中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
11期
1613-1615
,共3页
张军伟%王宝华%杨颖%白静%程爱斌
張軍偉%王寶華%楊穎%白靜%程愛斌
장군위%왕보화%양영%백정%정애빈
高敏C反应蛋白%动脉粥样硬化%彩色多普勒超声
高敏C反應蛋白%動脈粥樣硬化%綵色多普勒超聲
고민C반응단백%동맥죽양경화%채색다보륵초성
High sensitivity C-reactive protein%Carotid atherosclerosis%Color Doppler ultrasound
目的 探讨高敏C反应蛋白(hs-CRP)和颈动脉粥样硬化的关系.方法 选取唐山市某社区年龄在25～90岁的161例志愿者为研究对象,根据其血浆hs-CRP水平分为高hs-CRP组(hs-CRP＞3mg/L,80例)和hs-CRP正常组(hs-CRP≤3 mg/L,81例),经颈部血管超声检查,观察2组受检者颈动脉内膜-中层厚度、颈动脉斑块性质及管腔狭窄程度.结果 高hs-CRP组受试者的平均年龄大于hs-CRP正常组,差异有统计学意义[(60±13)岁比(48±7)岁,t=-7.81,P＜0.01].高hs-CRP组颈总动脉和颈内动脉内膜中层厚度均大于hs-CRP正常组,差异均有统计学意义[分别为(0.86 ±0.16)mm比(0.76 ±0.12)mm,t＝-4.390,P＜0.01;(0.74±0.11)mm比(0.68 ±0.06) mm,t=-3.560,P＜0.01].高hs-CRP组斑块检出率为93.8％ (75/80),高于hs-CRP正常组的34.6％(28/81)(x2 =35.96,P＜0.01).颈总动脉和颈内动脉狭窄的检出率在高hs-CRP组为45.0％(36/80)和17.5％(14/81),高于hs-CRP正常组[分别为18.6％(15/81)、3.7％(3/81)],差异有统计学意义(x2=12.70,P＜0.01;x2=8.11,P＜0.01).结论 高水平的hs-CRP促进正常人群的动脉粥样硬化.
目的 探討高敏C反應蛋白(hs-CRP)和頸動脈粥樣硬化的關繫.方法 選取唐山市某社區年齡在25～90歲的161例誌願者為研究對象,根據其血漿hs-CRP水平分為高hs-CRP組(hs-CRP＞3mg/L,80例)和hs-CRP正常組(hs-CRP≤3 mg/L,81例),經頸部血管超聲檢查,觀察2組受檢者頸動脈內膜-中層厚度、頸動脈斑塊性質及管腔狹窄程度.結果 高hs-CRP組受試者的平均年齡大于hs-CRP正常組,差異有統計學意義[(60±13)歲比(48±7)歲,t=-7.81,P＜0.01].高hs-CRP組頸總動脈和頸內動脈內膜中層厚度均大于hs-CRP正常組,差異均有統計學意義[分彆為(0.86 ±0.16)mm比(0.76 ±0.12)mm,t＝-4.390,P＜0.01;(0.74±0.11)mm比(0.68 ±0.06) mm,t=-3.560,P＜0.01].高hs-CRP組斑塊檢齣率為93.8％ (75/80),高于hs-CRP正常組的34.6％(28/81)(x2 =35.96,P＜0.01).頸總動脈和頸內動脈狹窄的檢齣率在高hs-CRP組為45.0％(36/80)和17.5％(14/81),高于hs-CRP正常組[分彆為18.6％(15/81)、3.7％(3/81)],差異有統計學意義(x2=12.70,P＜0.01;x2=8.11,P＜0.01).結論 高水平的hs-CRP促進正常人群的動脈粥樣硬化.
목적 탐토고민C반응단백(hs-CRP)화경동맥죽양경화적관계.방법 선취당산시모사구년령재25～90세적161례지원자위연구대상,근거기혈장hs-CRP수평분위고hs-CRP조(hs-CRP＞3mg/L,80례)화hs-CRP정상조(hs-CRP≤3 mg/L,81례),경경부혈관초성검사,관찰2조수검자경동맥내막-중층후도、경동맥반괴성질급관강협착정도.결과 고hs-CRP조수시자적평균년령대우hs-CRP정상조,차이유통계학의의[(60±13)세비(48±7)세,t=-7.81,P＜0.01].고hs-CRP조경총동맥화경내동맥내막중층후도균대우hs-CRP정상조,차이균유통계학의의[분별위(0.86 ±0.16)mm비(0.76 ±0.12)mm,t＝-4.390,P＜0.01;(0.74±0.11)mm비(0.68 ±0.06) mm,t=-3.560,P＜0.01].고hs-CRP조반괴검출솔위93.8％ (75/80),고우hs-CRP정상조적34.6％(28/81)(x2 =35.96,P＜0.01).경총동맥화경내동맥협착적검출솔재고hs-CRP조위45.0％(36/80)화17.5％(14/81),고우hs-CRP정상조[분별위18.6％(15/81)、3.7％(3/81)],차이유통계학의의(x2=12.70,P＜0.01;x2=8.11,P＜0.01).결론 고수평적hs-CRP촉진정상인군적동맥죽양경화.
Objective To study the correlation between serum high sensitivity C-reactive protein (hs-CRP)and carotid atherosclerosis.Methods Totally 161 volunteers from 25 to 90 years old were collected.The serum level of hs-CRP was measured and separated into high hs-CRP group and hs-CRP normal group.The carotid atherosclerosis was detected by the color Doppler ultrasound to check intima-media thickness (IMT),followed by measurements for the state of carotid artery atherosclerosis and the rate of vessel stenosis.Results The average age in high hs-CRP group was higher than that of the hs-CRP normal group,which showed a significant difference [(60 ± 13) years vs.(48 ± 7) years,t =-7.81,P ＜ 0.01].The common carotid artery IMT,internal carotid artery IMT and carotid artery plaque for the high hs-CRP group were (0.86 ± 0.16) mm,(0.74 ± 0.11) mm,and 93.8％ (75/80) respectively,while they were(0.76 ±0.12) mm,(0.68 ± 0.06) mm and 34.6％ (28/80) in hs-CRP normal group,which demonstrates significant differences between the two groups(t =-4.39,P ＜0.01 ;t =-3.56,P ＜ 0.01 ;x2 =35.96,P ＜ 0.01).Compared to the hs-CRP normal group [18.6％ (15/81),3.7％ (3/81)],the detection rate of stenosis of the common carotid artery and internal carotid artery in high hs-CRP group was 45.0％ and 17.5％,which showed a significant difference (x2 =12.70,P ＜0.01 ;x2 =8.11,P ＜0.01).Conclusion High level of hs-CRP can enhance carotid atherosclerosis.
