中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
1期
17-20
,共4页
赵文度%张亮%卢家凯%程卫平
趙文度%張亮%盧傢凱%程衛平
조문도%장량%로가개%정위평
非体外循环冠状动脉搭桥术%喷他佐辛%镇痛
非體外循環冠狀動脈搭橋術%噴他佐辛%鎮痛
비체외순배관상동맥탑교술%분타좌신%진통
Off-pump coronary artery bypass grafting operation%Pentazocine%Analgesia
目的 观察非体外循环冠状动脉搭桥术后喷他佐辛的镇痛效果.方法 选取64例择期行非体外循环冠状动脉搭桥术男性患者,将其完全随机分为芬太尼组、喷他佐辛1组、喷他佐辛2组和喷他佐辛3组,每组16例,分别用喷他佐辛0.50、0.75、1.00 μg/kg加0.9％氯化钠溶液至200 ml.芬太尼组用芬太尼2 mg加0.9％氯化钠溶液至200 ml,每组均以2 ml/h的速度持续静脉泵入.记录患者连接止痛泵后4、8、12、24、36、48、72、96 h的视觉模拟评分(VAS)、Ram-Say镇静评分,不良反应和要求追加止痛剂的情况.结果 喷他佐辛1组8h和12 h VAS评分[(2.4±1.2)、(3.2±1.8)分]高于芬太尼组和喷他佐辛2、3组[(1.7±1.0)、(1.7±1.1)分;(1.9±1.1)、(1.9±1.2)分;(1.8±1.2)、(1.7±0.9)分],差异均有统计学意义(均P＜0.05).喷他佐辛1组镇痛优良率为68.7％(11例),喷他佐辛3组的镇痛优良率[100.0％(16例)]高于芬太尼组[87.5％(14例)](P＜0.05).结论 0.75 μg/kg喷他佐辛用于术后镇痛效果可靠,且不良反应发生率低于芬太尼,更适用于非体外循环冠状动脉搭桥术.
目的 觀察非體外循環冠狀動脈搭橋術後噴他佐辛的鎮痛效果.方法 選取64例擇期行非體外循環冠狀動脈搭橋術男性患者,將其完全隨機分為芬太尼組、噴他佐辛1組、噴他佐辛2組和噴他佐辛3組,每組16例,分彆用噴他佐辛0.50、0.75、1.00 μg/kg加0.9％氯化鈉溶液至200 ml.芬太尼組用芬太尼2 mg加0.9％氯化鈉溶液至200 ml,每組均以2 ml/h的速度持續靜脈泵入.記錄患者連接止痛泵後4、8、12、24、36、48、72、96 h的視覺模擬評分(VAS)、Ram-Say鎮靜評分,不良反應和要求追加止痛劑的情況.結果 噴他佐辛1組8h和12 h VAS評分[(2.4±1.2)、(3.2±1.8)分]高于芬太尼組和噴他佐辛2、3組[(1.7±1.0)、(1.7±1.1)分;(1.9±1.1)、(1.9±1.2)分;(1.8±1.2)、(1.7±0.9)分],差異均有統計學意義(均P＜0.05).噴他佐辛1組鎮痛優良率為68.7％(11例),噴他佐辛3組的鎮痛優良率[100.0％(16例)]高于芬太尼組[87.5％(14例)](P＜0.05).結論 0.75 μg/kg噴他佐辛用于術後鎮痛效果可靠,且不良反應髮生率低于芬太尼,更適用于非體外循環冠狀動脈搭橋術.
목적 관찰비체외순배관상동맥탑교술후분타좌신적진통효과.방법 선취64례택기행비체외순배관상동맥탑교술남성환자,장기완전수궤분위분태니조、분타좌신1조、분타좌신2조화분타좌신3조,매조16례,분별용분타좌신0.50、0.75、1.00 μg/kg가0.9％록화납용액지200 ml.분태니조용분태니2 mg가0.9％록화납용액지200 ml,매조균이2 ml/h적속도지속정맥빙입.기록환자련접지통빙후4、8、12、24、36、48、72、96 h적시각모의평분(VAS)、Ram-Say진정평분,불량반응화요구추가지통제적정황.결과 분타좌신1조8h화12 h VAS평분[(2.4±1.2)、(3.2±1.8)분]고우분태니조화분타좌신2、3조[(1.7±1.0)、(1.7±1.1)분;(1.9±1.1)、(1.9±1.2)분;(1.8±1.2)、(1.7±0.9)분],차이균유통계학의의(균P＜0.05).분타좌신1조진통우량솔위68.7％(11례),분타좌신3조적진통우량솔[100.0％(16례)]고우분태니조[87.5％(14례)](P＜0.05).결론 0.75 μg/kg분타좌신용우술후진통효과가고,차불량반응발생솔저우분태니,경괄용우비체외순배관상동맥탑교술.
Objective To observe the analgesic effect of pentazocine after off-pump coronary artery bypass grafting operation.Methods All 64 elective male patients undergoing off-pump coronary artery bypass grafting operation were randomized divided into fentanyl group(group F,n =16) and pentazocine group P1 (n =16),group P2(n =16) and group P3(n =16) group.In group F,2 mg fentanyl was diluted into 200 ml with saline.Each group had continuously intravenous infusion at the speed of 2 ml/h.Visual analogue scale (VAS),Ramsay sedation score,total analgesic comfortable score,adverse reactions and additional analgesics were recorded at 4,8,12,24,36,48,72,96 h after the analgesia pump was connected to patient.Results VAS score of group P1 [(2.4 ± 1.2),(3.2 ± 1.8) scores] was higher than that of other groups at 8 h and 12 h (P ＜ 0.05).The analgesic excellent rate of group P1 was 68.7％ (11/16) and the analgesic excellent rate of pentazocine group was higher than fentanyl group[100.0％ (16 cases) vs 87.5％ (14 cases),P ＜ 0.05].Conclusion Pentazocine can produce reliable postoperative analgesia for patients undergoing after off-pump coronary artery bypass grafting operation and the rate of adverse reactions is lower than fentanyl.
