中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2011年
11期
797-799
,共3页
王国江%董达科%张海清%陈向明%顾军
王國江%董達科%張海清%陳嚮明%顧軍
왕국강%동체과%장해청%진향명%고군
激素依赖性皮炎%强脉冲光%猪%雏型%光疗法
激素依賴性皮炎%彊脈遲光%豬%雛型%光療法
격소의뢰성피염%강맥충광%저%추형%광요법
Corticosteroid dependent dermatitis%Intense pulsed light%Swine%miniature%Phototherapy
目的 探讨强脉冲光对巴马香猪糖皮质激素诱导的皮炎模型皮肤组织病理的影响.方法 选用2月龄雌性巴马香猪5只,将颈部两侧白色皮毛区作为实验靶皮肤区域,右侧外用0.05％卤米松乳膏每日涂药2次,连续用药60d,形成糖皮质激素诱导的皮炎模型.随机选3只给予强脉冲光治疗糖皮质激素诱导的皮炎区域,能量为25 J/cm2,每3周1次,共3次；另2只不给予治疗作为自然恢复组观察9周.局部皮肤组织做HE染色,观察各组皮肤病理变化.结果 巴马香猪糖皮质激素诱导的皮炎模型组经强脉冲光治疗后,表皮角质形成细胞层数为( 6.27±1.26)层,较自然恢复组(2.98±0.92层)明显增加(t=3.27,P＜0.01)；真皮胶原纤维厚度为( 1.88±0.19) mm,也较自然恢复组(0.84±0.15 mm)明显增加(t=4.25,P＜0.01),真皮内扩张的毛细血管消退.结论 强脉冲光能有效增加皮肤厚度,消除皮肤红斑,增加皮肤弹性.
目的 探討彊脈遲光對巴馬香豬糖皮質激素誘導的皮炎模型皮膚組織病理的影響.方法 選用2月齡雌性巴馬香豬5隻,將頸部兩側白色皮毛區作為實驗靶皮膚區域,右側外用0.05％滷米鬆乳膏每日塗藥2次,連續用藥60d,形成糖皮質激素誘導的皮炎模型.隨機選3隻給予彊脈遲光治療糖皮質激素誘導的皮炎區域,能量為25 J/cm2,每3週1次,共3次；另2隻不給予治療作為自然恢複組觀察9週.跼部皮膚組織做HE染色,觀察各組皮膚病理變化.結果 巴馬香豬糖皮質激素誘導的皮炎模型組經彊脈遲光治療後,錶皮角質形成細胞層數為( 6.27±1.26)層,較自然恢複組(2.98±0.92層)明顯增加(t=3.27,P＜0.01)；真皮膠原纖維厚度為( 1.88±0.19) mm,也較自然恢複組(0.84±0.15 mm)明顯增加(t=4.25,P＜0.01),真皮內擴張的毛細血管消退.結論 彊脈遲光能有效增加皮膚厚度,消除皮膚紅斑,增加皮膚彈性.
목적 탐토강맥충광대파마향저당피질격소유도적피염모형피부조직병리적영향.방법 선용2월령자성파마향저5지,장경부량측백색피모구작위실험파피부구역,우측외용0.05％서미송유고매일도약2차,련속용약60d,형성당피질격소유도적피염모형.수궤선3지급여강맥충광치료당피질격소유도적피염구역,능량위25 J/cm2,매3주1차,공3차；령2지불급여치료작위자연회복조관찰9주.국부피부조직주HE염색,관찰각조피부병리변화.결과 파마향저당피질격소유도적피염모형조경강맥충광치료후,표피각질형성세포층수위( 6.27±1.26)층,교자연회복조(2.98±0.92층)명현증가(t=3.27,P＜0.01)；진피효원섬유후도위( 1.88±0.19) mm,야교자연회복조(0.84±0.15 mm)명현증가(t=4.25,P＜0.01),진피내확장적모세혈관소퇴.결론 강맥충광능유효증가피부후도,소제피부홍반,증가피부탄성.
Objective To assess the impact of intense pulsed light (IPL) on the dermatopathological manifestation in a Bama miniature pig model of steroid-induced dermatitis.Methods Five female Bama miniature pigs aged two months were selected.The white skin areas with white hair at both sides of the neck served as the target area.Halometasone (0.05％) cream was applied to the right target area twice daily for 60 days to establish a model of steroid-induced dermatitis.Then,3 pigs were randomly selected and irradiated with IPL of 25 J/cm2 at the model area with an interval of 3 weeks for 9 weeks,the remaining 2 pigs receiving no treatment served as the natural recovery group.Finally,skin tissues were obtained from the left and right target areas and subjected to haematoxylin and eosin staining for the observation of histopathological changes.Results A significant increase was observed in the layer number of keratinocytes and thickness of dermal collagen fiber in the IPL-treated pigs compared with the pigs in natural recovery group (6.27 ± 1.26 vs.2.98 ±0.92,t =3.27,P＜ 0.01; 1.88 ± 0.19 mm vs.0.84 ± 0.15 mm,t =4.25,P＜ 0.01).Moreover,IPL irradiation resulted in the regression of telangiectasis in the dermis.Conclusion IPL may increase skin thickness,relieve flushing and improve skin elasticity efficiently.
