中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
8期
1164-1166
,共3页
肝炎,乙型%家族聚集性%流行病学调查%抗病毒治疗%转归
肝炎,乙型%傢族聚集性%流行病學調查%抗病毒治療%轉歸
간염,을형%가족취집성%류행병학조사%항병독치료%전귀
Hepatitis B%Familial aggregation%Epidemiological investigations%Antiviral treatment%Outcome
目的 探讨家族性乙型肝炎的感染途径及其对临床转归的影响.方法 采用流行病学研究方法,对279例家族性乙型肝炎感染者当面或电话询问,了解其乙型肝炎病毒(HBV)的感染途径、治疗及病情进展等情况,并对相关指标进行统计分析.结果 279例HBV感染者中母亲单方为HBV感染者占46.6％ (130/279),母亲以自然分娩为主,97.2％(70/72)没有采取阻断措施.随着父母年龄的增长,其子女HBV的感染率增加,尤其是40岁以上的父母,感染率为92.9％ (92/99) (x2=39.545,P＜0.01).抗病毒的进展率较未抗病毒的患者的疾病进展率明显降低,差异有统计学意义[25.0％(24/96)比38.8％ (71/183),x2=5.338,P＜0.05].年龄在40岁以上的患者容易发生疾病进展.终末期肝病——乙型肝炎肝硬化、肝癌患者中,随着疾病进展,HBVe抗原(HBeAg)阳性比例减少[肝硬化38.2％(34/89)、肝癌18.2％(8/44)] (x2=11.353,P＜0.05),HBV-DNA阳性比例增加[肝硬化52.8％ (47/89)、肝癌56.8％ (25/44)](x2=5.300,P＜0.05).结论 家族性乙型肝炎的感染途径仍以母婴为主,没有采取阻断措施可能是其高感染率的主要原因;抗病毒治疗可以延缓疾病的进展、有效改善患者的预后;此外还应关注以HBeAg阴性、HBV-DNA阴性感染模式的乙型肝炎终末期肝病研究.
目的 探討傢族性乙型肝炎的感染途徑及其對臨床轉歸的影響.方法 採用流行病學研究方法,對279例傢族性乙型肝炎感染者噹麵或電話詢問,瞭解其乙型肝炎病毒(HBV)的感染途徑、治療及病情進展等情況,併對相關指標進行統計分析.結果 279例HBV感染者中母親單方為HBV感染者佔46.6％ (130/279),母親以自然分娩為主,97.2％(70/72)沒有採取阻斷措施.隨著父母年齡的增長,其子女HBV的感染率增加,尤其是40歲以上的父母,感染率為92.9％ (92/99) (x2=39.545,P＜0.01).抗病毒的進展率較未抗病毒的患者的疾病進展率明顯降低,差異有統計學意義[25.0％(24/96)比38.8％ (71/183),x2=5.338,P＜0.05].年齡在40歲以上的患者容易髮生疾病進展.終末期肝病——乙型肝炎肝硬化、肝癌患者中,隨著疾病進展,HBVe抗原(HBeAg)暘性比例減少[肝硬化38.2％(34/89)、肝癌18.2％(8/44)] (x2=11.353,P＜0.05),HBV-DNA暘性比例增加[肝硬化52.8％ (47/89)、肝癌56.8％ (25/44)](x2=5.300,P＜0.05).結論 傢族性乙型肝炎的感染途徑仍以母嬰為主,沒有採取阻斷措施可能是其高感染率的主要原因;抗病毒治療可以延緩疾病的進展、有效改善患者的預後;此外還應關註以HBeAg陰性、HBV-DNA陰性感染模式的乙型肝炎終末期肝病研究.
목적 탐토가족성을형간염적감염도경급기대림상전귀적영향.방법 채용류행병학연구방법,대279례가족성을형간염감염자당면혹전화순문,료해기을형간염병독(HBV)적감염도경、치료급병정진전등정황,병대상관지표진행통계분석.결과 279례HBV감염자중모친단방위HBV감염자점46.6％ (130/279),모친이자연분면위주,97.2％(70/72)몰유채취조단조시.수착부모년령적증장,기자녀HBV적감염솔증가,우기시40세이상적부모,감염솔위92.9％ (92/99) (x2=39.545,P＜0.01).항병독적진전솔교미항병독적환자적질병진전솔명현강저,차이유통계학의의[25.0％(24/96)비38.8％ (71/183),x2=5.338,P＜0.05].년령재40세이상적환자용역발생질병진전.종말기간병——을형간염간경화、간암환자중,수착질병진전,HBVe항원(HBeAg)양성비례감소[간경화38.2％(34/89)、간암18.2％(8/44)] (x2=11.353,P＜0.05),HBV-DNA양성비례증가[간경화52.8％ (47/89)、간암56.8％ (25/44)](x2=5.300,P＜0.05).결론 가족성을형간염적감염도경잉이모영위주,몰유채취조단조시가능시기고감염솔적주요원인;항병독치료가이연완질병적진전、유효개선환자적예후;차외환응관주이HBeAg음성、HBV-DNA음성감염모식적을형간염종말기간병연구.
Objective To investigate the infection route of familial hepatitis B and the impact factors on clinical outcomes.Methods Totally 279 patients with familial hepatitis B and their relatives was retrospectively observed.Results The percentage of hepatitis B virus-infected mothers was 46.6％ (130/279) ; most of the cases were natural childbirth and 97.2％ (70/72)of parents did not take blocking methods.The children hepatitis B virus infection rate was increased,especially with the parents who were over 40 years old; the infection rate was 92.9％ (92/99) (x2 =39.545,P ＜0.01).The age of 40 years or older had a higher prevalence of disease.In the patients of end-stage liver disease such as cirrhosis and liver cancer,the proportion of HBeAg positive was reduced [cirrhosis was 38.2％ (34/89),liver cancer was 18.2％ (8/44),x2 =11.353,P ＜ 0.05] and hepatitis B virus positive rate was increased[cirrhosis was 52.8％ (47/89) ; liver cancer was 56.8％ (25/44)] (x2 =5.300,P ＜0.05).Conclusions Route of infection of familial hepatitis B infection is still mainly mother-to-child transmission and the main reason of infection is no blocking measures.Aggressive antiviral treatment can delay the progression of the disease and improve the prognosis of patients.
