中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
7期
1031-1033
,共3页
氟比洛芬酯%镇痛%炎性因子
氟比洛芬酯%鎮痛%炎性因子
불비락분지%진통%염성인자
Flurbiprofen axetil%Analgesia%Inflammatory factors
目的 观察氟比洛芬酯镇痛对腹腔镜直肠癌根治术患者术后炎性因子及镇痛效果的影响.方法 选择2012年6月至2013年3月山东省聊城市人民医院择期行腹腔镜直肠癌根治术患者80例,完全随机分为试验组和对照组,每组40例.试验组患者于手术前30 min静脉注射氟比洛芬酯50 mg(5 ml),对照组患者静脉注射0.9％氯化钠注射液5 ml.分别在用药前10 min及术后即刻、12h、24 h采集静脉血,测定血浆P物质、白细胞介素6(IL-6)的浓度.采用视觉模拟评分(VAS)评价术后2、6、12、24 h的镇痛效果.结果 2组术后即刻、12hP物质浓度均高于本组基础值,差异均有统计学意义[对照组:(155 ± 24)、(155 ±31) ng/L比(90 ±8) ng/L,试验组(105±13)、(111±12) ng/L比(92 ± 10) ng/L,均P＜0.05],术后24 h与本组基础值的差异无统计学意义(P＞0.05).2组术后即刻、12h、24 h IL-6浓度高于基础值,差异有统计学意义[对照组:(73 ± 15)、(85±17)、(73±8) ng/L比(15±5)ng/L,试验组:(32±8)、(26±8)、(20 ±8)ng/L比(15±6) ng/L,均P＜0.05].试验组术后即刻及术后12hP物质浓度均低于对照组同时点,差异有统计学意义(P＜0.05);2组术后24hP物质浓度的差异无统计学意义(P＞0.05).试验组血浆IL-6浓度在术后即刻、术后12h和24 h均低于对照组,差异有统计学意义(P＜0.05).试验组术后2、12 h VAS评分均明显低于对照组[(2.1±0.6)分比(5.6±0.5)分,(1.9±0.9)分比(4.7±0.5)分,P＜0.05],术后6 h VAS评分高于对照组[(2.4±0.5)分比(2.2±0.4)分],差异均有统计学意义(均P＜0.05),2组术后24 h VAS评分差异无统计学意义(P＞0.05).结论 腹腔镜直肠癌根治术前给予氟比洛芬酯可降低炎性因子的产生,具有良好的镇痛效应.
目的 觀察氟比洛芬酯鎮痛對腹腔鏡直腸癌根治術患者術後炎性因子及鎮痛效果的影響.方法 選擇2012年6月至2013年3月山東省聊城市人民醫院擇期行腹腔鏡直腸癌根治術患者80例,完全隨機分為試驗組和對照組,每組40例.試驗組患者于手術前30 min靜脈註射氟比洛芬酯50 mg(5 ml),對照組患者靜脈註射0.9％氯化鈉註射液5 ml.分彆在用藥前10 min及術後即刻、12h、24 h採集靜脈血,測定血漿P物質、白細胞介素6(IL-6)的濃度.採用視覺模擬評分(VAS)評價術後2、6、12、24 h的鎮痛效果.結果 2組術後即刻、12hP物質濃度均高于本組基礎值,差異均有統計學意義[對照組:(155 ± 24)、(155 ±31) ng/L比(90 ±8) ng/L,試驗組(105±13)、(111±12) ng/L比(92 ± 10) ng/L,均P＜0.05],術後24 h與本組基礎值的差異無統計學意義(P＞0.05).2組術後即刻、12h、24 h IL-6濃度高于基礎值,差異有統計學意義[對照組:(73 ± 15)、(85±17)、(73±8) ng/L比(15±5)ng/L,試驗組:(32±8)、(26±8)、(20 ±8)ng/L比(15±6) ng/L,均P＜0.05].試驗組術後即刻及術後12hP物質濃度均低于對照組同時點,差異有統計學意義(P＜0.05);2組術後24hP物質濃度的差異無統計學意義(P＞0.05).試驗組血漿IL-6濃度在術後即刻、術後12h和24 h均低于對照組,差異有統計學意義(P＜0.05).試驗組術後2、12 h VAS評分均明顯低于對照組[(2.1±0.6)分比(5.6±0.5)分,(1.9±0.9)分比(4.7±0.5)分,P＜0.05],術後6 h VAS評分高于對照組[(2.4±0.5)分比(2.2±0.4)分],差異均有統計學意義(均P＜0.05),2組術後24 h VAS評分差異無統計學意義(P＞0.05).結論 腹腔鏡直腸癌根治術前給予氟比洛芬酯可降低炎性因子的產生,具有良好的鎮痛效應.
