中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
1期
54-57
,共4页
椎基底动脉供血不足%脑性眩晕%川芎清脑颗粒
椎基底動脈供血不足%腦性眩暈%川芎清腦顆粒
추기저동맥공혈불족%뇌성현훈%천궁청뇌과립
Vertebrobasilar insufficiency%Cerebral vertigo%Chuanxiong qingnao particles
目的 观察川芎清脑颗粒治疗椎基底动脉供血不足致脑性眩晕的临床效果.方法 选取湖南中医药大学第一附属医院2013年2-6月135例椎基底动脉供血不足脑性眩晕患者,随机数字表法将患者分为观察组(85例)和对照组(50例).观察组使用川芎清脑颗粒治疗,对照组使用晕痛定胶囊治疗,疗程均为4周.观察2组治疗前后症状、体征、经颅多普勒超声、血液流变学指标.结果 观察组的总有效率为97.6％(83/85),明显高于对照组[80.0％ (40/50)],差异有统计学意义(P＜0.05).治疗后观察组眩晕、头痛、耳鸣、恶心、头重等症状的总有效率与对照组比较[100.0％ (38/38)比81.8％ (18/22),100.0％(30/30)比83.3％(15/18),100.0％ (6/6)比75.0％ (3/4),85.7％(6/7)比75.0％(3/4),75.0％(3/4)比50.0％(1/2)],差异均有统计学意义(P＜0.05或P＜0.01).观察组治疗后多普勒超声大脑中动脉、大脑前动脉血流速度与治疗前比较[(13±3)mm/s比(23 ±4) mm/s,(8.2±2.2)mm/s比(3.8±3.2) mm/s],差异均有统计学意义(均P＜0.01).治疗后观察组大脑中动脉、大脑前动脉血流速度明显低于对照组[分别为(25±4)、(13.2 ±3.5)mm/s] (P ＜0.05).观察组治疗后低切、高切、中切全血比黏度与治疗前比较[(4.6±0.3)mPa/s比(3.0±0.2)mPa/s,(12.0±1.1) mPa/s比(13.6±1.1) mPa/s,(14.2±1.6) mPa/s比(17.1±1.9)mPa/s],差异均有统计学意义(均P＜0.05);治疗后观察组低切、高切、中切全血比黏度指标低于对照组[分别为(4.8±0.3)、(12.6±1.1)、(15.0±1.7)mPa/s],差异均有统计学意义(均P＜0.05).结论 川芎清脑颗粒对椎基底动脉供血不足的脑性眩晕有显著疗效,症状改善明显.
目的 觀察川芎清腦顆粒治療椎基底動脈供血不足緻腦性眩暈的臨床效果.方法 選取湖南中醫藥大學第一附屬醫院2013年2-6月135例椎基底動脈供血不足腦性眩暈患者,隨機數字錶法將患者分為觀察組(85例)和對照組(50例).觀察組使用川芎清腦顆粒治療,對照組使用暈痛定膠囊治療,療程均為4週.觀察2組治療前後癥狀、體徵、經顱多普勒超聲、血液流變學指標.結果 觀察組的總有效率為97.6％(83/85),明顯高于對照組[80.0％ (40/50)],差異有統計學意義(P＜0.05).治療後觀察組眩暈、頭痛、耳鳴、噁心、頭重等癥狀的總有效率與對照組比較[100.0％ (38/38)比81.8％ (18/22),100.0％(30/30)比83.3％(15/18),100.0％ (6/6)比75.0％ (3/4),85.7％(6/7)比75.0％(3/4),75.0％(3/4)比50.0％(1/2)],差異均有統計學意義(P＜0.05或P＜0.01).觀察組治療後多普勒超聲大腦中動脈、大腦前動脈血流速度與治療前比較[(13±3)mm/s比(23 ±4) mm/s,(8.2±2.2)mm/s比(3.8±3.2) mm/s],差異均有統計學意義(均P＜0.01).治療後觀察組大腦中動脈、大腦前動脈血流速度明顯低于對照組[分彆為(25±4)、(13.2 ±3.5)mm/s] (P ＜0.05).觀察組治療後低切、高切、中切全血比黏度與治療前比較[(4.6±0.3)mPa/s比(3.0±0.2)mPa/s,(12.0±1.1) mPa/s比(13.6±1.1) mPa/s,(14.2±1.6) mPa/s比(17.1±1.9)mPa/s],差異均有統計學意義(均P＜0.05);治療後觀察組低切、高切、中切全血比黏度指標低于對照組[分彆為(4.8±0.3)、(12.6±1.1)、(15.0±1.7)mPa/s],差異均有統計學意義(均P＜0.05).結論 川芎清腦顆粒對椎基底動脈供血不足的腦性眩暈有顯著療效,癥狀改善明顯.
