中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
8期
1141-1146
,共6页
崔红丽%李晓峰%燕毅男%陈伟荣%李新毅
崔紅麗%李曉峰%燕毅男%陳偉榮%李新毅
최홍려%리효봉%연의남%진위영%리신의
载脂蛋白E%基因多态性%阿尔茨海默病%Meta分析
載脂蛋白E%基因多態性%阿爾茨海默病%Meta分析
재지단백E%기인다태성%아이자해묵병%Meta분석
Apolipoprotein E%Polymorphism%Alzheimer's disease%Meta-analysis
目的 探讨中国人群载脂蛋白E基因多态性与阿尔茨海默病(AD)的相关性.方法 检索相关文献,按纳入排除标准筛选后提取相关数据.应用RevMan 5.0软件进行异质性检验和数据合并,并进行敏感性分析.应用Stata 12.0软件评估发表偏倚.结果 共纳入11篇合格文献(13项研究),累计2 577例,其中AD组l 209例,对照组1 368例.Meta分析结果显示,ApoE ε4等位基因及e3/4、ε4/4基因型携带者AD易感性明显升高,差异有统计学意义[ε4 vs ε3:比值比(OR)=2.88,95％置信区间(CI)为2.41 ～3.44;ε3/4 vs e3/3:OR =2.62,95％ CI为2.11 ～3.25; ε4/4 vs ε3/3:OR =7.98,95％ CI为4.21～15.13];ApoE e2等位基因及ε2/3基因型携带者AD易感性降低,差异有统计学意义(e2 vs ε3:OR =0.77,95％ CI为0.62 ～ 0.96;e2/3 vs ε3/3:OR=0.76,95％ CI为0.58～0.98).结论 中国人群ApoE基因多态性与AD密切相关.
目的 探討中國人群載脂蛋白E基因多態性與阿爾茨海默病(AD)的相關性.方法 檢索相關文獻,按納入排除標準篩選後提取相關數據.應用RevMan 5.0軟件進行異質性檢驗和數據閤併,併進行敏感性分析.應用Stata 12.0軟件評估髮錶偏倚.結果 共納入11篇閤格文獻(13項研究),纍計2 577例,其中AD組l 209例,對照組1 368例.Meta分析結果顯示,ApoE ε4等位基因及e3/4、ε4/4基因型攜帶者AD易感性明顯升高,差異有統計學意義[ε4 vs ε3:比值比(OR)=2.88,95％置信區間(CI)為2.41 ～3.44;ε3/4 vs e3/3:OR =2.62,95％ CI為2.11 ～3.25; ε4/4 vs ε3/3:OR =7.98,95％ CI為4.21～15.13];ApoE e2等位基因及ε2/3基因型攜帶者AD易感性降低,差異有統計學意義(e2 vs ε3:OR =0.77,95％ CI為0.62 ～ 0.96;e2/3 vs ε3/3:OR=0.76,95％ CI為0.58～0.98).結論 中國人群ApoE基因多態性與AD密切相關.
목적 탐토중국인군재지단백E기인다태성여아이자해묵병(AD)적상관성.방법 검색상관문헌,안납입배제표준사선후제취상관수거.응용RevMan 5.0연건진행이질성검험화수거합병,병진행민감성분석.응용Stata 12.0연건평고발표편의.결과 공납입11편합격문헌(13항연구),루계2 577례,기중AD조l 209례,대조조1 368례.Meta분석결과현시,ApoE ε4등위기인급e3/4、ε4/4기인형휴대자AD역감성명현승고,차이유통계학의의[ε4 vs ε3:비치비(OR)=2.88,95％치신구간(CI)위2.41 ～3.44;ε3/4 vs e3/3:OR =2.62,95％ CI위2.11 ～3.25; ε4/4 vs ε3/3:OR =7.98,95％ CI위4.21～15.13];ApoE e2등위기인급ε2/3기인형휴대자AD역감성강저,차이유통계학의의(e2 vs ε3:OR =0.77,95％ CI위0.62 ～ 0.96;e2/3 vs ε3/3:OR=0.76,95％ CI위0.58～0.98).결론 중국인군ApoE기인다태성여AD밀절상관.
Objective To evaluate the relation between gene polymorphisms of ApoE and Alzheimer's disease in Chinese population.Methods The literatures were fully searched through computed databases,such PUBMED,CNKI,CBM,VIP and Wanfang.The relevant data were extracted according to the inclusion and exclusion criteria.RevMan 5.0 was applied to do heterogeneity test,data consolidation and sensitivity analysis.The publication bias was evaluated by Stata 12.0.Results The 11 eligible articles (13 studies) were included,a total of 2 577 cases,including 1 209 cases in the Alzheimer's disease group,1 368 cases in the control group.The meta-analysis showed that individuals with ApoE 4 allele and ε3/4,ε4/4 genotype were significantly associated with the risk of Alzheimer's disease[ε4 vs ε3:odds ratio(OR) =2.88,95％ confidence interval(CI) (2.41,3.44) ; ε3/4 vs ε3/3:OR =2.62,95％ CI(2.11,3.25) ; ε4/4 vs ε3/3:OR =7.98,95 ％ CI(4.21,15.13)].Individuals with ApoE ε2 allele and ε2/3 genotype were significantly associated with the risk of Alzheimer's disease[ε2 vs ε3:OR =0.77,95％CI(0.62,0.96); ε2/3 vs ε3/3:0R=0.76,95％CI(0.58,0.98)].Conclusion ApoE gene polymorphisms are closely associated with the occurrence of Alzheimer's disease in Chinese population.
