中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
12期
1681-1683
,共3页
冠心病%女性%绝经%危险因素
冠心病%女性%絕經%危險因素
관심병%녀성%절경%위험인소
Coronary heart disease%Women%Menopause%Risk factors
目的 探讨绝经后女性冠心病患者中心血管相关危险因素对冠脉疾病发生及病变程度的影响.方法 入选因胸痛、胸闷拟诊冠心病行冠状动脉造影的绝经后女性患者453例.根据冠状动脉造影结果分为冠心病组(340例)和非冠心病组(113例),对2组患者的临床特点及冠状动脉病变特点进行统计学比较.结果 ①冠心病组和非冠心病组间年龄、收缩压、舒张压、脉压、TG、TC及LDL-C水平差异有统计学意义[(63±8)岁比(60±9)岁,(149±28) mm Hg(1mm Hg=0.133 kPa)比(128±14)mm Hg,(88±16)mm Hg比(78 ±8)mm Hg,(61±22)mm Hg比(50±12)mm Hg,(2.2±1.2) mmol/L比(1.8±1.0)mmol/L,(4.6±1.7) mmol/L比(4.8±1.0) mmol/L,(3.1 ±0.8)mmol/L比(2.1±0.8)mmol/L;均P＜0.05].②多因素回归分析显示,收缩压、脉压、TG、LDL-C为女性冠心病的独立危险因素(P＜0.05).相关危险度依次为TG、LDL-C、脉压、收缩压.③340例冠心病患者中,单支病变者103例,2支病变者114例,3支病变者123例.冠状动脉病变1、2、3支数者间年龄、LDL-C差异有统计学意义[年龄:(61±8)、(62±8)、(64±8)岁;LDL-C:(2.9±0.7)、(3.0±0.7)、(3.2±0.8) mmol/L;均P＜0.05].结论 心血管危险因素在女性绝经后冠心病的发生和发展中起重要作用,有效地对危险因素进行控制是开展女性冠心病一级预防的关键.
目的 探討絕經後女性冠心病患者中心血管相關危險因素對冠脈疾病髮生及病變程度的影響.方法 入選因胸痛、胸悶擬診冠心病行冠狀動脈造影的絕經後女性患者453例.根據冠狀動脈造影結果分為冠心病組(340例)和非冠心病組(113例),對2組患者的臨床特點及冠狀動脈病變特點進行統計學比較.結果 ①冠心病組和非冠心病組間年齡、收縮壓、舒張壓、脈壓、TG、TC及LDL-C水平差異有統計學意義[(63±8)歲比(60±9)歲,(149±28) mm Hg(1mm Hg=0.133 kPa)比(128±14)mm Hg,(88±16)mm Hg比(78 ±8)mm Hg,(61±22)mm Hg比(50±12)mm Hg,(2.2±1.2) mmol/L比(1.8±1.0)mmol/L,(4.6±1.7) mmol/L比(4.8±1.0) mmol/L,(3.1 ±0.8)mmol/L比(2.1±0.8)mmol/L;均P＜0.05].②多因素迴歸分析顯示,收縮壓、脈壓、TG、LDL-C為女性冠心病的獨立危險因素(P＜0.05).相關危險度依次為TG、LDL-C、脈壓、收縮壓.③340例冠心病患者中,單支病變者103例,2支病變者114例,3支病變者123例.冠狀動脈病變1、2、3支數者間年齡、LDL-C差異有統計學意義[年齡:(61±8)、(62±8)、(64±8)歲;LDL-C:(2.9±0.7)、(3.0±0.7)、(3.2±0.8) mmol/L;均P＜0.05].結論 心血管危險因素在女性絕經後冠心病的髮生和髮展中起重要作用,有效地對危險因素進行控製是開展女性冠心病一級預防的關鍵.
목적 탐토절경후녀성관심병환자중심혈관상관위험인소대관맥질병발생급병변정도적영향.방법 입선인흉통、흉민의진관심병행관상동맥조영적절경후녀성환자453례.근거관상동맥조영결과분위관심병조(340례)화비관심병조(113례),대2조환자적림상특점급관상동맥병변특점진행통계학비교.결과 ①관심병조화비관심병조간년령、수축압、서장압、맥압、TG、TC급LDL-C수평차이유통계학의의[(63±8)세비(60±9)세,(149±28) mm Hg(1mm Hg=0.133 kPa)비(128±14)mm Hg,(88±16)mm Hg비(78 ±8)mm Hg,(61±22)mm Hg비(50±12)mm Hg,(2.2±1.2) mmol/L비(1.8±1.0)mmol/L,(4.6±1.7) mmol/L비(4.8±1.0) mmol/L,(3.1 ±0.8)mmol/L비(2.1±0.8)mmol/L;균P＜0.05].②다인소회귀분석현시,수축압、맥압、TG、LDL-C위녀성관심병적독립위험인소(P＜0.05).상관위험도의차위TG、LDL-C、맥압、수축압.③340례관심병환자중,단지병변자103례,2지병변자114례,3지병변자123례.관상동맥병변1、2、3지수자간년령、LDL-C차이유통계학의의[년령:(61±8)、(62±8)、(64±8)세;LDL-C:(2.9±0.7)、(3.0±0.7)、(3.2±0.8) mmol/L;균P＜0.05].결론 심혈관위험인소재녀성절경후관심병적발생화발전중기중요작용,유효지대위험인소진행공제시개전녀성관심병일급예방적관건.
Objective To explore the effect of cardiac risk factors on the severity of coronary artery lesion in post menopausal women with coronary heart disease(CHD).Methods The study prospectively analyzed the post manopasual femal patients from 2012.9 to 2013.2 who were admitted for chest pain,chest tightness and got coronary angiography.According to the results of coronary angiography,the patients were divided into the CHD group (340 cases) and non-CHD group (113 cases).Results ①Single-variant analysis showed age,systolic blood pressure,diastolic blood pressure,pulse pressure,triglycerides,total cholesterol,low-density lipoprotein cholesterol (LDL-C) and risk factors had statistically significant difference between CHD group and non-CHD group [(63 ±8) old years vs (60 ± 9) old years,(149 ± 28) mm Hg(1 mm Hg=0.133 kPa) vs (128 ± 14) mm Hg,(88 ± 16) mm Hg vs (78 ±8) mm Hg,(61 ± 22)mm Hg vs (50 ± 12) mm Hg,(2.2 ± 1.2) mmol/L vs (1.8 ± 1.0) mmol/L,(4.6 ± 1.7) mmol/L vs (4.8 ± 1.0) mmol/L,(3.1 ± 0.8) mmol/L vs (2.1 ± 0.8) mmol/L; all P ＜ 0.05].②The multivariant logistic regression analysis showed systolic blood pressure,pulse pressure,triglyceride and LDL-C as an independent risk factors for women with CHD (P ＜ 0.05).Associated risk were as follows:triglycerides,LDL-C,pulse pressure,systolic blood pressure.③According to the degree of coronary artery disease,the coronary group patients were divided into single-vessel disease group (103 cases,30.3％),2-vessel disease group (114 cases,33.5％),3-vessel disease group (123 cases,36.2％).Age and LDL-C in coronary artery disease were significantly different among different groups[age:(61 ±8),(62 ±8),(64 ±8)old years; LDL-C:(2.9 ±0.7),(3.0 ±0.7),(3.2 ± 0.8) mmol/L; all P ＜ 0.05].Conclusion Cardiovascular risk factors plays an important role in postmenopausal women with CHD ; effectively controlling these risk factors is the key to prevention of CHD.
