CAJ | 학술논문

目的分析糖尿病足坏疽(DFG)创面分离出的耐甲氧西林金黄色葡萄球菌(MRSA)的耐药性,指导临床合理应用抗生素.方法对空军总医院2008年1月至2011年12月期间610例住院DFG患者创面中分离的411株金黄色葡萄球菌,采用纸片扩散法进行药敏试验,用头孢西丁纸片扩散法筛选MRSA.结果检出的411株菌株中包括MRSA 164株、甲氧西林敏感金黄色葡萄球菌(MSSA) 247株,除青霉素、红霉素、克林霉素外,MSSA对其他抗生素均有较好的敏感性,而MRSA除对万古霉素、利奈唑胺、替考拉宁、呋喃妥因、氯霉素及复方新诺明敏感外,对其他抗生素均耐药.没有发现对万古霉素及利奈唑胺耐药的菌株.结论 MRSA多重耐药,在DFG患者中应加强对其发生率及耐药率监测,有效地预防及控制其感染.
목적 분석당뇨병족배저(DFG)창면분리출적내갑양서림금황색포도구균(MRSA)적내약성,지도림상합리응용항생소.방법 대공군총의원2008년1월지2011년12월기간610례주원DFG환자창면중분리적411주금황색포도구균,채용지편확산법진행약민시험,용두포서정지편확산법사선MRSA.결과 검출적411주균주중포괄MRSA 164주、갑양서림민감금황색포도구균(MSSA) 247주,제청매소、홍매소、극림매소외,MSSA대기타항생소균유교호적민감성,이MRSA제대만고매소、리내서알、체고랍저、부남타인、록매소급복방신낙명민감외,대기타항생소균내약.몰유발현대만고매소급리내서알내약적균주.결론 MRSA다중내약,재DFG환자중응가강대기발생솔급내약솔감측,유효지예방급공제기감염.
Objective To study the current situation of infection onset caused by methicillin-resistant staphylococcus aureus (MRSA) in diabetic foot gangrene,benefit clinical to select antibiotic for use reasonably,and prevent MRSA epidemic-outbreak.Approach the evidence for clinical prevention and cure.Methods The research was done to detect MRSA in 411 samples from patients suffering from diabetic foot gangrene in hospital which was infected by staphylococcus aureus from January 2008 to December 2011.Bacterial isolates were identified by API system,the susceptibility of antibiotics was performed by Kirby-Bauer method,and Kirby-Bauer method of cefoxitin was used to select meticillin-resistant Staphylococcus aureus MRSA.Results Of 411 strains of isolated staphylococcus aureus,164 strains were MRSA and 247 strains were meticillin-sensitive Staphylococcus aureus (MSSA).Except for penicillin,erythromycin and clindamycin,MSSA were sensitive to the other antibiotics.While MRSA were only sensitive to vancomycin,linezolid,teicoplanin,nitrofurantoin,chloramphenicol and trimetthoprim/sulfamethoxazolen,and were resistant to all other antibiotics.No strain which was resistant to vancomycin and linezolid was isolated.Conclusions MRSA is multidrug resistant.the drug resistances of MRSA should be monitored closely in diabetic foot gangrene to effectively prevent and control its infection.