中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
6期
887-889
,共3页
刘向东%艾子敏%马海军%朱铁锤
劉嚮東%艾子敏%馬海軍%硃鐵錘
류향동%애자민%마해군%주철추
儿童过敏性紫癜%中性粒细胞明胶酶相关脂质运载蛋白%胱抑素C%免疫球蛋白
兒童過敏性紫癜%中性粒細胞明膠酶相關脂質運載蛋白%胱抑素C%免疫毬蛋白
인동과민성자전%중성립세포명효매상관지질운재단백%광억소C%면역구단백
Henoch-schonlein purpura%Neutrophil gelatinase associated lipocalin%Cystatin C%Immunoglobulin
目的 探讨中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、胱抑素C和免疫球蛋白水平检测在儿童过敏性紫癜(HSP)早期肾损害诊断中的应用价值及相关性.方法 将60例患儿分为HSP普通型组30例、HSP肾型组30例,完全随机选择同期门诊体检正常儿童30例为对照组,检测受试者血浆NGAL、尿胱抑素和免疫球蛋白(IgA、IgM、IgG)的水平,进行比较分析.结果 HSP普通型组NGAL、胱抑素C和IgA水平分别为(1.6 ±0.4)mg/L,(1.4 ±0.6)mg/L,(1.8 ±0.5)g/L,HSP肾型组分别为(2.4 ± 1.1)mg/L,(3.6 ± 1.0) mg/L,(2.3 ±0.5)g/L,对照组分别为(0.3 ±0.1)mg/L,(0.5 ± 0.1)mg/L,(1.1 ±0.6)g/L,3组患儿NGAL、胱抑素C和IgA水平比较,差异有统计学意义(P＜0.05);HSP普通型组IgM、IgG水平分别为(1.2 ±0.1)g/L,(9.9 ±2.1)g/L,HSP肾型组(1.3 ±0.2) g/L,(9.4 ± 3.5) g/L,对照组(1.3±0.4)g/L,(9.4 ±4.0)g/L,3组IgM、IgG之间比较,差异无统计学意义(P＞0.05).HSP肾型组较NGAL、胱抑素C和IgA含量高于对照组与HSP普通型组,差异均有统计学意义(均P＜0.05);NGAL与胱抑素C呈正相关(r=12.36,P＜0.05);NGAL与IgA呈正相关(r=17.01,P＜0.05);胱抑素C与IgA呈正相关(r=22.25,P＜0.05).结论 NGAL、胱抑素C和免疫球蛋白水平对于HSP的诊断有一定价值,尤其对患儿肾功能早期损害的诊断,早期联合检测三者的水平,适时给予预防性治疗,对保护HSP患儿的脏器功能、改善预后具有重要临床意义.
目的 探討中性粒細胞明膠酶相關脂質運載蛋白(NGAL)、胱抑素C和免疫毬蛋白水平檢測在兒童過敏性紫癜(HSP)早期腎損害診斷中的應用價值及相關性.方法 將60例患兒分為HSP普通型組30例、HSP腎型組30例,完全隨機選擇同期門診體檢正常兒童30例為對照組,檢測受試者血漿NGAL、尿胱抑素和免疫毬蛋白(IgA、IgM、IgG)的水平,進行比較分析.結果 HSP普通型組NGAL、胱抑素C和IgA水平分彆為(1.6 ±0.4)mg/L,(1.4 ±0.6)mg/L,(1.8 ±0.5)g/L,HSP腎型組分彆為(2.4 ± 1.1)mg/L,(3.6 ± 1.0) mg/L,(2.3 ±0.5)g/L,對照組分彆為(0.3 ±0.1)mg/L,(0.5 ± 0.1)mg/L,(1.1 ±0.6)g/L,3組患兒NGAL、胱抑素C和IgA水平比較,差異有統計學意義(P＜0.05);HSP普通型組IgM、IgG水平分彆為(1.2 ±0.1)g/L,(9.9 ±2.1)g/L,HSP腎型組(1.3 ±0.2) g/L,(9.4 ± 3.5) g/L,對照組(1.3±0.4)g/L,(9.4 ±4.0)g/L,3組IgM、IgG之間比較,差異無統計學意義(P＞0.05).HSP腎型組較NGAL、胱抑素C和IgA含量高于對照組與HSP普通型組,差異均有統計學意義(均P＜0.05);NGAL與胱抑素C呈正相關(r=12.36,P＜0.05);NGAL與IgA呈正相關(r=17.01,P＜0.05);胱抑素C與IgA呈正相關(r=22.25,P＜0.05).結論 NGAL、胱抑素C和免疫毬蛋白水平對于HSP的診斷有一定價值,尤其對患兒腎功能早期損害的診斷,早期聯閤檢測三者的水平,適時給予預防性治療,對保護HSP患兒的髒器功能、改善預後具有重要臨床意義.
