中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
1期
32-36
,共5页
张雪艳%王慧敏%楼煜清%金波%韩宝惠
張雪豔%王慧敏%樓煜清%金波%韓寶惠
장설염%왕혜민%루욱청%금파%한보혜
肺肿瘤%B细胞特异性莫洛氏鼠白血病病毒插入位点1%预后
肺腫瘤%B細胞特異性莫洛氏鼠白血病病毒插入位點1%預後
폐종류%B세포특이성막락씨서백혈병병독삽입위점1%예후
Lung neoplasms%B-cell-specific moloney leukemia virus insert site 1%Prognosis
目的 检测肺腺癌组织中B细胞特异性莫洛氏鼠白血病病毒插入位点1(Bmi1)表达,并分析其与肺腺癌患者的转移、疗效及预后的相关性.方法 免疫组织化学方法检测肺腺癌组织Bmi1表达.x2检验分析Bmi1表达与临床病理指标的关系,以Kaplan-Meier生存曲线计算生存率,采用Cox分析评估各指标与患者生存之间的关系.结果 126例肺腺癌组织中,72例可观察到Bmi1阳性细胞,阳性率为57.1％.Bmi1表达与肺腺癌患者转移及化疗疗效密切相关(P=0.000或P=0.021),且与患者无病生存期和生存期呈明显负相关.多因素分析结果显示,转移、Bmi1表达以及转移后化疗疗效均是影响生存时间的独立因素[β值分别为-6.212、1.015、0.867,95％置信区间分别为0.000 ～ 0.019、1.727 ～ 4.405、1.680 ～3.372,均P=0.000].结论 Bmi1表达与肺腺癌患者的转移及化疗耐药相关,提示预后不良.
目的 檢測肺腺癌組織中B細胞特異性莫洛氏鼠白血病病毒插入位點1(Bmi1)錶達,併分析其與肺腺癌患者的轉移、療效及預後的相關性.方法 免疫組織化學方法檢測肺腺癌組織Bmi1錶達.x2檢驗分析Bmi1錶達與臨床病理指標的關繫,以Kaplan-Meier生存麯線計算生存率,採用Cox分析評估各指標與患者生存之間的關繫.結果 126例肺腺癌組織中,72例可觀察到Bmi1暘性細胞,暘性率為57.1％.Bmi1錶達與肺腺癌患者轉移及化療療效密切相關(P=0.000或P=0.021),且與患者無病生存期和生存期呈明顯負相關.多因素分析結果顯示,轉移、Bmi1錶達以及轉移後化療療效均是影響生存時間的獨立因素[β值分彆為-6.212、1.015、0.867,95％置信區間分彆為0.000 ～ 0.019、1.727 ～ 4.405、1.680 ～3.372,均P=0.000].結論 Bmi1錶達與肺腺癌患者的轉移及化療耐藥相關,提示預後不良.
목적 검측폐선암조직중B세포특이성막락씨서백혈병병독삽입위점1(Bmi1)표체,병분석기여폐선암환자적전이、료효급예후적상관성.방법 면역조직화학방법검측폐선암조직Bmi1표체.x2검험분석Bmi1표체여림상병리지표적관계,이Kaplan-Meier생존곡선계산생존솔,채용Cox분석평고각지표여환자생존지간적관계.결과 126례폐선암조직중,72례가관찰도Bmi1양성세포,양성솔위57.1％.Bmi1표체여폐선암환자전이급화료료효밀절상관(P=0.000혹P=0.021),차여환자무병생존기화생존기정명현부상관.다인소분석결과현시,전이、Bmi1표체이급전이후화료료효균시영향생존시간적독립인소[β치분별위-6.212、1.015、0.867,95％치신구간분별위0.000 ～ 0.019、1.727 ～ 4.405、1.680 ～3.372,균P=0.000].결론 Bmi1표체여폐선암환자적전이급화료내약상관,제시예후불량.
Objective To detect the B-cell-specific moloney leukemia virus insert site 1 (Bmi1)expression in lung adenocarcinoma tissues,and to analyze its relevance to the metastasis,chemotherapeutic effect and prognosis in lung adenocarcinoma patients.Methods The Bmi1 expression in lung adenocarcinoma tissues was detected by immunohistochemical methods.The relationship between Bmi1 expression and clinical pathological indicators was examined by chi-square test.The survival rate was calculated by Kaplan-Meier survivorship curve.The relevance between the indicators and the patient survival was estimated by COX analysis.Results Among the 126 lung adenocarcinoma tissue samples,Bmi1 positive cells were found in 91 tissues and the positive rate was 57.1％.Bmi1 expression was closely related to the metastasis and chemoresistance in lung adenocarcinoma patients (P =0.000 or P =0.021),and it was in significant negative correlation with the disease free survival period and survival period of the patients.The results of multiple factor analysis showed that transfer,the expression of Bmi1 and the effect of chemotherapy after transfer were the independent influencing factors of the survival time[β =-6.212,1.015,0.867,respectively,and the 95％ confidence interval:0.000-0.019,1.727-4.405,1.680-3.372,respectively,and all P =0.000].Conclusion Bmi1 expression is related to the metastasis and chemoresistance in lung adenocarcinoma patients and indicates a poor prognosis.
