中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
7期
963-967
,共5页
钱伟莉%杨新春%张娟%刘明莉
錢偉莉%楊新春%張娟%劉明莉
전위리%양신춘%장연%류명리
慢性充血性心力衰竭%同型半胱氨酸%高敏C反应蛋白
慢性充血性心力衰竭%同型半胱氨痠%高敏C反應蛋白
만성충혈성심력쇠갈%동형반광안산%고민C반응단백
Chronic heart failure%Homocysteine%high sensitivity C-reactive protein
目的 探讨血浆同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)水平与慢性充血性心力衰竭及其严重程度的关系.方法 对59例慢性充血性心力衰竭患者(心力衰竭组,其中心功能Ⅱ、Ⅲ、Ⅳ级者分别为14、29、16例)及29例心功能正常者(对照组)测定Hcy、hs-CRP水平,同时用心脏彩色多普勒超声心动仪测定左心室射血分数(LVEF)和左心室舒张末期内径(LVDD).采用Spcarman相关分析法分析Hcy、hs-CRP水平与LVEF及LVDD的相关性.结果 心力衰竭组患者血浆Hcy、hs-CRP水平均明显高于对照组,差异有统计学意义[心功能Ⅱ级组、心功能Ⅲ级组、心功能Ⅳ级组与对照组Hcy分别为(14.6±1.4)、(19.3±4.5)、(29.6±6.6)(9.4±1.2)μmol/L; hs-CRP分别为(4.2±2.2)、(12.6±3.7)、(14.7±2.6)、(3.7±1.4)mg/L;均P＜0.01],且随心功能分级增加,心力衰竭组患者血浆Hcy、hs-CRP水平均明显增高,差异有统计学意义(P＜0.01).Hcy与心功能分级(r=0.769,P＜0.05)和LVDD(r=0.706,P＜0.05)呈明显正相关,与LVEF呈明显负相关(r=-0.856,P＜0.05);hs-CRP水平与心功能分级(r=0.377,P=0.02)呈明显正相关,与LVDD(r =0.347,P=0.072)和LVEF(r=0.204,P=0.058)无明显相关.结论 心力衰竭患者HCY、hs-CRP随心力衰竭程度的加重而相应升高,Hcy与心功能分级有良好的相关性,对心力衰竭患者的诊断及预后有较好预测价值.
目的 探討血漿同型半胱氨痠(Hcy)、高敏C反應蛋白(hs-CRP)水平與慢性充血性心力衰竭及其嚴重程度的關繫.方法 對59例慢性充血性心力衰竭患者(心力衰竭組,其中心功能Ⅱ、Ⅲ、Ⅳ級者分彆為14、29、16例)及29例心功能正常者(對照組)測定Hcy、hs-CRP水平,同時用心髒綵色多普勒超聲心動儀測定左心室射血分數(LVEF)和左心室舒張末期內徑(LVDD).採用Spcarman相關分析法分析Hcy、hs-CRP水平與LVEF及LVDD的相關性.結果 心力衰竭組患者血漿Hcy、hs-CRP水平均明顯高于對照組,差異有統計學意義[心功能Ⅱ級組、心功能Ⅲ級組、心功能Ⅳ級組與對照組Hcy分彆為(14.6±1.4)、(19.3±4.5)、(29.6±6.6)(9.4±1.2)μmol/L; hs-CRP分彆為(4.2±2.2)、(12.6±3.7)、(14.7±2.6)、(3.7±1.4)mg/L;均P＜0.01],且隨心功能分級增加,心力衰竭組患者血漿Hcy、hs-CRP水平均明顯增高,差異有統計學意義(P＜0.01).Hcy與心功能分級(r=0.769,P＜0.05)和LVDD(r=0.706,P＜0.05)呈明顯正相關,與LVEF呈明顯負相關(r=-0.856,P＜0.05);hs-CRP水平與心功能分級(r=0.377,P=0.02)呈明顯正相關,與LVDD(r =0.347,P=0.072)和LVEF(r=0.204,P=0.058)無明顯相關.結論 心力衰竭患者HCY、hs-CRP隨心力衰竭程度的加重而相應升高,Hcy與心功能分級有良好的相關性,對心力衰竭患者的診斷及預後有較好預測價值.
목적 탐토혈장동형반광안산(Hcy)、고민C반응단백(hs-CRP)수평여만성충혈성심력쇠갈급기엄중정도적관계.방법 대59례만성충혈성심력쇠갈환자(심력쇠갈조,기중심공능Ⅱ、Ⅲ、Ⅳ급자분별위14、29、16례)급29례심공능정상자(대조조)측정Hcy、hs-CRP수평,동시용심장채색다보륵초성심동의측정좌심실사혈분수(LVEF)화좌심실서장말기내경(LVDD).채용Spcarman상관분석법분석Hcy、hs-CRP수평여LVEF급LVDD적상관성.결과 심력쇠갈조환자혈장Hcy、hs-CRP수평균명현고우대조조,차이유통계학의의[심공능Ⅱ급조、심공능Ⅲ급조、심공능Ⅳ급조여대조조Hcy분별위(14.6±1.4)、(19.3±4.5)、(29.6±6.6)(9.4±1.2)μmol/L; hs-CRP분별위(4.2±2.2)、(12.6±3.7)、(14.7±2.6)、(3.7±1.4)mg/L;균P＜0.01],차수심공능분급증가,심력쇠갈조환자혈장Hcy、hs-CRP수평균명현증고,차이유통계학의의(P＜0.01).Hcy여심공능분급(r=0.769,P＜0.05)화LVDD(r=0.706,P＜0.05)정명현정상관,여LVEF정명현부상관(r=-0.856,P＜0.05);hs-CRP수평여심공능분급(r=0.377,P=0.02)정명현정상관,여LVDD(r =0.347,P=0.072)화LVEF(r=0.204,P=0.058)무명현상관.결론 심력쇠갈환자HCY、hs-CRP수심력쇠갈정도적가중이상응승고,Hcy여심공능분급유량호적상관성,대심력쇠갈환자적진단급예후유교호예측개치.
Objective To investigate the effects of homocysteine(Hcy) and high sensitivity C-reactive protein (hs-CRP) on chronic heart failure [including cardiac function classification,left ventricular diastolic diameter (LVDD),left ventricular ejection fraction(LVEF)].Methods The plasma levels of HCY and CRP were tested in 59 patients with heart failure (heart failure group) and 29 healthy volunteers (control group).The LVDD and LVEF were detected by colour Doppler ultrasound.Results HCY of heart function Ⅱ group,NYHA Ⅲ group,NYHA Ⅳ group and the control group were (14.6 ± 1.4) μmol/L,(19.3 ±4.5) μmol/L,(29.6 ± 6.6) μmol/L (9.4 ± 1.2) μmol/L,respectively; hs-CRP were (4.2 ± 2.2) mg/L,(12.6 ± 3.7) mg/L,(14.7 ± 2.6) mg/L,(3.7 ± 1.4) mg/L,respectively.The levels of HCY and hs-CRP increased with cardiac function.The plasma level of Hcy was positively correlated with the severity of NYHA class (r =0.769,P ＜ 0.05) and LVDD(r =0.706,P ＜ 0.05),but it was negatively correlated with LVEF (r =-0.856,P ＜ 0.05).The plasma level of hs-CRP was positively correlated with the severity of NYHA class (r =0.377,P =0.02),but it was not correlated with LVDD (r=0.347,P=0.072)and LVEF(r =0.204,P=0.058).Conclusions The levels of Hcy and hs-CRP are increased with severity of NYHA class.The level of Hcy has correlations with the heart function.
