中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
7期
1040-1042
,共3页
马合苏提%靳宏勇%唐泽天
馬閤囌提%靳宏勇%唐澤天
마합소제%근굉용%당택천
前列腺增生%中医药治疗%前列癃闭通%酸性磷酸酶
前列腺增生%中醫藥治療%前列癃閉通%痠性燐痠酶
전렬선증생%중의약치료%전렬륭폐통%산성린산매
Prostate hyperplasia%Traditional Chinese medicine treatment%Top uroschesis sense%Acid phosphatase
目的 观察前列癃闭通胶囊对大鼠前列腺增生的影响,为临床中药治疗前列腺增生提供依据.方法 取SD雄性2个月龄大鼠30只,完全随机分成正常对照组、模型组和前列癃闭通治疗组各10只.应用去势大鼠皮下注射丙酸睾丸酮诱导前列腺增生,观察正常对照组、模型组、前列癃闭通组大鼠前列腺的湿重、前列腺指数、酸性磷酸酶的变化.结果 前列癃闭通组大鼠前列腺的湿重(375 ±58)mg、前列腺指数(1.68±0.22)和酸性磷酸酶(5.6±1.2)均明显低于模型组[湿重:(419±53) mg;前列腺指数:2.11 ±0.19;酸性磷酸酶:(8.2±1.3)U/L],差异有统计学意义(P＜0.01),并接近正常组的数值[湿重:(321±20) mg;前列腺指数:1.08±0.12;酸性磷酸酶:(5.1±0.1)U/L].结论 前列癃闭通胶囊可明显抑制大鼠前列腺增生,抑制大鼠血清酸性磷酸酶水平升高,临床上可以利用中药前列癃闭通胶囊治疗良性前列腺增生症.
目的 觀察前列癃閉通膠囊對大鼠前列腺增生的影響,為臨床中藥治療前列腺增生提供依據.方法 取SD雄性2箇月齡大鼠30隻,完全隨機分成正常對照組、模型組和前列癃閉通治療組各10隻.應用去勢大鼠皮下註射丙痠睪汍酮誘導前列腺增生,觀察正常對照組、模型組、前列癃閉通組大鼠前列腺的濕重、前列腺指數、痠性燐痠酶的變化.結果 前列癃閉通組大鼠前列腺的濕重(375 ±58)mg、前列腺指數(1.68±0.22)和痠性燐痠酶(5.6±1.2)均明顯低于模型組[濕重:(419±53) mg;前列腺指數:2.11 ±0.19;痠性燐痠酶:(8.2±1.3)U/L],差異有統計學意義(P＜0.01),併接近正常組的數值[濕重:(321±20) mg;前列腺指數:1.08±0.12;痠性燐痠酶:(5.1±0.1)U/L].結論 前列癃閉通膠囊可明顯抑製大鼠前列腺增生,抑製大鼠血清痠性燐痠酶水平升高,臨床上可以利用中藥前列癃閉通膠囊治療良性前列腺增生癥.
목적 관찰전렬륭폐통효낭대대서전렬선증생적영향,위림상중약치료전렬선증생제공의거.방법 취SD웅성2개월령대서30지,완전수궤분성정상대조조、모형조화전렬륭폐통치료조각10지.응용거세대서피하주사병산고환동유도전렬선증생,관찰정상대조조、모형조、전렬륭폐통조대서전렬선적습중、전렬선지수、산성린산매적변화.결과 전렬륭폐통조대서전렬선적습중(375 ±58)mg、전렬선지수(1.68±0.22)화산성린산매(5.6±1.2)균명현저우모형조[습중:(419±53) mg;전렬선지수:2.11 ±0.19;산성린산매:(8.2±1.3)U/L],차이유통계학의의(P＜0.01),병접근정상조적수치[습중:(321±20) mg;전렬선지수:1.08±0.12;산성린산매:(5.1±0.1)U/L].결론 전렬륭폐통효낭가명현억제대서전렬선증생,억제대서혈청산성린산매수평승고,림상상가이이용중약전렬륭폐통효낭치료량성전렬선증생증.
Objective To observe influence of Top uroschesis tong capsule on prostatic hyperplasia of rats.Methods A total of 30 of 2 month olds male rats were assigned randomly into normal control group (n =10),model group(n =10) and topuroschesis treatment group(n =10).The prostate hyperplasia of castrated rats was induced by subcutaneous testosterone propionate ; the changes of wet weight,prostatic index,acid phosphatase (ACP) of rat prostate in each group were analyzed.Results Wet weight was (375 ± 58) mg; prostate index was 1.68 ± 0.22 and acid phosphatase was 5.6 ± 1.2 in topuroschesis treatment group; wet weight was (419 ± 53) mg; prostate index was 2.11 ± 0.19 ; acid phosphatase was 8.2 ± 1.3 ; there was a significant difference in both groups (P ＜0 01),and there was no difference between in the topuroschesis treatment group and in the normal control group [wet weight:(321 ± 20) mg; prostate index:1.08 ± 0.12; acid phosphatase:5.1± 0.1].Conclusions Forefront uroschesis tong capsule can inhibit prostate hyperplasia and the increased levels of serum acid phosphatase in rats.