목적 탐토중성립세포명효매상관지질운재단백(NGAL)、광억소C화면역구단백수평검측재인동과민성자전(HSP)조기신손해진단중적응용개치급상관성.방법 장60례환인분위HSP보통형조30례、HSP신형조30례,완전수궤선택동기문진체검정상인동30례위대조조,검측수시자혈장NGAL、뇨광억소화면역구단백(IgA、IgM、IgG)적수평,진행비교분석.결과 HSP보통형조NGAL、광억소C화IgA수평분별위(1.6 ±0.4)mg/L,(1.4 ±0.6)mg/L,(1.8 ±0.5)g/L,HSP신형조분별위(2.4 ± 1.1)mg/L,(3.6 ± 1.0) mg/L,(2.3 ±0.5)g/L,대조조분별위(0.3 ±0.1)mg/L,(0.5 ± 0.1)mg/L,(1.1 ±0.6)g/L,3조환인NGAL、광억소C화IgA수평비교,차이유통계학의의(P＜0.05);HSP보통형조IgM、IgG수평분별위(1.2 ±0.1)g/L,(9.9 ±2.1)g/L,HSP신형조(1.3 ±0.2) g/L,(9.4 ± 3.5) g/L,대조조(1.3±0.4)g/L,(9.4 ±4.0)g/L,3조IgM、IgG지간비교,차이무통계학의의(P＞0.05).HSP신형조교NGAL、광억소C화IgA함량고우대조조여HSP보통형조,차이균유통계학의의(균P＜0.05);NGAL여광억소C정정상관(r=12.36,P＜0.05);NGAL여IgA정정상관(r=17.01,P＜0.05);광억소C여IgA정정상관(r=22.25,P＜0.05).결론 NGAL、광억소C화면역구단백수평대우HSP적진단유일정개치,우기대환인신공능조기손해적진단,조기연합검측삼자적수평,괄시급여예방성치료,대보호HSP환인적장기공능、개선예후구유중요림상의의.
Objective To discuss the application value and correlation of the detection of neutrophil gelatinase associated lipocalin(NGAL),cystatin C and immunoglobulin levels in the diagnosis of early kidney injury in henoch-schonlein purpura(HSP) patients.Methods Sixty patients with HSP were divided into HSP normal type group(30 cases) and HSP kidnev injury type group (30 cases).60 physical examination children were randomly chosen as control group.Results In HSP normal type group,NGAL,cystatin C and IgA levels were (1.6 ± 0.4)mg/L,(1.4±0.6)mg/L,(1.8±0.5)g/L.In HSP kidney injury type group,NGAL,cystatin C and IgA levels were (2.4±1.1)mg/L,(3.6±1.0)mg/L,(2.3 ±0.5)g/L.In control group,NGAL,cystatin C and IgA levels were (0.3 40.1)mg/L,(0.5 ±0.1)mg/L,(1.1 ±0.6)g/L.Levels of NGAL,cystatin C and IgA between the three groups showed statistical difference(P ＜ 0.05).In HSP normal type group,IgM and IgG levels were (1.2±0.1) g/L,(9.9±2.1)g/L.In HSP kidney injury type group,IgM and IgG levels were (1.3± 0.2) g/L,(9.4 ± 3.5) g/L.In control group,IgM and lgG levels were (1.3 ± 0.4) g/L,(9.4 ± 4.0) g/L.IgG and IgM levels between the three groups showed no significant difference(P ＞ 0.05).The levels of NGAL,cystatin C and IgA in two HSP groups were statistically increased compared with control group(x2 =22.4,28.3,19.7,P ＜ 0.05).The levels of NGAL,cvstatin C and IgA in HSP kidney injury type group were statistically increased compared with those in HSP normal type group(x2 =25.7,32.6,22.1,P ＜ 0.05).NGAL was positively crrelated to cvstatin C(r =12.36,P ＜ 0.05).NGAL was positively crrelated to IgA(r =17.01,P ＜ 0.05); cystatin C was positively crrelated to IgA (r =22.25,P ＜ 0.05).Conclusions NGAL,cystatin C and immunoglobulin levels are valuable in the diagnosis of HSP,especially in the patients with early kidney injury.Detection of these indexes at early stage and timely prevention treatment is important to protect the organ functions and improve the prognosis.
