中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
11期
1582-1584
,共3页
婴幼儿%反复喘息%25-羟维生素D3%总免疫球蛋白E%嗜酸性粒细胞
嬰幼兒%反複喘息%25-羥維生素D3%總免疫毬蛋白E%嗜痠性粒細胞
영유인%반복천식%25-간유생소D3%총면역구단백E%기산성립세포
Infant%Recurrent wheezing%25 hydroxy vitamin D3%Total IgE%Eosinophilia cell
目的 探讨血清25-羟维生素D3 [25-(OH)D3]及总水平与婴幼儿反复喘息的关系.方法 分别采用酶联免疫吸附测定、免疫比浊法,检测反复喘息的婴幼儿60例(反复喘息婴幼儿组)及正常对照儿童60例(对照组)血清中25-(OH)D3、TIgE含量.采用全自动血细胞分析仪检测2组外周血嗜酸性粒细胞百分比(EOS％),并做比较.结果 反复喘息婴幼儿组血清25-(OH)D3含量明显低于对照组,2组比较差异有统计学意义[(18±6)μg/L比(38 ±8) μg/L,t=15.81,P=0.000];反复喘息婴幼儿组血清TIgE含量、EOS％明显高于对照组,2组比较差异有统计学意义[(122±18) IU/ml比(51±10) IU/ml,t=25.84,P=0.000;(3.02±1.82)％比(0.72±0.27)％,=9.73,P=0.000];反复喘息婴幼儿组血清25-(OH) D3含量与TIgE含量存在负相关(r=-0.783,P=0.000),对照组血清25-(OH)D3含量与TIgE含量无相关性(r=-0.013,P=0.924).2组血清25-(OH) D3含量与EOS％无相关性(r=-0.084,P=0.523;r=-0.137,P =0.298).结论 血清25-(OH)D3的低下可能为婴幼儿反复喘息的高危因素;反复喘息的婴幼儿组血清25-(OH) D3与TIgE有明显负相关性,表明婴幼儿反复喘息与变态反应密切相关.补充维生素D3可能为临床预防婴幼儿反复喘息提供新思路.
目的 探討血清25-羥維生素D3 [25-(OH)D3]及總水平與嬰幼兒反複喘息的關繫.方法 分彆採用酶聯免疫吸附測定、免疫比濁法,檢測反複喘息的嬰幼兒60例(反複喘息嬰幼兒組)及正常對照兒童60例(對照組)血清中25-(OH)D3、TIgE含量.採用全自動血細胞分析儀檢測2組外週血嗜痠性粒細胞百分比(EOS％),併做比較.結果 反複喘息嬰幼兒組血清25-(OH)D3含量明顯低于對照組,2組比較差異有統計學意義[(18±6)μg/L比(38 ±8) μg/L,t=15.81,P=0.000];反複喘息嬰幼兒組血清TIgE含量、EOS％明顯高于對照組,2組比較差異有統計學意義[(122±18) IU/ml比(51±10) IU/ml,t=25.84,P=0.000;(3.02±1.82)％比(0.72±0.27)％,=9.73,P=0.000];反複喘息嬰幼兒組血清25-(OH) D3含量與TIgE含量存在負相關(r=-0.783,P=0.000),對照組血清25-(OH)D3含量與TIgE含量無相關性(r=-0.013,P=0.924).2組血清25-(OH) D3含量與EOS％無相關性(r=-0.084,P=0.523;r=-0.137,P =0.298).結論 血清25-(OH)D3的低下可能為嬰幼兒反複喘息的高危因素;反複喘息的嬰幼兒組血清25-(OH) D3與TIgE有明顯負相關性,錶明嬰幼兒反複喘息與變態反應密切相關.補充維生素D3可能為臨床預防嬰幼兒反複喘息提供新思路.
목적 탐토혈청25-간유생소D3 [25-(OH)D3]급총수평여영유인반복천식적관계.방법 분별채용매련면역흡부측정、면역비탁법,검측반복천식적영유인60례(반복천식영유인조)급정상대조인동60례(대조조)혈청중25-(OH)D3、TIgE함량.채용전자동혈세포분석의검측2조외주혈기산성립세포백분비(EOS％),병주비교.결과 반복천식영유인조혈청25-(OH)D3함량명현저우대조조,2조비교차이유통계학의의[(18±6)μg/L비(38 ±8) μg/L,t=15.81,P=0.000];반복천식영유인조혈청TIgE함량、EOS％명현고우대조조,2조비교차이유통계학의의[(122±18) IU/ml비(51±10) IU/ml,t=25.84,P=0.000;(3.02±1.82)％비(0.72±0.27)％,=9.73,P=0.000];반복천식영유인조혈청25-(OH) D3함량여TIgE함량존재부상관(r=-0.783,P=0.000),대조조혈청25-(OH)D3함량여TIgE함량무상관성(r=-0.013,P=0.924).2조혈청25-(OH) D3함량여EOS％무상관성(r=-0.084,P=0.523;r=-0.137,P =0.298).결론 혈청25-(OH)D3적저하가능위영유인반복천식적고위인소;반복천식적영유인조혈청25-(OH) D3여TIgE유명현부상관성,표명영유인반복천식여변태반응밀절상관.보충유생소D3가능위림상예방영유인반복천식제공신사로.
Objective To study the changes and clinical significance of serum levels of 25 hydroxy vitamin D3 [25-(OH)D3] and total IgE and peripheral blood eosinophilia cell percentage (EOS％)in infants with recurrent wheezing.Methods Sixty infants with recurrent wheezing and sixty healthy children were enrolled.Enzyme linked immunosorbentassay was used to detect the levels of serum 25-(OH)D3 and immunoturbidimetry was used to detect the levels of total IgE.Automatic blood cell analyzer was used to detect EOS％ of the two groups.Results Serum 25-(OH) D3 levels decreased significantly in infants with recurrent wheezing group,compared with the normal group [(18 ±6)μg/L vs (38 ±8)μg/L] (t =15.81,P =0.000).In contrast,serum total IgE levels increased significantly in infants with recurrent wheezing group,compared with the normal group [(122 ± 18)IU/ml vs (51 ± 10)IU/ml,(3.02 ± 1.82)％ vs (0.72 ±0.27)％] (t =25.84,P =0.000).EOS％ increased significantly in the infants with recurrent wheezing group compared with the normal group(t =9.73,P =0.000).Serum 25-(OH)D3 levels were negatively correlated with serum total IgE level in the infants with recurrent wheezing group(r =-0.768,P =0.000).There was no correlation between serum 25-(OH) D3 levels and serum total IgE levels in the normal group(r =-0.013,P =0.924).Serum 25-(OH)D3 levels had no correlation with EOS％ in both groups (r =-0.084,P =0.523;r =-0.137,P=0.298).Conclusions Low serum25-(OH)D3 may be the risk factor of recurrent wheezing in infants.Serum 25-(OH)D3 levels are negatively correlated with serum total IgE levels in the infants with recurrent wheezing group; recurrent wheezing in the infants is closely related to allergic reaction.The supplement of vitamin D3 may provide new ideas for clinical prevention of infant recurrent wheezing.
