾伟%章慧%孙轶%潘锡近
王誌曄%張作唸%潘振華%張進鞦%顧偉%章慧%孫軼%潘錫近
왕지엽%장작념%반진화%장진추%고위%장혜%손질%반석근
同型半胱氨酸%脑梗死,急性%颈动脉粥样硬化
同型半胱氨痠%腦梗死,急性%頸動脈粥樣硬化
동형반광안산%뇌경사,급성%경동맥죽양경화
Homocysteine%Cerebral infarction,acute%Carotid artery atherosclerosis
目的 研究急性脑梗死患者血浆同型半胱氨酸(Hcy)水平与颈动脉粥样硬化的关系,对其发病机制进行初步探讨.方法 入选103例首次发病的急性脑梗死患者和46例健康体检者,应用颈动脉多普勒彩色超声检测颈动脉内膜中层厚度(IMT).用免疫比浊法测定血浆Hcy,并对检测结果进行统计学分析.结果 急性脑梗死组血浆Hcy水平明显高于对照组[(18.21±0.51) μmol/L比(12.32±0.16) μmol/L,P＜0.01]；脑梗死内膜增厚组、斑块组血浆Hcy明显高于无斑块组[(18.37 ±0.24)、(20.16±0.58) μmol/L比(13.25±0.13) μmol/L,P＜0.05]；斑块组血浆Hcy水平明显高于内膜增厚组(P＜0.05).直线相关分析显示血浆Hcy水平与IMT呈正相关(r=0.68,P＜0.01).结论 血浆Hcy水平与急性脑梗死患者动脉粥样硬化程度密切相关,对高Hcy脑梗死患者进行干预是一种值得研究的防治手段.
目的 研究急性腦梗死患者血漿同型半胱氨痠(Hcy)水平與頸動脈粥樣硬化的關繫,對其髮病機製進行初步探討.方法 入選103例首次髮病的急性腦梗死患者和46例健康體檢者,應用頸動脈多普勒綵色超聲檢測頸動脈內膜中層厚度(IMT).用免疫比濁法測定血漿Hcy,併對檢測結果進行統計學分析.結果 急性腦梗死組血漿Hcy水平明顯高于對照組[(18.21±0.51) μmol/L比(12.32±0.16) μmol/L,P＜0.01]；腦梗死內膜增厚組、斑塊組血漿Hcy明顯高于無斑塊組[(18.37 ±0.24)、(20.16±0.58) μmol/L比(13.25±0.13) μmol/L,P＜0.05]；斑塊組血漿Hcy水平明顯高于內膜增厚組(P＜0.05).直線相關分析顯示血漿Hcy水平與IMT呈正相關(r=0.68,P＜0.01).結論 血漿Hcy水平與急性腦梗死患者動脈粥樣硬化程度密切相關,對高Hcy腦梗死患者進行榦預是一種值得研究的防治手段.
목적 연구급성뇌경사환자혈장동형반광안산(Hcy)수평여경동맥죽양경화적관계,대기발병궤제진행초보탐토.방법 입선103례수차발병적급성뇌경사환자화46례건강체검자,응용경동맥다보륵채색초성검측경동맥내막중층후도(IMT).용면역비탁법측정혈장Hcy,병대검측결과진행통계학분석.결과 급성뇌경사조혈장Hcy수평명현고우대조조[(18.21±0.51) μmol/L비(12.32±0.16) μmol/L,P＜0.01]；뇌경사내막증후조、반괴조혈장Hcy명현고우무반괴조[(18.37 ±0.24)、(20.16±0.58) μmol/L비(13.25±0.13) μmol/L,P＜0.05]；반괴조혈장Hcy수평명현고우내막증후조(P＜0.05).직선상관분석현시혈장Hcy수평여IMT정정상관(r=0.68,P＜0.01).결론 혈장Hcy수평여급성뇌경사환자동맥죽양경화정도밀절상관,대고Hcy뇌경사환자진행간예시일충치득연구적방치수단.
Objective To investigate the relation between the serum homocysteine level in patients with acute cerebral infarction and carotid artery atherosclerosis.Methods In 103 patients with initial acute cerebral infarction and 46 healthy persons,carotid intima-medial wall thickness(IMT) was determined with colored doppler ultrasound; serum homocysteine level was determined with immunoturbidimetry.Results The serum homocysteine level in the patient group was significantly higher than that in control group[(18.21 ±0.51) μmol/L vs (12.32 ±0.16) μmol/L,P ＜ 0.01].The serum homocysteine level in the patients with carotid artery intima media thickness oratheromatous plaque was significantly higher than that in the patients without atheromatous plaque [(18.37 ±0.24),(20.16 ±0.58) μmol/L vs (13.25 ±0.13) μmol/L,P＜0.05].The serum homocysteine level of patients with atheromatous plaque was significantly higher than that of patients with carotid artery intima media thickness(P ＜0.05) ; the serum homocysteine level was positively correlated with intimal-medial wall thickness (r =0.68,P ＜0.01).Conclusion The serum homocysteine level is significantly correlated with the degree of atherosclerosis of patients with acute cerebral infarction.
