CAJ | 학술논문

目的探讨血清降钙素原监测在重症胰腺炎患者抗生素治疗中的指导意义.方法将2012年10月至2013年9月于广东省惠州市中心人民医院入住重症监护病房的71例重症急性胰腺炎患者按随机数字表法分为血清降钙素原监测指导应用抗生素的试验组或无降钙素原指导预防性抗生素治疗的对照组.对抗生素治疗时间、住院治疗时间、住院费用等进行统计分析.结果试验组抗生素治疗时间为(10.9±2.8)d,住院时间(16.7±4.0)d;对照组抗生素治疗时间为(16.1 ±2.5)d,住院时间(23.8±7.6)d,2组比较差异有统计学意义(P＜0.05),试验组住院费用也明显低于对照组[(153 726±16 578)元比(187 740±15 935)元,P＜0.05].结论血清降钙素原监测对重症胰腺炎患者的抗生素治疗有指导作用,有利于减少抗生素的使用时间、缩短住院时间并降低住院费用.
목적 탐토혈청강개소원감측재중증이선염환자항생소치료중적지도의의.방법 장2012년10월지2013년9월우광동성혜주시중심인민의원입주중증감호병방적71례중증급성이선염환자안수궤수자표법분위혈청강개소원감측지도응용항생소적시험조혹무강개소원지도예방성항생소치료적대조조.대항생소치료시간、주원치료시간、주원비용등진행통계분석.결과 시험조항생소치료시간위(10.9±2.8)d,주원시간(16.7±4.0)d;대조조항생소치료시간위(16.1 ±2.5)d,주원시간(23.8±7.6)d,2조비교차이유통계학의의(P＜0.05),시험조주원비용야명현저우대조조[(153 726±16 578)원비(187 740±15 935)원,P＜0.05].결론 혈청강개소원감측대중증이선염환자적항생소치료유지도작용,유리우감소항생소적사용시간、축단주원시간병강저주원비용.
Objective To investigate the clinical use of procalcitoniu(PCT) for guiding antibiotic therapy in patients with severe acute pancreatitis(SAP).Methods A total of 71 patients with confirmed severe acute panereatitis were enrolled from October 2012 to September 2013 at ICU of Huizhou Maneipal central Hospital.Patients were randomly assigned to either a PCT-guided (study group) or a prophylactic antibiotic therapy (control group).The antibiotic therapy time,hospitalization days and hospitalization cost were analyzed.Results The duration of antibiotic therapy and hospitalization were significantly shorter in the study group than in the control group [duration of antibiotic therapy (10.9 ± 2.8) days vs (16.1 ± 2.5) days,P ＜ 0.05],and [duration of hospitalization,(16.7 ± 4.0) days vs (23.8 ± 7.6 days),P ＜ 0.05].The cost of hospitalization was significantly lower in the study group than in the control group [(153 726 ± 16 578) yuan vs (187 740 ± 15 935) yuan,P ＜0.05].Conclusions Monitoring of PCT is a helpful and safe tool for guiding antibiotic treatment in patients with severe acute pancreatitis.This may contribute to an optimized antibiotic regimen with beneficial effects on microbial resistance and costs in hospital.