목적 관찰불비락분지진통대복강경직장암근치술환자술후염성인자급진통효과적영향.방법 선택2012년6월지2013년3월산동성료성시인민의원택기행복강경직장암근치술환자80례,완전수궤분위시험조화대조조,매조40례.시험조환자우수술전30 min정맥주사불비락분지50 mg(5 ml),대조조환자정맥주사0.9％록화납주사액5 ml.분별재용약전10 min급술후즉각、12h、24 h채집정맥혈,측정혈장P물질、백세포개소6(IL-6)적농도.채용시각모의평분(VAS)평개술후2、6、12、24 h적진통효과.결과 2조술후즉각、12hP물질농도균고우본조기출치,차이균유통계학의의[대조조:(155 ± 24)、(155 ±31) ng/L비(90 ±8) ng/L,시험조(105±13)、(111±12) ng/L비(92 ± 10) ng/L,균P＜0.05],술후24 h여본조기출치적차이무통계학의의(P＞0.05).2조술후즉각、12h、24 h IL-6농도고우기출치,차이유통계학의의[대조조:(73 ± 15)、(85±17)、(73±8) ng/L비(15±5)ng/L,시험조:(32±8)、(26±8)、(20 ±8)ng/L비(15±6) ng/L,균P＜0.05].시험조술후즉각급술후12hP물질농도균저우대조조동시점,차이유통계학의의(P＜0.05);2조술후24hP물질농도적차이무통계학의의(P＞0.05).시험조혈장IL-6농도재술후즉각、술후12h화24 h균저우대조조,차이유통계학의의(P＜0.05).시험조술후2、12 h VAS평분균명현저우대조조[(2.1±0.6)분비(5.6±0.5)분,(1.9±0.9)분비(4.7±0.5)분,P＜0.05],술후6 h VAS평분고우대조조[(2.4±0.5)분비(2.2±0.4)분],차이균유통계학의의(균P＜0.05),2조술후24 h VAS평분차이무통계학의의(P＞0.05).결론 복강경직장암근치술전급여불비락분지가강저염성인자적산생,구유량호적진통효응.
Objective To investigate the effects of flurbiprofen axetil analgesia on inflammatory factors and postoperative analgesia in patients undergoing laparoscopic radical rectectomy for rectal cancer.Methods Eighty patients undergoing laparoscopic radical rectectomy for rectal cancer were randomly divided into 2 groups (n =40 in each),flurbiprofen axetil group received intravenous flurbiprofen axetil 50mg/5 ml 30 minutes before anesthesia induction,and control group received normal saline 5 ml instead.Venous blood samples were obtained at 10 minutes before flurbiprofen axetil or normal saline was injected,mimediately when surgery was finished,12 hours,and 24 hour safter the surgery w as finished,to determine the plasma levels of substance P and IL-6.At the same time,visual analogue scale(VAS) scores were recorded at 2,6,12 and 24 hours after the surgery.Results Compared to the control group,the plasma levels of substance P decreased in the flurbiprofen axetil group at immediately when surgery was finished and 12 hours [mimediately when surgery was finished:(105 ± 13)ng/L vs (155 ±24) ng/L,12 hours:(111 ± 12) ng/L vs(155 ± 31) ng/L,10 minutes:(92 ± 10) ng/L vs(90 ± 8) ng/L,P ＜0.05].The plasma levels of IL-6 decreased in the flurbiprofen axetil group at immediately when surgery was finished to 24 hours [mimediately when surgery was finished:(32 ± 8) ng/L vs (73 ± 15) ng/L,12 hours:(26 ±8) ng/L vs (85 ± 17) ng/L,24 hours:(20±8) ng/L vs (73 ±8)ng/L,10 minutes:(15 ±6)ng/L vs (15 ±5)ng/L,P ＜0.05].VAS status had significant difference at 2,6 and 12 hours postoperatively in the flurbiprofen axetil group compared to the control group [(2.1 ± 0.6) scores vs (5.6 ± 0.5) scores,(2.4 ± 0.5) scores vs (2.2 ±0.4) scores,(1.9 ± 0.9) scores vs (4.7 ± 0.5) scores,P ＜ 0.05].Conclusion flurbiprofen axetil can reduce the production of in flammatory factors and produce better analgesia effect.
