中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
8期
1043-1044
,共2页
潘从明%常青梅%郝世国%刘淑珍
潘從明%常青梅%郝世國%劉淑珍
반종명%상청매%학세국%류숙진
心房颤动%他汀类药物%辛伐他汀
心房顫動%他汀類藥物%辛伐他汀
심방전동%타정류약물%신벌타정
Atrial fibrillation%Statins drug%Simvastatin
目的 观察他汀类药物在心房颤动治疗中的作用.方法 将2008年1月至2011年1月阿拉善盟中心医院收治的86例持续性心房颤动患者完全随机分为他汀组和对照组,各43例.给予体外同步直流电复律后2组均给予胺碘酮200 mg、3次/d口服,1周后改为200 mg、2次/d,再1周后改为200 mg、1次/d维持；他汀组同时给予辛伐他汀20 mg,每晚1次口服.患者复律前后均给予华法林钠正规抗凝治疗,共治疗6个月.患者恢复窦性心律后1、2周及以后每4周分别行心电图和动态心电图检查.结果 他汀组维持窦性心律38例(88.4％),未维持窦性心律5例(11.6％)；对照组维持窦性心律29例(67.4％),未维持窦性心律14例(32.6％).他汀组维持窦性心律的比例明显高于对照组(P＜0.05).结论 他汀类药物在预防心房颤动复发上有应用价值.
目的 觀察他汀類藥物在心房顫動治療中的作用.方法 將2008年1月至2011年1月阿拉善盟中心醫院收治的86例持續性心房顫動患者完全隨機分為他汀組和對照組,各43例.給予體外同步直流電複律後2組均給予胺碘酮200 mg、3次/d口服,1週後改為200 mg、2次/d,再1週後改為200 mg、1次/d維持；他汀組同時給予辛伐他汀20 mg,每晚1次口服.患者複律前後均給予華法林鈉正規抗凝治療,共治療6箇月.患者恢複竇性心律後1、2週及以後每4週分彆行心電圖和動態心電圖檢查.結果 他汀組維持竇性心律38例(88.4％),未維持竇性心律5例(11.6％)；對照組維持竇性心律29例(67.4％),未維持竇性心律14例(32.6％).他汀組維持竇性心律的比例明顯高于對照組(P＜0.05).結論 他汀類藥物在預防心房顫動複髮上有應用價值.
목적 관찰타정류약물재심방전동치료중적작용.방법 장2008년1월지2011년1월아랍선맹중심의원수치적86례지속성심방전동환자완전수궤분위타정조화대조조,각43례.급여체외동보직류전복률후2조균급여알전동200 mg、3차/d구복,1주후개위200 mg、2차/d,재1주후개위200 mg、1차/d유지；타정조동시급여신벌타정20 mg,매만1차구복.환자복률전후균급여화법림납정규항응치료,공치료6개월.환자회복두성심률후1、2주급이후매4주분별행심전도화동태심전도검사.결과 타정조유지두성심률38례(88.4％),미유지두성심률5례(11.6％)；대조조유지두성심률29례(67.4％),미유지두성심률14례(32.6％).타정조유지두성심률적비례명현고우대조조(P＜0.05).결론 타정류약물재예방심방전동복발상유응용개치.
Objective To detect the role of statin drugs in the treatment of atrial fibrillation.Methods Totally 86 cases with atrial fibrillation were collected between January 2008 and January 2011.The patients were randomly divided into two groups.After being given in vitro synchronous dc after cardioerter,both groups had amiodarone 200 mg (200 mg/piece) with 3 times a day,200 mg with 2 times a day after one week,and 200 mg once a day for a long term.Statin group also had simvastatin 20 mg (20 mg/piece) every night.All patients were given warfarin sodium fomal anticoagulant therapy before and after cardioerter.Total treatment was for 6 months.Results The statin group showed sinus rhythm in 38 cases (88.4％) ; the control group showed sinus rhythm in 29 cases (67.4％).The proportion of sinus rhythm in simvastatin group was significantly higher than that in the control group (88.4％ vs 67.4％,P＜0.05).Conclusion Statins can prevent recurrence of atrial fibrillation.