목적 관찰천궁청뇌과립치료추기저동맥공혈불족치뇌성현훈적림상효과.방법 선취호남중의약대학제일부속의원2013년2-6월135례추기저동맥공혈불족뇌성현훈환자,수궤수자표법장환자분위관찰조(85례)화대조조(50례).관찰조사용천궁청뇌과립치료,대조조사용훈통정효낭치료,료정균위4주.관찰2조치료전후증상、체정、경로다보륵초성、혈액류변학지표.결과 관찰조적총유효솔위97.6％(83/85),명현고우대조조[80.0％ (40/50)],차이유통계학의의(P＜0.05).치료후관찰조현훈、두통、이명、악심、두중등증상적총유효솔여대조조비교[100.0％ (38/38)비81.8％ (18/22),100.0％(30/30)비83.3％(15/18),100.0％ (6/6)비75.0％ (3/4),85.7％(6/7)비75.0％(3/4),75.0％(3/4)비50.0％(1/2)],차이균유통계학의의(P＜0.05혹P＜0.01).관찰조치료후다보륵초성대뇌중동맥、대뇌전동맥혈류속도여치료전비교[(13±3)mm/s비(23 ±4) mm/s,(8.2±2.2)mm/s비(3.8±3.2) mm/s],차이균유통계학의의(균P＜0.01).치료후관찰조대뇌중동맥、대뇌전동맥혈류속도명현저우대조조[분별위(25±4)、(13.2 ±3.5)mm/s] (P ＜0.05).관찰조치료후저절、고절、중절전혈비점도여치료전비교[(4.6±0.3)mPa/s비(3.0±0.2)mPa/s,(12.0±1.1) mPa/s비(13.6±1.1) mPa/s,(14.2±1.6) mPa/s비(17.1±1.9)mPa/s],차이균유통계학의의(균P＜0.05);치료후관찰조저절、고절、중절전혈비점도지표저우대조조[분별위(4.8±0.3)、(12.6±1.1)、(15.0±1.7)mPa/s],차이균유통계학의의(균P＜0.05).결론 천궁청뇌과립대추기저동맥공혈불족적뇌성현훈유현저료효,증상개선명현.
Objective To explore clinical efficacy of Chuanxiong qingnao particles in the treatment of cerebral vertigo caused by vertebrobasilar insufficiency.Methods All 135 patients of vertebra-basilar ischemic vertigo in the first affiliated hospital of Hu'nan Chinese medicine university from February 2013 to June 2013 were selected and divided into observation group (85 ceases) and control group (50 ceases),observation group was given Chuanxiong qingnao particles,and control group was given halo carbamazepine capsules,course of treatment of two groups were 4 weeks.Symptoms,Doppler ultrasound results and blood rheology before and after treatment of two groups were observed.Results The total effective rate in the observation group was 97.6％ (83/85),significantly higher than that in the control group [80.0％ (40/50)] ; the difference was statistically significant (P ＜0.05) ; the total effective rate of vertigo,tinnitus,nausea,heavy head in observation group after treatment were significantly better than those in the control group [100.0％ (38/38) vs 81.8％ (18/22),100.0％ (30/30) vs 83.3％(15/18),100.0％ (6/6) vs 75.0％ (3/4),85.7％ (6/7) vs 75.0％ (3/4),75.0％ (3/4) vs 50.0％ (1/2)] (P ＜ 0.05 or P ＜ 0.01).There were significant differences on blood flow velocity of middle cerebral artery and anterior cerebral artery in observation group after treatment [(13 ± 3) mm/s vs (23 ± 4) mm/s,(8.2 ±2.2) mm/s vs (3.8 ± 3.2) mm/s] (P ＜ 0.05).Blood flow velocity of middle cerebral artery and anterior cerebral artery in observation group after treatment were lower than those of control group [(25 ± 4),(13.2 ±3.5) mrn/s] (P ＜0.05).There were significant differences on whole blood viscosity of low,high and midst shear in observation group after treatment [(4.6 ± 0.3) mPa/s vs (3.0 ± 0.2) mPa/s,(12.0 ± 1.1) mPa/s vs (13.6 ±1.1) mPa/s,(14.2 ± 1.6) mPa/s vs (17.1 ± 1.9) mPa/s] (P ＜ 0.05).Whole blood viscosity of low,high and midst shear in observation group after treatment were lower than those in control group [(4.8 ±0.3),(12.6 ±1.1),(15.0±1.7) mPa/s]; there were significant differences (P＜0.05).Conclusion Chuanxiong qingnao particles in the treatment of cerebral vertigo caused by vertebrobasilar insufficiency is effective and safe.
